Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026757718> ?p ?o ?g. }
- W2026757718 endingPage "196" @default.
- W2026757718 startingPage "174" @default.
- W2026757718 abstract "Embryonic induction, soluble and insoluble factors, receptors, and signal transduction are orchestrated for the morphogenesis of the cartilage elements. The interaction of cells with the extracellular matrix (ECM) may lead to altered cellular response to morphogens based on the formation of new adhesive contacts, or the uncoupling of cell-matrix interactions. Hyaluronan's influence on cell behavior, and its intimate association with cells are accomplished by a wide variety of specific binding proteins for hyaluronan. The temporal expression of the hyaluronan receptor CD44 (which is expressed as several alternatively spliced variants) may be strategic to many of these cell-matrix interactions during chondrogenesis. CD44 expression is temporally coincident with the reduction of intercellular spaces at the regions of future cartilage deposition. The spatial organization of CD44 at the cell surface may function to establish or regulate the structure of the pericellular matrix dependent on a hyaluronan scaffold. As the ECM is modified during embryogenesis, the cellular response to inductive signals may be altered. An uncoupling of chondrocyte-hyaluronan interaction leads to chondrocytic chondrolysis. Thus, consideration of cell-matrix interactions during chondrogenesis, in the light of our current understanding of the temporal and spatial expression of signaling morphogens, should become a promising focus of future research endeavors." @default.
- W2026757718 created "2016-06-24" @default.
- W2026757718 creator A5029591124 @default.
- W2026757718 date "2003-05-01" @default.
- W2026757718 modified "2023-10-17" @default.
- W2026757718 title "Hyaluronan and CD44: Strategic players for cell-matrix interactions during chondrogenesis and matrix assembly" @default.
- W2026757718 cites W102012657 @default.
- W2026757718 cites W108575403 @default.
- W2026757718 cites W128448010 @default.
- W2026757718 cites W1483126826 @default.
- W2026757718 cites W1484703368 @default.
- W2026757718 cites W1486203466 @default.
- W2026757718 cites W1496679328 @default.
- W2026757718 cites W1500501173 @default.
- W2026757718 cites W1509629462 @default.
- W2026757718 cites W1519926076 @default.
- W2026757718 cites W1521949639 @default.
- W2026757718 cites W1531779321 @default.
- W2026757718 cites W1532065277 @default.
- W2026757718 cites W1553199687 @default.
- W2026757718 cites W1573495239 @default.
- W2026757718 cites W1586971678 @default.
- W2026757718 cites W1598762088 @default.
- W2026757718 cites W1599397384 @default.
- W2026757718 cites W1605923883 @default.
- W2026757718 cites W16102915 @default.
- W2026757718 cites W1617781531 @default.
- W2026757718 cites W167609522 @default.
- W2026757718 cites W1824133708 @default.
- W2026757718 cites W1834622832 @default.
- W2026757718 cites W1847528436 @default.
- W2026757718 cites W1857705665 @default.
- W2026757718 cites W1936873376 @default.
- W2026757718 cites W1953492185 @default.
- W2026757718 cites W1955056721 @default.
- W2026757718 cites W1963649579 @default.
- W2026757718 cites W1965160111 @default.
- W2026757718 cites W1967938623 @default.
- W2026757718 cites W1968486806 @default.
- W2026757718 cites W1972761862 @default.
- W2026757718 cites W1974527403 @default.
- W2026757718 cites W1974531816 @default.
- W2026757718 cites W1974861766 @default.
- W2026757718 cites W1976566500 @default.
- W2026757718 cites W1978514720 @default.
- W2026757718 cites W1980457464 @default.
- W2026757718 cites W1983932174 @default.
- W2026757718 cites W1984449917 @default.
- W2026757718 cites W1985585224 @default.
- W2026757718 cites W1986105465 @default.
- W2026757718 cites W1986677509 @default.
- W2026757718 cites W1987893498 @default.
- W2026757718 cites W1988424812 @default.
- W2026757718 cites W1989709392 @default.
- W2026757718 cites W1989777218 @default.
- W2026757718 cites W1991635667 @default.
- W2026757718 cites W1993485664 @default.
- W2026757718 cites W1994155198 @default.
- W2026757718 cites W1994496279 @default.
- W2026757718 cites W1996197110 @default.
- W2026757718 cites W1997139468 @default.
- W2026757718 cites W1999862888 @default.
- W2026757718 cites W2001217834 @default.
- W2026757718 cites W2001973965 @default.
- W2026757718 cites W2002143767 @default.
- W2026757718 cites W2002468800 @default.
- W2026757718 cites W2002572034 @default.
- W2026757718 cites W2004902219 @default.
- W2026757718 cites W2005457203 @default.
- W2026757718 cites W2006004787 @default.
- W2026757718 cites W2007242612 @default.
- W2026757718 cites W2007430497 @default.
- W2026757718 cites W2012856015 @default.
- W2026757718 cites W2014795139 @default.
- W2026757718 cites W2018140400 @default.
- W2026757718 cites W2018746299 @default.
- W2026757718 cites W2019486380 @default.
- W2026757718 cites W2021580435 @default.
- W2026757718 cites W2023973797 @default.
- W2026757718 cites W2024144069 @default.
- W2026757718 cites W2024910769 @default.
- W2026757718 cites W2025950270 @default.
- W2026757718 cites W2026201824 @default.
- W2026757718 cites W2026414671 @default.
- W2026757718 cites W2027600661 @default.
- W2026757718 cites W2029145511 @default.
- W2026757718 cites W2029584461 @default.
- W2026757718 cites W2029834185 @default.
- W2026757718 cites W2030161444 @default.
- W2026757718 cites W2032380793 @default.
- W2026757718 cites W2032494288 @default.
- W2026757718 cites W2032600611 @default.
- W2026757718 cites W2033403431 @default.
- W2026757718 cites W2034807753 @default.
- W2026757718 cites W2034919108 @default.
- W2026757718 cites W2035038875 @default.
- W2026757718 cites W2035318087 @default.
- W2026757718 cites W2035536358 @default.