Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026841067> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2026841067 endingPage "213" @default.
- W2026841067 startingPage "207" @default.
- W2026841067 abstract "The two major metabolites of ibuprofen, 2-[4-(2-carboxypropyl)phenyl]propionic acid and 2-[4-(2-methyl-2-hydroxypropyl)phenyl]propionic acid, were labelled with tritium. The hydroxy-metabolite containing tritium at α- and β-carbons of the propionic acid moiety was prepared by catalytic reduction of the olefinic double bond in 2-[4-(2-methyl-2-hydroxypropyl)phenyl]propionic acid with tritium-enriched hydrogen. Tritium-labelling at the two carbon atoms α to the two carboxyl groups of the carboxy-metabolite was achieved by initially exchanging the carboxyl hydrogens of the corresponding dimalonic acid derivative synthesised in this work, followed by its decarboxylation. In this process one of the carboxyl groups of each of the malonic acid components is lost as carbon dioxide, transferring its tritium/hydrogen atom to the α-carbon. Copyright © 1999 John Wiley & Sons, Ltd." @default.
- W2026841067 created "2016-06-24" @default.
- W2026841067 creator A5042041773 @default.
- W2026841067 creator A5079028463 @default.
- W2026841067 date "1999-03-01" @default.
- W2026841067 modified "2023-10-10" @default.
- W2026841067 title "Synthesis of tritium-labelled metabolites of ibuprofen" @default.
- W2026841067 doi "https://doi.org/10.1002/(sici)1099-1344(199903)42:3<207::aid-jlcr210>3.0.co;2-5" @default.
- W2026841067 hasPublicationYear "1999" @default.
- W2026841067 type Work @default.
- W2026841067 sameAs 2026841067 @default.
- W2026841067 citedByCount "4" @default.
- W2026841067 countsByYear W20268410672015 @default.
- W2026841067 crossrefType "journal-article" @default.
- W2026841067 hasAuthorship W2026841067A5042041773 @default.
- W2026841067 hasAuthorship W2026841067A5079028463 @default.
- W2026841067 hasConcept C104779481 @default.
- W2026841067 hasConcept C121332964 @default.
- W2026841067 hasConcept C140205800 @default.
- W2026841067 hasConcept C155647269 @default.
- W2026841067 hasConcept C159985019 @default.
- W2026841067 hasConcept C161790260 @default.
- W2026841067 hasConcept C178790620 @default.
- W2026841067 hasConcept C185544564 @default.
- W2026841067 hasConcept C185592680 @default.
- W2026841067 hasConcept C192562407 @default.
- W2026841067 hasConcept C196284684 @default.
- W2026841067 hasConcept C2776568683 @default.
- W2026841067 hasConcept C2776596982 @default.
- W2026841067 hasConcept C2777477808 @default.
- W2026841067 hasConcept C2780595602 @default.
- W2026841067 hasConcept C512968161 @default.
- W2026841067 hasConcept C55493867 @default.
- W2026841067 hasConcept C62520636 @default.
- W2026841067 hasConcept C62538594 @default.
- W2026841067 hasConcept C98345119 @default.
- W2026841067 hasConceptScore W2026841067C104779481 @default.
- W2026841067 hasConceptScore W2026841067C121332964 @default.
- W2026841067 hasConceptScore W2026841067C140205800 @default.
- W2026841067 hasConceptScore W2026841067C155647269 @default.
- W2026841067 hasConceptScore W2026841067C159985019 @default.
- W2026841067 hasConceptScore W2026841067C161790260 @default.
- W2026841067 hasConceptScore W2026841067C178790620 @default.
- W2026841067 hasConceptScore W2026841067C185544564 @default.
- W2026841067 hasConceptScore W2026841067C185592680 @default.
- W2026841067 hasConceptScore W2026841067C192562407 @default.
- W2026841067 hasConceptScore W2026841067C196284684 @default.
- W2026841067 hasConceptScore W2026841067C2776568683 @default.
- W2026841067 hasConceptScore W2026841067C2776596982 @default.
- W2026841067 hasConceptScore W2026841067C2777477808 @default.
- W2026841067 hasConceptScore W2026841067C2780595602 @default.
- W2026841067 hasConceptScore W2026841067C512968161 @default.
- W2026841067 hasConceptScore W2026841067C55493867 @default.
- W2026841067 hasConceptScore W2026841067C62520636 @default.
- W2026841067 hasConceptScore W2026841067C62538594 @default.
- W2026841067 hasConceptScore W2026841067C98345119 @default.
- W2026841067 hasIssue "3" @default.
- W2026841067 hasLocation W20268410671 @default.
- W2026841067 hasOpenAccess W2026841067 @default.
- W2026841067 hasPrimaryLocation W20268410671 @default.
- W2026841067 hasRelatedWork W2006939043 @default.
- W2026841067 hasRelatedWork W2022036454 @default.
- W2026841067 hasRelatedWork W2032779978 @default.
- W2026841067 hasRelatedWork W2052560692 @default.
- W2026841067 hasRelatedWork W2090545846 @default.
- W2026841067 hasRelatedWork W2129869943 @default.
- W2026841067 hasRelatedWork W2381948618 @default.
- W2026841067 hasRelatedWork W2770592384 @default.
- W2026841067 hasRelatedWork W290415106 @default.
- W2026841067 hasRelatedWork W85695970 @default.
- W2026841067 hasVolume "42" @default.
- W2026841067 isParatext "false" @default.
- W2026841067 isRetracted "false" @default.
- W2026841067 magId "2026841067" @default.
- W2026841067 workType "article" @default.