FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026794430> ?p ?o ?g. }

• W2026794430 endingPage "41" @default.
• W2026794430 startingPage "41" @default.
• W2026794430 abstract "Context: Neuroblastoma is a high-grade malignancy of childhood; it is chemo- and radio-sensitive, but prone to relapse after initial remission. Aim : The aim of this study was to document the impact of first- or second-line radioionated [ 131 I] meta-iodobenzylguanidine ( 131 I-MIBG) therapy or chemotherapy alone on the short-term response and long-term survival in untreated children and to further characterize the side-effects of MIBG treatment. Materials and Methods: In this interventional randomized controlled study, 123 children with advanced neuroblastoma were divided into three groups according to the treatment strategy: 65 were treated by chemotherapy alone (group I), 30 children who were not responding or had relapsed after chemotherapy were treated by second-line 131 I-MIBG (group II), and 28 children were treated by 131 I-MIBG as first-line from the start (group III). External beam radiotherapy was given to bone and brain secondaries when detected. Staging work up was done before, during, and after management with a follow-up period of 5 years. Statistical Analysis Used: All statistical tests were done using Whitney test for the continuous variants to compare the same group pre- and post-therapy. Total actuarial survival and disease-free survival were calculated using Kaplan-Meier analysis. Results: The number of treatments with 131 I-MIBG varied between 1 and 4 per patient (mean 3). Toxicity was seldom severe. Mainly myelosuppression was noticed. Response was documented before surgery for the primary tumor was performed. There was 9, 6, and 14 complete response (CR); 10, 18, and 16 partial responses (PR); 3, 2, and 23 with a stable disease (SD); and 6, 4, and 12 progressed in each group, respectively. Total actuarial survival was found to have a median of nearly 60, 55, and 33 months for groups I, II, and III, respectively, with a statistical significant difference between the three groups. Conclusion: The current study showed the effectiveness of MIBG as a first-line treatment in the management of locally advanced neuroblastoma cases with limited metastasis as initial response and long-term survival for the cases was favorable, while in cases with multiple metastases, chemotherapy should be given first-line and, in case of failure or relapse, second-line MIBG therapy is warranted." @default.
• W2026794430 created "2016-06-24" @default.
• W2026794430 creator A5025844602 @default.
• W2026794430 creator A5056827028 @default.
• W2026794430 creator A5067927959 @default.
• W2026794430 creator A5076318872 @default.
• W2026794430 date "2013-01-01" @default.
• W2026794430 modified "2023-09-26" @default.
• W2026794430 title "Management of neuroblastoma. Comparative study between first- and second-line radioionated meta-iodobenzylguanidine therapy and chemotherapy alone" @default.
• W2026794430 doi "https://doi.org/10.4103/2278-0513.110777" @default.
• W2026794430 hasPublicationYear "2013" @default.
• W2026794430 type Work @default.
• W2026794430 sameAs 2026794430 @default.
• W2026794430 citedByCount "1" @default.
• W2026794430 countsByYear W20267944302017 @default.
• W2026794430 crossrefType "journal-article" @default.
• W2026794430 hasAuthorship W2026794430A5025844602 @default.
• W2026794430 hasAuthorship W2026794430A5056827028 @default.
• W2026794430 hasAuthorship W2026794430A5067927959 @default.
• W2026794430 hasAuthorship W2026794430A5076318872 @default.
• W2026794430 hasConcept C126322002 @default.
• W2026794430 hasConcept C141071460 @default.
• W2026794430 hasConcept C143998085 @default.
• W2026794430 hasConcept C151730666 @default.
• W2026794430 hasConcept C168563851 @default.
• W2026794430 hasConcept C2776694085 @default.
• W2026794430 hasConcept C2776715637 @default.
• W2026794430 hasConcept C2779343474 @default.
• W2026794430 hasConcept C2779399171 @default.
• W2026794430 hasConcept C509974204 @default.
• W2026794430 hasConcept C54355233 @default.
• W2026794430 hasConcept C71924100 @default.
• W2026794430 hasConcept C81885089 @default.
• W2026794430 hasConcept C86803240 @default.
• W2026794430 hasConceptScore W2026794430C126322002 @default.
• W2026794430 hasConceptScore W2026794430C141071460 @default.
• W2026794430 hasConceptScore W2026794430C143998085 @default.
• W2026794430 hasConceptScore W2026794430C151730666 @default.
• W2026794430 hasConceptScore W2026794430C168563851 @default.
• W2026794430 hasConceptScore W2026794430C2776694085 @default.
• W2026794430 hasConceptScore W2026794430C2776715637 @default.
• W2026794430 hasConceptScore W2026794430C2779343474 @default.
• W2026794430 hasConceptScore W2026794430C2779399171 @default.
• W2026794430 hasConceptScore W2026794430C509974204 @default.
• W2026794430 hasConceptScore W2026794430C54355233 @default.
• W2026794430 hasConceptScore W2026794430C71924100 @default.
• W2026794430 hasConceptScore W2026794430C81885089 @default.
• W2026794430 hasConceptScore W2026794430C86803240 @default.
• W2026794430 hasIssue "1" @default.
• W2026794430 hasLocation W20267944301 @default.
• W2026794430 hasOpenAccess W2026794430 @default.
• W2026794430 hasPrimaryLocation W20267944301 @default.
• W2026794430 hasRelatedWork W1505417176 @default.
• W2026794430 hasRelatedWork W153610466 @default.
• W2026794430 hasRelatedWork W2085902464 @default.
• W2026794430 hasRelatedWork W2357763740 @default.
• W2026794430 hasRelatedWork W2404042595 @default.
• W2026794430 hasRelatedWork W2407189953 @default.
• W2026794430 hasRelatedWork W2471383713 @default.
• W2026794430 hasRelatedWork W3008653475 @default.
• W2026794430 hasRelatedWork W3029134543 @default.
• W2026794430 hasRelatedWork W4317391509 @default.
• W2026794430 hasVolume "2" @default.
• W2026794430 isParatext "false" @default.
• W2026794430 isRetracted "false" @default.
• W2026794430 magId "2026794430" @default.
• W2026794430 workType "article" @default.