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• W2026770360 endingPage "4619" @default.
• W2026770360 startingPage "4614" @default.
• W2026770360 abstract "The DNA repair enzyme, O 6 -methylguanine DNA methyltransferase (MGMT) is responsible for repair of damage induced by alkylating agents that produce adducts at O 6 -guanine in DNA. Although the MGMT gene promoter has housekeeping gene promoter characteristics, unlike these genes which are expressed at a constant level, MGMT transcriptional activity varies between cell types. During an attempt to identify regions of the MGMT regulatory sequence sensitive to variations in transcription factors between cell types, we have identified a 59 bp enhancer which is required for efficient MGMT promoter function. This fragment produced increased transcriptional activity in reporter gene constructs containing either the MGMT or UMP-synthase promoter when transfected into either of two cell lines; it seems therefore that this enhancer may interact with relatively common trans-acting factors. Functional activity is only detected when the enhancer is in ‘cis’ with respect to the promoter, suggesting that complexes are formed between proteins bound to the enhancer and promoter sequences. We propose that the enhancer-binding protein may be a novel transcription factor since there are no obvious consensus sequences within the 59 bp sequence for known DNA-binding proteins." @default.
• W2026770360 created "2016-06-24" @default.
• W2026770360 creator A5009637029 @default.
• W2026770360 creator A5080433035 @default.
• W2026770360 creator A5081391322 @default.
• W2026770360 date "1994-01-01" @default.
• W2026770360 modified "2023-10-18" @default.
• W2026770360 title "Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O⁶-methylguanine DNA methyltransferease gene" @default.
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• W2026770360 doi "https://doi.org/10.1093/nar/22.22.4614" @default.
• W2026770360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/308508" @default.
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• W2026770360 hasPublicationYear "1994" @default.
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