Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026761123> ?p ?o ?g. }
- W2026761123 endingPage "544" @default.
- W2026761123 startingPage "537" @default.
- W2026761123 abstract "Hepatitis B virus (HBV) mutants with deletions in the preS region have not been evaluated for association with viral genotypes. In a case-control study, HBV DNA samples collected from 80 each of carriers infected with HBV genotype B or C were examined for preS deletions. PreS deletion mutants were found in a total of 37 of 160 (23%) HBV carriers. Carriers with preS deletion mutants were older (56.0 +/- 12.7 vs 49.3 +/- 16.9 years, P < 0.05), were infected more frequently with HBV genotype C (84% vs 40%, P < 0.05), and had more advanced disease, such as liver cirrhosis and hepatocellular carcinoma (54% vs 31%; P < 0.05), than did those without such mutants. In a multivariate analysis, genotype C (odds ratio [OR] = 9.3, P < 0.001) and advanced liver disease (OR = 3.1, P < 0.01) were the most significant variables in association with preS deletions. A direct repeat sequence (TCAGG) was found at the start or at the end of preS1 deletions in 6 of the 20 (30%) cases examined, and preS2 deletions in these cases were clustered over the 5'-terminal half of this region. These results indicate that the development of preS deletion mutants depends on HBV genotypes and that it may be associated with progressive liver disease." @default.
- W2026761123 created "2016-06-24" @default.
- W2026761123 creator A5003312518 @default.
- W2026761123 creator A5008799011 @default.
- W2026761123 creator A5015338865 @default.
- W2026761123 creator A5029936292 @default.
- W2026761123 creator A5039265388 @default.
- W2026761123 creator A5080499677 @default.
- W2026761123 creator A5084495121 @default.
- W2026761123 creator A5086862510 @default.
- W2026761123 creator A5087376756 @default.
- W2026761123 creator A5089141180 @default.
- W2026761123 date "2003-06-02" @default.
- W2026761123 modified "2023-10-14" @default.
- W2026761123 title "Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease" @default.
- W2026761123 cites W1887371688 @default.
- W2026761123 cites W1965000508 @default.
- W2026761123 cites W1971248139 @default.
- W2026761123 cites W1982184546 @default.
- W2026761123 cites W1984513955 @default.
- W2026761123 cites W1988137314 @default.
- W2026761123 cites W1992399796 @default.
- W2026761123 cites W2009759653 @default.
- W2026761123 cites W2013054809 @default.
- W2026761123 cites W2014076755 @default.
- W2026761123 cites W2019475968 @default.
- W2026761123 cites W2024084460 @default.
- W2026761123 cites W2027559511 @default.
- W2026761123 cites W2033704186 @default.
- W2026761123 cites W2037275756 @default.
- W2026761123 cites W2038475476 @default.
- W2026761123 cites W2044729684 @default.
- W2026761123 cites W2047923663 @default.
- W2026761123 cites W2052794955 @default.
- W2026761123 cites W2059132084 @default.
- W2026761123 cites W2068182899 @default.
- W2026761123 cites W2077485054 @default.
- W2026761123 cites W2078381537 @default.
- W2026761123 cites W2084102701 @default.
- W2026761123 cites W2084602326 @default.
- W2026761123 cites W2085800828 @default.
- W2026761123 cites W2089847471 @default.
- W2026761123 cites W2093270380 @default.
- W2026761123 cites W2095745440 @default.
- W2026761123 cites W2100131352 @default.
- W2026761123 cites W2119859499 @default.
- W2026761123 cites W2124731827 @default.
- W2026761123 cites W2128637897 @default.
- W2026761123 cites W2136445954 @default.
- W2026761123 cites W2144375124 @default.
- W2026761123 cites W2153732660 @default.
- W2026761123 cites W2175117246 @default.
- W2026761123 doi "https://doi.org/10.1002/jmv.10428" @default.
- W2026761123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12794715" @default.
- W2026761123 hasPublicationYear "2003" @default.
- W2026761123 type Work @default.
- W2026761123 sameAs 2026761123 @default.
- W2026761123 citedByCount "105" @default.
- W2026761123 countsByYear W20267611232012 @default.
- W2026761123 countsByYear W20267611232013 @default.
- W2026761123 countsByYear W20267611232014 @default.
- W2026761123 countsByYear W20267611232015 @default.
- W2026761123 countsByYear W20267611232016 @default.
- W2026761123 countsByYear W20267611232017 @default.
- W2026761123 countsByYear W20267611232018 @default.
- W2026761123 countsByYear W20267611232019 @default.
- W2026761123 countsByYear W20267611232020 @default.
- W2026761123 countsByYear W20267611232021 @default.
- W2026761123 countsByYear W20267611232023 @default.
- W2026761123 crossrefType "journal-article" @default.
- W2026761123 hasAuthorship W2026761123A5003312518 @default.
- W2026761123 hasAuthorship W2026761123A5008799011 @default.
- W2026761123 hasAuthorship W2026761123A5015338865 @default.
- W2026761123 hasAuthorship W2026761123A5029936292 @default.
- W2026761123 hasAuthorship W2026761123A5039265388 @default.
- W2026761123 hasAuthorship W2026761123A5080499677 @default.
- W2026761123 hasAuthorship W2026761123A5084495121 @default.
- W2026761123 hasAuthorship W2026761123A5086862510 @default.
- W2026761123 hasAuthorship W2026761123A5087376756 @default.
- W2026761123 hasAuthorship W2026761123A5089141180 @default.
- W2026761123 hasConcept C104317684 @default.
- W2026761123 hasConcept C126322002 @default.
- W2026761123 hasConcept C135763542 @default.
- W2026761123 hasConcept C143065580 @default.
- W2026761123 hasConcept C159047783 @default.
- W2026761123 hasConcept C2522874641 @default.
- W2026761123 hasConcept C2777075537 @default.
- W2026761123 hasConcept C2777214474 @default.
- W2026761123 hasConcept C2777382497 @default.
- W2026761123 hasConcept C2778019345 @default.
- W2026761123 hasConcept C2778600374 @default.
- W2026761123 hasConcept C2780593183 @default.
- W2026761123 hasConcept C2780617729 @default.
- W2026761123 hasConcept C54355233 @default.
- W2026761123 hasConcept C55493867 @default.
- W2026761123 hasConcept C71924100 @default.
- W2026761123 hasConcept C86803240 @default.
- W2026761123 hasConceptScore W2026761123C104317684 @default.