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- W2026822079 abstract "The molecular layer of the cerebellar cortex contains high levels of the enzyme 5′-nucleotidase (EC 3.1.3.5), localized predominantly to Bergmann glia. In the present study, histochemical methods have been employed to examine the distribution of cerebellar 5′-nucleotidase in mice of two separate mutant strains in which Purkinje cells are eliminated selectively. In homozygous ‘Purkinje cell degeneration’ (pcd) and ‘nervous’ (nr) mice, molecular layer 5′-nucleotidase is greatly reduced and residual enzyme activity in colocalized with surviving Purkinje cells. These results suggest strongly that the expression of 5′-nucleotidase activity by Bergmann glia is under the inductive influence of their associated Purkinje cells." @default.
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- W2026822079 date "1986-09-01" @default.
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- W2026822079 title "5′-Nucleotidase of cerebellar molecular layer: Reduction in purkinje cell-deficient mutant mice" @default.
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- W2026822079 doi "https://doi.org/10.1016/0165-3806(86)90085-4" @default.
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