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• W2026780899 abstract "Experiments were undertaken to investigate the role of intracellular Ca2+ stores in the regulation of Ca2+ uptake in the cultured B-lymphocytic cell line CH12.LX.C4.5F5. Release of intracellular Ca2+ stores by addition of thapsigargin was accompanied by a biphasic increase in intracellular calcium concentration ([Ca2+]i). The initial rise in [Ca2+]i was due to release of Ca2+ from intracellular stores as determined by its maintenance in the absence of extracellular Ca2+. The secondary phase was (1) dependent on the presence of extracellular Ca2+, (2) inhibited by 5 mM extracellular Ni2+, and (3) inhibited by high K+, consistent with electrogenic Ca2+ uptake from the extracellular medium. In order to more accurate y investigate the electrogenic nature of this pathway we measured the membrane potential changes accompanying Ca2+ influx stimulated by release of Ca2+ from intracellular stores using bis(1,3-diethylthiobarbituric acid trimethine) oxonol in Bapta-loaded cells. Addition of 5 mM Ca2+ to cells pretreated with doses of thapsigargin or ionomycin shown to release intracellular Ca2+ stores induced a depolarization which was (1) dependent upon extracellular Ca2+, (2) abolished by 5 mM Ni2+, (3) independent of extracellular Na+, and (4) dependent upon Bapta loading. This depolarization was followed by a charybdotoxin-sensitive repolarization consistent with secondary activation of K+ channels. Changes in [Ca2+]i monitored under identical conditions were monitored fluorimetrically using indo-1 and were found to correlate with the changes in Em. On the basis of these data we conclude that an electrogenic Ca2+ -permeable pathway exists in this B-lymphocytic cell line which is regulated by the degree of filling of an internal Ca2+ -store. © 1994 Wiley-Liss, Inc." @default.
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• W2026780899 title "Role of intracellular Ca2+ stores in the regulation of electrogenic plasma membrane Ca2+ uptake in a B-lymphocytic cell line" @default.
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• W2026780899 doi "https://doi.org/10.1002/jcp.1041610307" @default.
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