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- W2026854310 abstract "According to recent submicroscopic, cytokinetics, and functional (particularly cytoimmunologic) investigations, no relationship exists between resting microglia (the small argyrophilic cells appearing in undamaged brain tissue, first described by Rio Hortega) and reactive microglia (the argyrophilic cells appearing under pathologic conditions). While resting microglia are apparently cells of neuro-ectodermal origin, all observations tend to indicate that reactive microglia are derived from extravasated blood monocytes and should be called brain macrophages. In the intact brain parenchyma, no macrophages are demonstrable. Free subarachnoidal cells in the cerebrospinal fluid (CSF), perivascular cells, and epiplexus and/or supraependymal cells in the CSF-containing spaces of the normal central nervous system are cells of the mononuclear phagocyte system and must be considered as CSF macrophages. According to rough estimates, the normal adult central nervous system contains a maximum of 280,000 CSF macrophages." @default.
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- W2026854310 date "1982-01-01" @default.
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- W2026854310 title "Are Resting and/or Reactive Microglia Macrophages?" @default.
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- W2026854310 doi "https://doi.org/10.1016/s0171-2985(82)80080-6" @default.
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