Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026793582> ?p ?o ?g. }
- W2026793582 endingPage "408" @default.
- W2026793582 startingPage "401" @default.
- W2026793582 abstract "When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPA gene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA. When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPA gene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA. angiotensin. bone marrow derived mast cell. carboxypeptidase. connective tissue mast cell. endogenous carboxypeptidase inhibitor. endothelin 1. low density lipoprotein. leukotriene. mast cell. mast cell carboxypeptidase A. mucosal mast cell. mouse mast cell protease. N-deacetylase/N-sulfotransferase. potato carboxypeptidase inhibitor. tissue carboxypeptidase inhibitor." @default.
- W2026793582 created "2016-06-24" @default.
- W2026793582 creator A5004646639 @default.
- W2026793582 creator A5004723894 @default.
- W2026793582 creator A5007679233 @default.
- W2026793582 creator A5078126056 @default.
- W2026793582 date "2009-08-01" @default.
- W2026793582 modified "2023-10-02" @default.
- W2026793582 title "Novel insights into the biological function of mast cell carboxypeptidase A" @default.
- W2026793582 cites W146090589 @default.
- W2026793582 cites W1490104408 @default.
- W2026793582 cites W1499511494 @default.
- W2026793582 cites W1501230571 @default.
- W2026793582 cites W1501356685 @default.
- W2026793582 cites W1505318371 @default.
- W2026793582 cites W1507041174 @default.
- W2026793582 cites W1512371595 @default.
- W2026793582 cites W1519269060 @default.
- W2026793582 cites W1537377527 @default.
- W2026793582 cites W1550422318 @default.
- W2026793582 cites W1557019060 @default.
- W2026793582 cites W1568439447 @default.
- W2026793582 cites W1572929810 @default.
- W2026793582 cites W1574017432 @default.
- W2026793582 cites W1578107688 @default.
- W2026793582 cites W1585450904 @default.
- W2026793582 cites W1588605187 @default.
- W2026793582 cites W1599496006 @default.
- W2026793582 cites W1603013239 @default.
- W2026793582 cites W1607581180 @default.
- W2026793582 cites W1966472906 @default.
- W2026793582 cites W1967901291 @default.
- W2026793582 cites W1968908298 @default.
- W2026793582 cites W1971846568 @default.
- W2026793582 cites W1975068237 @default.
- W2026793582 cites W1975366109 @default.
- W2026793582 cites W1975996690 @default.
- W2026793582 cites W1976229113 @default.
- W2026793582 cites W1982256713 @default.
- W2026793582 cites W1985703908 @default.
- W2026793582 cites W1998356424 @default.
- W2026793582 cites W1998533172 @default.
- W2026793582 cites W1999391252 @default.
- W2026793582 cites W2001175660 @default.
- W2026793582 cites W2002361100 @default.
- W2026793582 cites W2013083986 @default.
- W2026793582 cites W2017220914 @default.
- W2026793582 cites W2026028836 @default.
- W2026793582 cites W2029830646 @default.
- W2026793582 cites W2038960406 @default.
- W2026793582 cites W2047560583 @default.
- W2026793582 cites W2048338013 @default.
- W2026793582 cites W2051803528 @default.
- W2026793582 cites W2053162740 @default.
- W2026793582 cites W2056821174 @default.
- W2026793582 cites W2060501184 @default.
- W2026793582 cites W2064180188 @default.
- W2026793582 cites W2064815391 @default.
- W2026793582 cites W2065375178 @default.
- W2026793582 cites W2069429539 @default.
- W2026793582 cites W2069738049 @default.
- W2026793582 cites W2071324084 @default.
- W2026793582 cites W2075712840 @default.
- W2026793582 cites W2077169684 @default.
- W2026793582 cites W2082798390 @default.
- W2026793582 cites W2085825003 @default.
- W2026793582 cites W2090394546 @default.
- W2026793582 cites W2095142211 @default.
- W2026793582 cites W2097120145 @default.
- W2026793582 cites W2107153285 @default.
- W2026793582 cites W2118420320 @default.
- W2026793582 cites W2136851205 @default.
- W2026793582 cites W2150473906 @default.
- W2026793582 cites W2152782018 @default.
- W2026793582 cites W2153831976 @default.
- W2026793582 cites W2159421923 @default.
- W2026793582 cites W2162992359 @default.
- W2026793582 cites W2170629792 @default.
- W2026793582 cites W2258506980 @default.
- W2026793582 cites W2289293329 @default.
- W2026793582 cites W2414984764 @default.
- W2026793582 cites W4246049786 @default.
- W2026793582 doi "https://doi.org/10.1016/j.it.2009.04.008" @default.
- W2026793582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19643669" @default.
- W2026793582 hasPublicationYear "2009" @default.
- W2026793582 type Work @default.
- W2026793582 sameAs 2026793582 @default.
- W2026793582 citedByCount "67" @default.
- W2026793582 countsByYear W20267935822012 @default.
- W2026793582 countsByYear W20267935822013 @default.
- W2026793582 countsByYear W20267935822014 @default.
- W2026793582 countsByYear W20267935822015 @default.
- W2026793582 countsByYear W20267935822016 @default.
- W2026793582 countsByYear W20267935822017 @default.
- W2026793582 countsByYear W20267935822018 @default.
- W2026793582 countsByYear W20267935822019 @default.
- W2026793582 countsByYear W20267935822020 @default.
- W2026793582 countsByYear W20267935822021 @default.