FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026759679> ?p ?o ?g. }

• W2026759679 abstract "Adduction of a nitric oxide (NO) moiety (NO•) to cysteines termed as S-nitrosylation (SNO) has emerged as a crucial mechanism for NO signaling crucial for mediating the vascular effects of estrogens. Mitochondrion is a known vascular risk factor; however, the effects of estrogens on mitochondrial SNO are incompletely understood. In this study we determined the effects of estradiol-17β (E2β) on mitochondrial protein SNO in primary human umbilical vein endothelial cells and compared the mitochondrial nitroso-proteomes in E2β- and a NO donor S-nitrosoglutathione (GSNO)-treated cells using a proteomics approach. Treatment with 10 nM E2β and 1 mM GSNO for 30 minutes significantly increased the levels of mitochondrial SNO-proteins. Subcellular localization of SNO-proteins showed mitochondria as the major cellular organelle for protein SNO in response to E2β and GSNO. E2β stimulated mitochondrial endothelial nitric oxide synthase (eNOS) phosphorylation and mitochondrial protein SNO that was enhanced by overexpression of mitochondrion or Golgi, but not membrane targeting eNOS constructs. We identified 11, 32, and 54 SNO-proteins in the mitochondria from the untreated, E2β-, and GSNO-treated human umbilical vein endothelial cells, respectively. Comparisons of the nitroso-proteomes revealed that common and different mitochondrial SNO-proteins were affected by endogenous NO on E2β stimulation and exogenous NO from donor. These SNO-proteins were associated with various mitochondrial functions, including energy and redox regulation, transport, iron homeostasis, translation, mitochondrial morphology, and apoptosis, etc. Collectively, we conclude that estrogens rapidly stimulate protein SNO in endothelial mitochondria via mitochondrial eNOS, providing a mechanism for mediating the vascular effects of estrogens." @default.
• W2026759679 created "2016-06-24" @default.
• W2026759679 creator A5006992570 @default.
• W2026759679 creator A5040683878 @default.
• W2026759679 creator A5059210913 @default.
• W2026759679 creator A5061078231 @default.
• W2026759679 creator A5070754234 @default.
• W2026759679 creator A5087790751 @default.
• W2026759679 date "2014-08-01" @default.
• W2026759679 modified "2023-09-29" @default.
• W2026759679 title "Endogenous NO Upon Estradiol-17β Stimulation and NO Donor Differentially Regulate Mitochondrial S-Nitrosylation in Endothelial Cells" @default.
• W2026759679 cites W1488493608 @default.
• W2026759679 cites W1598629558 @default.
• W2026759679 cites W1964437006 @default.
• W2026759679 cites W1967729440 @default.
• W2026759679 cites W1973626130 @default.
• W2026759679 cites W1976821923 @default.
• W2026759679 cites W1981845473 @default.
• W2026759679 cites W1986038688 @default.
• W2026759679 cites W1989268736 @default.
• W2026759679 cites W1996212178 @default.
• W2026759679 cites W1996310347 @default.
• W2026759679 cites W2003379664 @default.
• W2026759679 cites W2003630942 @default.
• W2026759679 cites W2004724154 @default.
• W2026759679 cites W2005539486 @default.
• W2026759679 cites W2013715338 @default.
• W2026759679 cites W2018205667 @default.
• W2026759679 cites W2018207304 @default.
• W2026759679 cites W2022568707 @default.
• W2026759679 cites W2028573466 @default.
• W2026759679 cites W2036982001 @default.
• W2026759679 cites W2038547356 @default.
• W2026759679 cites W2038709676 @default.
• W2026759679 cites W2042297383 @default.
• W2026759679 cites W2046082610 @default.
• W2026759679 cites W2057740219 @default.
• W2026759679 cites W2061490621 @default.
• W2026759679 cites W2063146732 @default.
• W2026759679 cites W2065773243 @default.
• W2026759679 cites W2066298795 @default.
• W2026759679 cites W2077943167 @default.
• W2026759679 cites W2079217126 @default.
• W2026759679 cites W2080615903 @default.
• W2026759679 cites W2080894377 @default.
• W2026759679 cites W2089884218 @default.
• W2026759679 cites W2091380103 @default.
• W2026759679 cites W2095968162 @default.
• W2026759679 cites W2098810335 @default.
• W2026759679 cites W2099273954 @default.
• W2026759679 cites W2101042964 @default.
• W2026759679 cites W2101771484 @default.
• W2026759679 cites W2105754268 @default.
• W2026759679 cites W2107366065 @default.
• W2026759679 cites W2109110436 @default.
• W2026759679 cites W2113443177 @default.
• W2026759679 cites W2118391959 @default.
• W2026759679 cites W2126788226 @default.
• W2026759679 cites W2127321441 @default.
• W2026759679 cites W2141214120 @default.
• W2026759679 cites W2148290535 @default.
• W2026759679 cites W2158855816 @default.
• W2026759679 cites W2165268250 @default.
• W2026759679 cites W2395675726 @default.
• W2026759679 cites W2793216206 @default.
• W2026759679 doi "https://doi.org/10.1210/en.2013-2174" @default.
• W2026759679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4098011" @default.
• W2026759679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24877627" @default.
• W2026759679 hasPublicationYear "2014" @default.
• W2026759679 type Work @default.
• W2026759679 sameAs 2026759679 @default.
• W2026759679 citedByCount "9" @default.
• W2026759679 countsByYear W20267596792015 @default.
• W2026759679 countsByYear W20267596792016 @default.
• W2026759679 countsByYear W20267596792017 @default.
• W2026759679 countsByYear W20267596792020 @default.
• W2026759679 countsByYear W20267596792022 @default.
• W2026759679 countsByYear W20267596792023 @default.
• W2026759679 crossrefType "journal-article" @default.
• W2026759679 hasAuthorship W2026759679A5006992570 @default.
• W2026759679 hasAuthorship W2026759679A5040683878 @default.
• W2026759679 hasAuthorship W2026759679A5059210913 @default.
• W2026759679 hasAuthorship W2026759679A5061078231 @default.
• W2026759679 hasAuthorship W2026759679A5070754234 @default.
• W2026759679 hasAuthorship W2026759679A5087790751 @default.
• W2026759679 hasBestOaLocation W20267596791 @default.
• W2026759679 hasConcept C134018914 @default.
• W2026759679 hasConcept C16613235 @default.
• W2026759679 hasConcept C181199279 @default.
• W2026759679 hasConcept C202751555 @default.
• W2026759679 hasConcept C2777411675 @default.
• W2026759679 hasConcept C2777553025 @default.
• W2026759679 hasConcept C2779201268 @default.
• W2026759679 hasConcept C28859421 @default.
• W2026759679 hasConcept C519581460 @default.
• W2026759679 hasConcept C55493867 @default.
• W2026759679 hasConcept C74897846 @default.
• W2026759679 hasConcept C75385678 @default.
• W2026759679 hasConcept C86803240 @default.
• W2026759679 hasConcept C95444343 @default.

• next