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• W2026833193 abstract "I read the article by Yamashita and associates with interest. The article described advantages of reduced-fluence photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV). 1 Yamashita A. Shiraga F. Shiragami C. et al. One-year results of reduced-fluence photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2010; 149: 465-471 Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar I would like to comment about the application of PDT in PCV. PDT is associated with several disadvantages. First, PCV often presents as multiple widely distributed lesions, so it may be difficult to treat all lesions, including multiple polyps and interconnecting vessels, with a single beam of PDT. Treatment of leaking polypoidal dilations only, without treating the entire vascular complex, can result in persistence or worsening of exudation. Second, it can be difficult to treat nodules in the peripapillary area with a round PDT beam. Third, features commonly associated with PCV such as a large PED or a large submacular hemorrhage usually are not amenable to PDT treatment. Fourth, PCV tends to recur repeatedly, so multiple PDT treatments are often necessary, which can increase the risk of long-term choroidal atrophy. Cases of massive subretinal or suprachoroidal hemorrhage have been reported soon after PDT. 2 Lee S.Y. Kim J.G. Joe S.G. et al. The therapeutic effects of bevacizumab in patients with polypoidal choroidal vasculopathy. Korean J Ophthalmol. 2008; 22: 92-99 Crossref PubMed Scopus (59) Google Scholar Even 50% reduced light-fluence PDT can produce a retinal pigment epithelial tear in pigment epithelial detachment. 3 Kim S.W. Oh J. Oh I.K. et al. Retinal pigment epithelial tear after half fluence PDT for serous pigment epithelial detachment in central serous chorioretinopathy. Ophthalmic Surg Lasers Imaging. 2009; 40: 300-303 Crossref Scopus (36) Google Scholar One-Year Results of Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal VasculopathyAmerican Journal of OphthalmologyVol. 149Issue 3PreviewTo report 1-year results of reduced-fluence photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) in Japanese patients. Full-Text PDF ReplyAmerican Journal of OphthalmologyVol. 150Issue 3PreviewWe thank Dr Chhablani for his interest in and comments on our article. There seems to be a racial difference in clinical characteristics of polypoidalchoroidal vasculopathy (PCV) among East Asians, including patients of Japanese, Korean or Chinese, and Asian Indian origins. More than 50% of the Japanese patients who are diagnosed with neovascular age-related macular degeneration actually have PCV.1 Most PCV lesions are located within the macula (peripapillary lesions are rare),2 and their greatest linear dimension usually is less than 7000 μm. Full-Text PDF" @default.
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• W2026833193 date "2010-09-01" @default.
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• W2026833193 title "Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy" @default.
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• W2026833193 doi "https://doi.org/10.1016/j.ajo.2010.05.033" @default.
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