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- W2026828265 abstract "In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing comparative protein structure prediction methods, we are now able to quantify the relationship between sequence and structure conservation in RNA.Here we introduce an all-against-all sequence- and three-dimensional (3D) structure-based comparison of a representative set of RNA structures, which have allowed us to quantitatively confirm that: (i) there is a measurable relationship between sequence and structure conservation that weakens for alignments resulting in below 60% sequence identity, (ii) evolution tends to conserve more RNA structure than sequence, and (iii) there is a twilight zone for RNA homology detection.The computational analysis here presented quantitatively describes the relationship between sequence and structure for RNA molecules and defines a twilight zone region for detecting RNA homology. Our work could represent the theoretical basis and limitations for future developments in comparative RNA 3D structure prediction." @default.
- W2026828265 created "2016-06-24" @default.
- W2026828265 creator A5029911656 @default.
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- W2026828265 date "2010-06-15" @default.
- W2026828265 modified "2023-10-18" @default.
- W2026828265 title "Quantifying the relationship between sequence and three-dimensional structure conservation in RNA" @default.
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- W2026828265 doi "https://doi.org/10.1186/1471-2105-11-322" @default.
- W2026828265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2904352" @default.
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