Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026756305> ?p ?o ?g. }
- W2026756305 endingPage "8" @default.
- W2026756305 startingPage "1" @default.
- W2026756305 abstract "Maintenance of the mucosal barrier is a critical function of intestinal epithelial tight junction. Berberine is one of the main constituents of Coptidis rhizoma, which has been used for patients with gastrointestinal disorders for a long time. This study aimed to determine whether berberine could alleviate pro-inflammatory cytokine-induced intestinal epithelial tight junction damage. Caco-2 monolayers were treated with tumor necrosis factor-α and interferon-γ to induce barrier dysfunction. The protective effect of berberine on tight junctions was analyzed by measuring the trans-epithelial electrical resistance (TEER). Transmission electron microscopy was used to observe the morphology of tight junction, and subcellular localization of tight junction proteins was investigated by immunofluorescence microscopy and Western blot. Berberine significantly prevented pro-inflammatory cytokines induced decrease in TEER. The distortion of tight junction morphology and redistribution of tight junction protein occludin was also prevented by berberine treatment. Western blot analysis demonstrated that berberine inhibit the dislocation of occludin from raft fractions to non-raft fractions in membrane microdomains of tight junctions. We concluded that berberine can ameliorate pro-inflammatory cytokines induced intestinal epithelia tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states." @default.
- W2026756305 created "2016-06-24" @default.
- W2026756305 creator A5013860112 @default.
- W2026756305 creator A5031810848 @default.
- W2026756305 creator A5040135272 @default.
- W2026756305 creator A5058989824 @default.
- W2026756305 creator A5072495806 @default.
- W2026756305 creator A5079424822 @default.
- W2026756305 creator A5086242915 @default.
- W2026756305 date "2010-04-01" @default.
- W2026756305 modified "2023-09-30" @default.
- W2026756305 title "Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells" @default.
- W2026756305 cites W1897551156 @default.
- W2026756305 cites W1964348907 @default.
- W2026756305 cites W1967167260 @default.
- W2026756305 cites W1968647864 @default.
- W2026756305 cites W1972899659 @default.
- W2026756305 cites W1973195425 @default.
- W2026756305 cites W1976252951 @default.
- W2026756305 cites W1990156172 @default.
- W2026756305 cites W1990821907 @default.
- W2026756305 cites W1994153742 @default.
- W2026756305 cites W1997999969 @default.
- W2026756305 cites W2002556891 @default.
- W2026756305 cites W2006194008 @default.
- W2026756305 cites W2009446106 @default.
- W2026756305 cites W2010024704 @default.
- W2026756305 cites W2025444461 @default.
- W2026756305 cites W2041454039 @default.
- W2026756305 cites W2043154317 @default.
- W2026756305 cites W2050613270 @default.
- W2026756305 cites W2055222262 @default.
- W2026756305 cites W2076588832 @default.
- W2026756305 cites W2079224783 @default.
- W2026756305 cites W2090688567 @default.
- W2026756305 cites W2096961219 @default.
- W2026756305 cites W2097929425 @default.
- W2026756305 cites W2104518242 @default.
- W2026756305 cites W2114315236 @default.
- W2026756305 cites W2122039020 @default.
- W2026756305 cites W2127794868 @default.
- W2026756305 cites W2129582474 @default.
- W2026756305 cites W2141071568 @default.
- W2026756305 cites W2155125073 @default.
- W2026756305 cites W2160881772 @default.
- W2026756305 cites W2161138634 @default.
- W2026756305 cites W2161789287 @default.
- W2026756305 cites W2177396386 @default.
- W2026756305 cites W4292198229 @default.
- W2026756305 cites W4313348018 @default.
- W2026756305 doi "https://doi.org/10.1016/j.ejps.2010.02.001" @default.
- W2026756305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20149867" @default.
- W2026756305 hasPublicationYear "2010" @default.
- W2026756305 type Work @default.
- W2026756305 sameAs 2026756305 @default.
- W2026756305 citedByCount "72" @default.
- W2026756305 countsByYear W20267563052012 @default.
- W2026756305 countsByYear W20267563052013 @default.
- W2026756305 countsByYear W20267563052014 @default.
- W2026756305 countsByYear W20267563052015 @default.
- W2026756305 countsByYear W20267563052016 @default.
- W2026756305 countsByYear W20267563052017 @default.
- W2026756305 countsByYear W20267563052018 @default.
- W2026756305 countsByYear W20267563052019 @default.
- W2026756305 countsByYear W20267563052020 @default.
- W2026756305 countsByYear W20267563052021 @default.
- W2026756305 countsByYear W20267563052022 @default.
- W2026756305 countsByYear W20267563052023 @default.
- W2026756305 crossrefType "journal-article" @default.
- W2026756305 hasAuthorship W2026756305A5013860112 @default.
- W2026756305 hasAuthorship W2026756305A5031810848 @default.
- W2026756305 hasAuthorship W2026756305A5040135272 @default.
- W2026756305 hasAuthorship W2026756305A5058989824 @default.
- W2026756305 hasAuthorship W2026756305A5072495806 @default.
- W2026756305 hasAuthorship W2026756305A5079424822 @default.
- W2026756305 hasAuthorship W2026756305A5086242915 @default.
- W2026756305 hasConcept C104317684 @default.
- W2026756305 hasConcept C177779419 @default.
- W2026756305 hasConcept C185592680 @default.
- W2026756305 hasConcept C203014093 @default.
- W2026756305 hasConcept C2775962179 @default.
- W2026756305 hasConcept C2776415932 @default.
- W2026756305 hasConcept C2778690821 @default.
- W2026756305 hasConcept C2780116568 @default.
- W2026756305 hasConcept C51872919 @default.
- W2026756305 hasConcept C51911345 @default.
- W2026756305 hasConcept C55493867 @default.
- W2026756305 hasConcept C86803240 @default.
- W2026756305 hasConcept C95444343 @default.
- W2026756305 hasConceptScore W2026756305C104317684 @default.
- W2026756305 hasConceptScore W2026756305C177779419 @default.
- W2026756305 hasConceptScore W2026756305C185592680 @default.
- W2026756305 hasConceptScore W2026756305C203014093 @default.
- W2026756305 hasConceptScore W2026756305C2775962179 @default.
- W2026756305 hasConceptScore W2026756305C2776415932 @default.
- W2026756305 hasConceptScore W2026756305C2778690821 @default.
- W2026756305 hasConceptScore W2026756305C2780116568 @default.
- W2026756305 hasConceptScore W2026756305C51872919 @default.