Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026792007> ?p ?o ?g. }
- W2026792007 endingPage "583" @default.
- W2026792007 startingPage "566" @default.
- W2026792007 abstract "This study aimed to determine the effect of C-type natriuretic peptide (CNP) overexpression on craniofacial growth during the pubertal growth period in mice.Six-week-old C57BL/6 mice were injected with pLIVE-Empty vectors (Control mice) and pLIVE-NPPC vectors (CNP mice) using the hydrodynamic method. Morphological analyses were performed at the age of 12 weeks.Micro–computed tomography (µCT) images showed significant (p < 0.05) hyperplasia in the maxilla along the sagittal plane (CNP mice: 13.754 mm, Control mice: 13.215 mm). Further, the images revealed significant bone overgrowth in the sagittal direction in the sphenoid (CNP mice: 6.936 mm, Control mice: 6.411 mm) and occipital (CNP mice: 4.051 mm, Control mice: 3.784 mm) bones in the CNP mice compared with that in the Control mice. Compared with SAP-Nppc-Tg mice in previous studies, although there was no effect on nose length and nasal bone length, the effect was sufficient to improve craniofacial hypogrowth. Furthermore, CNP promoted sagittal cranial growth by increasing the thickness of the spheno-occipital synchondrosis in organ cultures and nasal septal cartilage in micromass cultures, which were derived from 6-week-old mice.We have previously shown that the elevated blood levels of CNP from the neonatal period affect midfacial skeletogenesis by promoting endochondral ossification using mice (SAP-Nppc-Tg mice). The overexpression of CNP, even in 6-weeks-old mice, promoted growth in the sagittal direction within the maxillary region. These findings indicate the therapeutic potential of CNP for the treatment of midfacial hypoplasia during the pubertal growth spurt." @default.
- W2026792007 created "2016-06-24" @default.
- W2026792007 creator A5044247935 @default.
- W2026792007 date "1968-08-01" @default.
- W2026792007 modified "2023-09-25" @default.
- W2026792007 title "Cranial growth centers: Facts or fallacies?" @default.
- W2026792007 cites W1508283088 @default.
- W2026792007 cites W1836732010 @default.
- W2026792007 cites W1964080883 @default.
- W2026792007 cites W1967211734 @default.
- W2026792007 cites W1967708467 @default.
- W2026792007 cites W1967813894 @default.
- W2026792007 cites W1971940957 @default.
- W2026792007 cites W1973405473 @default.
- W2026792007 cites W1976335335 @default.
- W2026792007 cites W1979091627 @default.
- W2026792007 cites W1986791970 @default.
- W2026792007 cites W1988534247 @default.
- W2026792007 cites W1989625661 @default.
- W2026792007 cites W1991239605 @default.
- W2026792007 cites W1995457569 @default.
- W2026792007 cites W1995602231 @default.
- W2026792007 cites W2004245053 @default.
- W2026792007 cites W2015170995 @default.
- W2026792007 cites W2018212101 @default.
- W2026792007 cites W2021936400 @default.
- W2026792007 cites W2025348809 @default.
- W2026792007 cites W2025788859 @default.
- W2026792007 cites W2028618195 @default.
- W2026792007 cites W2033021137 @default.
- W2026792007 cites W2033055177 @default.
- W2026792007 cites W2035121757 @default.
- W2026792007 cites W2035839160 @default.
- W2026792007 cites W2038905435 @default.
- W2026792007 cites W2039017728 @default.
- W2026792007 cites W2044169158 @default.
- W2026792007 cites W2048518053 @default.
- W2026792007 cites W2053002734 @default.
- W2026792007 cites W2056039463 @default.
- W2026792007 cites W2061413739 @default.
- W2026792007 cites W2065838634 @default.
- W2026792007 cites W2070152319 @default.
- W2026792007 cites W2070384156 @default.
- W2026792007 cites W2076837933 @default.
- W2026792007 cites W2078784188 @default.
- W2026792007 cites W2079211043 @default.
- W2026792007 cites W2082256147 @default.
- W2026792007 cites W2088247119 @default.
- W2026792007 cites W2092276626 @default.
- W2026792007 cites W2093374784 @default.
- W2026792007 cites W2094295811 @default.
- W2026792007 cites W2095946229 @default.
- W2026792007 cites W2112205951 @default.
- W2026792007 cites W2118323443 @default.
- W2026792007 cites W2126626234 @default.
- W2026792007 cites W2127698231 @default.
- W2026792007 cites W2142847010 @default.
- W2026792007 cites W2143390212 @default.
- W2026792007 cites W2156158273 @default.
- W2026792007 cites W2276015403 @default.
- W2026792007 cites W2280366158 @default.
- W2026792007 cites W2404508785 @default.
- W2026792007 doi "https://doi.org/10.1016/0002-9416(68)90177-2" @default.
- W2026792007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4874446" @default.
- W2026792007 hasPublicationYear "1968" @default.
- W2026792007 type Work @default.
- W2026792007 sameAs 2026792007 @default.
- W2026792007 citedByCount "77" @default.
- W2026792007 countsByYear W20267920072012 @default.
- W2026792007 countsByYear W20267920072014 @default.
- W2026792007 countsByYear W20267920072015 @default.
- W2026792007 countsByYear W20267920072016 @default.
- W2026792007 countsByYear W20267920072017 @default.
- W2026792007 countsByYear W20267920072020 @default.
- W2026792007 countsByYear W20267920072022 @default.
- W2026792007 crossrefType "journal-article" @default.
- W2026792007 hasAuthorship W2026792007A5044247935 @default.
- W2026792007 hasConcept C105702510 @default.
- W2026792007 hasConcept C118552586 @default.
- W2026792007 hasConcept C122246415 @default.
- W2026792007 hasConcept C126322002 @default.
- W2026792007 hasConcept C134018914 @default.
- W2026792007 hasConcept C178910020 @default.
- W2026792007 hasConcept C17938293 @default.
- W2026792007 hasConcept C2777562237 @default.
- W2026792007 hasConcept C2780550940 @default.
- W2026792007 hasConcept C2781245598 @default.
- W2026792007 hasConcept C71924100 @default.
- W2026792007 hasConceptScore W2026792007C105702510 @default.
- W2026792007 hasConceptScore W2026792007C118552586 @default.
- W2026792007 hasConceptScore W2026792007C122246415 @default.
- W2026792007 hasConceptScore W2026792007C126322002 @default.
- W2026792007 hasConceptScore W2026792007C134018914 @default.
- W2026792007 hasConceptScore W2026792007C178910020 @default.
- W2026792007 hasConceptScore W2026792007C17938293 @default.
- W2026792007 hasConceptScore W2026792007C2777562237 @default.
- W2026792007 hasConceptScore W2026792007C2780550940 @default.
- W2026792007 hasConceptScore W2026792007C2781245598 @default.