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- W2026834886 abstract "The cyclic AMP sensor, EPAC1, activates AP1-mediated transcription in HUVECs. Correspondingly, induction of the SOCS3 minimal promoter by EPAC1 requires a single AP1 site that constitutively binds phosphorylated (Ser63) c-Jun in DNA-pull-down assays. c-Jun (Ser63) becomes further phosphorylated following cyclic AMP stimulation and specific activation of protein kinase A (PKA), but not through selective activation of EPAC1. Moreover, despite a requirement for c-Jun for SOCS3 induction in fibroblasts, phospho-null c-Jun (Ser63/73Ala) had little effect on SOCS3 induction by cyclic AMP in HUVECs. AP1 activation and SOCS3 induction by EPAC1 in HUVECs therefore occur independently of c-Jun phosphorylation on Ser63." @default.
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- W2026834886 date "2014-03-11" @default.
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- W2026834886 title "The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs" @default.
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- W2026834886 doi "https://doi.org/10.1016/j.febslet.2014.02.038" @default.
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