FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026776441> ?p ?o ?g. }

• W2026776441 endingPage "46" @default.
• W2026776441 startingPage "41" @default.
• W2026776441 abstract "Ketamine, which is a non-competitive NMDA receptor antagonist, has been used as a dissociative anesthetic agent. However, chronic use of ketamine produces psychotomimetic effects, such as nightmares, hallucination and delusion. Therefore, the present study was designed to ascertain the role of the NMDA receptor and sigma receptor in the discriminative stimulus effect induced by ketamine. Fischer 344 rats were trained to discriminate between ketamine (5 mg/kg, i.p.) and saline under a fixed-ratio 10 food-reinforced procedure. Non-competitive antagonists for both NR2A- and NR2B-containing NMDA receptors, such as phencyclidine (0.1--1 mg/kg, i.p.) and dizocilpine (3--30 microg/kg, i.p.), and the NR2A-containing NMDA receptor-preferred antagonist dextromethorphan (3--56 mg/kg, i.p.) fully substituted for the ketamine cue in a dose-dependent manner. By contrast, the NR2B-containing NMDA receptor antagonist ifenprodil (5--20 mg/kg, i.p.) exhibited no generalization. Additionally, the competitive NMDA antagonist 3-[(+/-)-2-carboxypiperazine-4-yl] propyl-1-phosphonic acid ((+/-)-CPP; 0.3--5.6 mg/kg, i.p.) and a sigma receptor ligand DTG (0.3--3 mg/kg, s.c.) displayed no generalization to the ketamine cue. These results suggest that NR1/NR2A subunit containing NMDA antagonism may be critical for the production of the ketamine cue." @default.
• W2026776441 created "2016-06-24" @default.
• W2026776441 creator A5001653266 @default.
• W2026776441 creator A5029241280 @default.
• W2026776441 creator A5070209281 @default.
• W2026776441 creator A5073433406 @default.
• W2026776441 creator A5080259607 @default.
• W2026776441 date "2001-06-01" @default.
• W2026776441 modified "2023-09-27" @default.
• W2026776441 title "Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine" @default.
• W2026776441 cites W15515072 @default.
• W2026776441 cites W1965870634 @default.
• W2026776441 cites W1984859505 @default.
• W2026776441 cites W1988836643 @default.
• W2026776441 cites W1990625157 @default.
• W2026776441 cites W1995958112 @default.
• W2026776441 cites W2001189298 @default.
• W2026776441 cites W2003179182 @default.
• W2026776441 cites W2021056513 @default.
• W2026776441 cites W2025605560 @default.
• W2026776441 cites W2028884770 @default.
• W2026776441 cites W2032187584 @default.
• W2026776441 cites W2036517215 @default.
• W2026776441 cites W2040367183 @default.
• W2026776441 cites W2040936201 @default.
• W2026776441 cites W2053980736 @default.
• W2026776441 cites W2054710811 @default.
• W2026776441 cites W2061633232 @default.
• W2026776441 cites W2062592895 @default.
• W2026776441 cites W2066794669 @default.
• W2026776441 cites W2067555546 @default.
• W2026776441 cites W2075970322 @default.
• W2026776441 cites W2100040827 @default.
• W2026776441 cites W2138368199 @default.
• W2026776441 cites W2158137297 @default.
• W2026776441 cites W2165386990 @default.
• W2026776441 cites W2169055778 @default.
• W2026776441 doi "https://doi.org/10.1016/s0014-2999(01)01089-5" @default.
• W2026776441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11438305" @default.
• W2026776441 hasPublicationYear "2001" @default.
• W2026776441 type Work @default.
• W2026776441 sameAs 2026776441 @default.
• W2026776441 citedByCount "24" @default.
• W2026776441 countsByYear W20267764412012 @default.
• W2026776441 countsByYear W20267764412013 @default.
• W2026776441 countsByYear W20267764412015 @default.
• W2026776441 countsByYear W20267764412016 @default.
• W2026776441 countsByYear W20267764412017 @default.
• W2026776441 countsByYear W20267764412019 @default.
• W2026776441 countsByYear W20267764412021 @default.
• W2026776441 countsByYear W20267764412022 @default.
• W2026776441 crossrefType "journal-article" @default.
• W2026776441 hasAuthorship W2026776441A5001653266 @default.
• W2026776441 hasAuthorship W2026776441A5029241280 @default.
• W2026776441 hasAuthorship W2026776441A5070209281 @default.
• W2026776441 hasAuthorship W2026776441A5073433406 @default.
• W2026776441 hasAuthorship W2026776441A5080259607 @default.
• W2026776441 hasConcept C170493617 @default.
• W2026776441 hasConcept C185592680 @default.
• W2026776441 hasConcept C2776885963 @default.
• W2026776441 hasConcept C2777052854 @default.
• W2026776441 hasConcept C2777836312 @default.
• W2026776441 hasConcept C2778122271 @default.
• W2026776441 hasConcept C2778851735 @default.
• W2026776441 hasConcept C2779484449 @default.
• W2026776441 hasConcept C2780376555 @default.
• W2026776441 hasConcept C2780795376 @default.
• W2026776441 hasConcept C2781065190 @default.
• W2026776441 hasConcept C2781245242 @default.
• W2026776441 hasConcept C42219234 @default.
• W2026776441 hasConcept C55493867 @default.
• W2026776441 hasConcept C67018056 @default.
• W2026776441 hasConcept C71924100 @default.
• W2026776441 hasConcept C86811712 @default.
• W2026776441 hasConcept C98274493 @default.
• W2026776441 hasConceptScore W2026776441C170493617 @default.
• W2026776441 hasConceptScore W2026776441C185592680 @default.
• W2026776441 hasConceptScore W2026776441C2776885963 @default.
• W2026776441 hasConceptScore W2026776441C2777052854 @default.
• W2026776441 hasConceptScore W2026776441C2777836312 @default.
• W2026776441 hasConceptScore W2026776441C2778122271 @default.
• W2026776441 hasConceptScore W2026776441C2778851735 @default.
• W2026776441 hasConceptScore W2026776441C2779484449 @default.
• W2026776441 hasConceptScore W2026776441C2780376555 @default.
• W2026776441 hasConceptScore W2026776441C2780795376 @default.
• W2026776441 hasConceptScore W2026776441C2781065190 @default.
• W2026776441 hasConceptScore W2026776441C2781245242 @default.
• W2026776441 hasConceptScore W2026776441C42219234 @default.
• W2026776441 hasConceptScore W2026776441C55493867 @default.
• W2026776441 hasConceptScore W2026776441C67018056 @default.
• W2026776441 hasConceptScore W2026776441C71924100 @default.
• W2026776441 hasConceptScore W2026776441C86811712 @default.
• W2026776441 hasConceptScore W2026776441C98274493 @default.
• W2026776441 hasIssue "1" @default.
• W2026776441 hasLocation W20267764411 @default.
• W2026776441 hasLocation W20267764412 @default.
• W2026776441 hasOpenAccess W2026776441 @default.
• W2026776441 hasPrimaryLocation W20267764411 @default.

• next