FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026841105> ?p ?o ?g. }

• W2026841105 endingPage "103" @default.
• W2026841105 startingPage "98" @default.
• W2026841105 abstract "What is known and objective Rifampicin is a potent inducer of P-glycoprotein (P-gp) and inhibitor of organic anion-transporting polypeptides (OATPs), with fexofenadine acting as a substrate for both mechanisms. Simultaneous administration of single- or multiple-dose rifampicin 600 mg significantly increases the concentrations of fexofenadine enantiomers by inhibiting OATP transporters. However, the effects of rifampicin 450 mg are unknown. Here, we evaluated the effects of multiple doses of rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in healthy Japanese volunteers. Methods In this randomized, two-phase, double-blind crossover study, 10 healthy volunteers received rifampicin 450 mg/day or placebo for 7 days. On day 7, fexofenadine 60 mg was co-administered simultaneously. Results and discussion Rifampicin significantly increased the mean area under the plasma concentration–time curve (AUC) of (R)- and (S)-fexofenadine (3·10-fold and 3·48-fold, respectively) and decreased the renal clearance of (R)- and (S)-fexofenadine (0·40-fold and 0·47-fold, respectively), causing marked differences in the mean amounts of these enantiomers excreted into the urine in the rifampicin phase (P < 0·001). These results indicated that multiple doses of rifampicin 450 mg may be sufficient to inhibit the renal influx transporter and OATP-mediated hepatic uptake of both enantiomers. Moreover, these effects may be greater than the P-gp-inductive effects of rifampicin. Therefore, the interactive mechanism of multidose rifampicin may occur through a combination of OATP and P-gp transporters, thereby altering the pharmacokinetics of fexofenadine enantiomers. What is new and conclusions In this study of rifampicin 450 mg, the interactive magnitude of the mean AUC values of fexofenadine enantiomers was higher than that observed in the previous study of rifampicin 600 mg, and no dose-dependent inhibitory effects of rifampicin were observed. These effects may be clinically significant in patients receiving fexofenadine and rifampicin." @default.
• W2026841105 created "2016-06-24" @default.
• W2026841105 creator A5022489972 @default.
• W2026841105 creator A5041929394 @default.
• W2026841105 creator A5062272410 @default.
• W2026841105 creator A5086680208 @default.
• W2026841105 creator A5088581964 @default.
• W2026841105 date "2014-09-27" @default.
• W2026841105 modified "2023-09-26" @default.
• W2026841105 title "Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers" @default.
• W2026841105 cites W1510298788 @default.
• W2026841105 cites W1565580371 @default.
• W2026841105 cites W1584857420 @default.
• W2026841105 cites W1783939843 @default.
• W2026841105 cites W1970369624 @default.
• W2026841105 cites W1978116407 @default.
• W2026841105 cites W1982950748 @default.
• W2026841105 cites W1990315223 @default.
• W2026841105 cites W1993198959 @default.
• W2026841105 cites W1998312618 @default.
• W2026841105 cites W1999505152 @default.
• W2026841105 cites W2005966874 @default.
• W2026841105 cites W2008478791 @default.
• W2026841105 cites W2017940034 @default.
• W2026841105 cites W2024762392 @default.
• W2026841105 cites W2026125378 @default.
• W2026841105 cites W2026524951 @default.
• W2026841105 cites W2030021013 @default.
• W2026841105 cites W2041007069 @default.
• W2026841105 cites W2045567622 @default.
• W2026841105 cites W2049869379 @default.
• W2026841105 cites W2050402229 @default.
• W2026841105 cites W2061222476 @default.
• W2026841105 cites W2070243063 @default.
• W2026841105 cites W2073520676 @default.
• W2026841105 cites W2076194172 @default.
• W2026841105 cites W2085335377 @default.
• W2026841105 cites W2101010263 @default.
• W2026841105 cites W2110515871 @default.
• W2026841105 cites W2125542198 @default.
• W2026841105 cites W2131138924 @default.
• W2026841105 cites W2136918221 @default.
• W2026841105 cites W2155775136 @default.
• W2026841105 cites W2158291672 @default.
• W2026841105 cites W2320564129 @default.
• W2026841105 cites W2326010624 @default.
• W2026841105 doi "https://doi.org/10.1111/jcpt.12213" @default.
• W2026841105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25263393" @default.
• W2026841105 hasPublicationYear "2014" @default.
• W2026841105 type Work @default.
• W2026841105 sameAs 2026841105 @default.
• W2026841105 citedByCount "8" @default.
• W2026841105 countsByYear W20268411052015 @default.
• W2026841105 countsByYear W20268411052016 @default.
• W2026841105 countsByYear W20268411052017 @default.
• W2026841105 countsByYear W20268411052019 @default.
• W2026841105 countsByYear W20268411052020 @default.
• W2026841105 crossrefType "journal-article" @default.
• W2026841105 hasAuthorship W2026841105A5022489972 @default.
• W2026841105 hasAuthorship W2026841105A5041929394 @default.
• W2026841105 hasAuthorship W2026841105A5062272410 @default.
• W2026841105 hasAuthorship W2026841105A5086680208 @default.
• W2026841105 hasAuthorship W2026841105A5088581964 @default.
• W2026841105 hasBestOaLocation W20268411051 @default.
• W2026841105 hasConcept C104317684 @default.
• W2026841105 hasConcept C112705442 @default.
• W2026841105 hasConcept C142724271 @default.
• W2026841105 hasConcept C149011108 @default.
• W2026841105 hasConcept C185592680 @default.
• W2026841105 hasConcept C204787440 @default.
• W2026841105 hasConcept C27081682 @default.
• W2026841105 hasConcept C2776678969 @default.
• W2026841105 hasConcept C2776711289 @default.
• W2026841105 hasConcept C2778607973 @default.
• W2026841105 hasConcept C2779303165 @default.
• W2026841105 hasConcept C501593827 @default.
• W2026841105 hasConcept C55493867 @default.
• W2026841105 hasConcept C71924100 @default.
• W2026841105 hasConcept C87813604 @default.
• W2026841105 hasConcept C97320921 @default.
• W2026841105 hasConcept C98274493 @default.
• W2026841105 hasConceptScore W2026841105C104317684 @default.
• W2026841105 hasConceptScore W2026841105C112705442 @default.
• W2026841105 hasConceptScore W2026841105C142724271 @default.
• W2026841105 hasConceptScore W2026841105C149011108 @default.
• W2026841105 hasConceptScore W2026841105C185592680 @default.
• W2026841105 hasConceptScore W2026841105C204787440 @default.
• W2026841105 hasConceptScore W2026841105C27081682 @default.
• W2026841105 hasConceptScore W2026841105C2776678969 @default.
• W2026841105 hasConceptScore W2026841105C2776711289 @default.
• W2026841105 hasConceptScore W2026841105C2778607973 @default.
• W2026841105 hasConceptScore W2026841105C2779303165 @default.
• W2026841105 hasConceptScore W2026841105C501593827 @default.
• W2026841105 hasConceptScore W2026841105C55493867 @default.
• W2026841105 hasConceptScore W2026841105C71924100 @default.
• W2026841105 hasConceptScore W2026841105C87813604 @default.
• W2026841105 hasConceptScore W2026841105C97320921 @default.
• W2026841105 hasConceptScore W2026841105C98274493 @default.

• next