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• W2026845303 endingPage "1140" @default.
• W2026845303 startingPage "1131" @default.
• W2026845303 abstract "Abstract Cysteine cathepsins play a fundamental role in tumor growth, invasion and migration, angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array of human tumors has been well documented. Cysteine cathepsins seem to have a characteristic location-function relationship that leads to non-traditional roles such as those in development and pathology. For example, during tumor development, some cysteine cathepsins are found not just within lysosomes, but are also redistributed into presumptive exocytic vesicles at the cell periphery, resulting in their secretion. This altered localization contributes to non-lysosomal functions that have been linked to malignant progression. Mechanisms for altered localization are not well understood, but do include the interaction of cysteine cathepsins with binding partners that modulate intracellular trafficking and association with specific regions on the cell surface." @default.
• W2026845303 created "2016-06-24" @default.
• W2026845303 creator A5017341322 @default.
• W2026845303 creator A5059642830 @default.
• W2026845303 date "2007-11-01" @default.
• W2026845303 modified "2023-09-27" @default.
• W2026845303 title "Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function" @default.
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