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- W2026768052 abstract "In St. Louis, near the riverfront, looms the Gateway Arch, the portal to the West, the nineteenth century frontier. Our current knowledge of the ovulatory process is reminiscent of the early exploration of the American West: we have the ability to conduct this exploration and the need to expand our understanding of this strange new science, but still we are uncertain of our final destination. The history of ovulation induction has been characterized by a continuing effort to reduce the limits of the unknown, to constantly expand into new a r ea s f ron t i e r s t ha t define our limits, and to open new areas for productive activities. The Frontiers in Ovulation Induction symposia presentations that are reviewed in this supplement explored the borders of our knowledge in this field. -The authors of this supplement have reviewed their own contributions, as well as those of many others, to provide a scientific foundation for the advancement of clinical medicine. Drs. Gregory Erickson and Douglas Danforth give excellent examples of evolving areas of knowledge about the granulosa cell and its functions. The role of growth factors in the ovary, which is a complex topic, remains for the most part unexplored. Likewise, many experiments need to be performed to better our understanding of the roles of cytokines, inhibins, activins, and steroids in the ovulatory process. Even after we understand each of these compounds in normal, successful reproduction, there will still be much to discover in the myriad pathologic processes that prevent or impede ovulation and pregnancy. Despite our relatively primitive understanding of the ovulatory process, many treatments are being applied clinically. Most anovulatory patients treated during the past 3 decades have used oral agents. The evolution of injectable medicines, discussed by Dr. Michael Gast, suggests possible advances that genetic engineering will allow. Not only will injectable drugs of the future be purer preparations, but it may be possible to have better control of cycle events, easier administration of agents, and drugs that will be tailored to the exact needs of the patient." @default.
- W2026768052 created "2016-06-24" @default.
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- W2026768052 date "1995-02-01" @default.
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- W2026768052 title "Concluding remarks: Exploring new frontiers in ovulation induction" @default.
- W2026768052 doi "https://doi.org/10.1016/0002-9378(95)90157-4" @default.
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