Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026854589> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2026854589 endingPage "137" @default.
- W2026854589 startingPage "128" @default.
- W2026854589 abstract "Two Ca2+-dependent endopeptidases endowed with specificities for paired basic residues have been disclosed in rat and ox neurohypophysial secretory granules. Specificities investigated by using synthetic fluorogenic substrates showed the presence of a Lys-Arg endopeptidase with optimum pH close to the granule pH (5.5) and of an Arg-Arg endopeptidase more active at pH 7.0. Granule extracts have virtually no activity towards Lys-Lys-containing susbtrate or monobasic substrates. Pro-Gly-Lys-Arg-chloromethylketone appears a very efficient inhibitor for the Lys-Arg enzyme. Soluble and membrane-bound forms of both endopeptidases have been detected. pH-dependence of membrane binding and partitioning into Triton X-114 suggest that the membrane-bound form of Lys-Arg endopeptidase is associated through an amphiphilic α-helix. It is proposed that the enzyme Lys-Arg cleaves prooxytocin and provasopressin at their signal sequence Gly-Lys-Arg when these precursors arrive in the neurosecretory granules. The processing proceeds in the granules through carboxypeptidase E and α-amidating enzyme complex for giving mature pharmacologically active nonapeptide hormones." @default.
- W2026854589 created "2016-06-24" @default.
- W2026854589 creator A5033640333 @default.
- W2026854589 creator A5035855064 @default.
- W2026854589 creator A5038099252 @default.
- W2026854589 creator A5043141026 @default.
- W2026854589 date "1992-02-01" @default.
- W2026854589 modified "2023-10-14" @default.
- W2026854589 title "Evidence for distinct dibasic processing endopeptidases with Lys-Arg and Arg-Arg specificities in neurohypophysial secretory granules" @default.
- W2026854589 cites W109599291 @default.
- W2026854589 cites W146759131 @default.
- W2026854589 cites W1495099697 @default.
- W2026854589 cites W1501424340 @default.
- W2026854589 cites W1570766778 @default.
- W2026854589 cites W1660651845 @default.
- W2026854589 cites W1949772429 @default.
- W2026854589 cites W1975096426 @default.
- W2026854589 cites W2005785807 @default.
- W2026854589 cites W2007995076 @default.
- W2026854589 cites W2025051667 @default.
- W2026854589 cites W2033118905 @default.
- W2026854589 cites W2081092314 @default.
- W2026854589 cites W2099336487 @default.
- W2026854589 cites W2138006485 @default.
- W2026854589 cites W2156602181 @default.
- W2026854589 doi "https://doi.org/10.1016/0006-291x(92)91618-z" @default.
- W2026854589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1543484" @default.
- W2026854589 hasPublicationYear "1992" @default.
- W2026854589 type Work @default.
- W2026854589 sameAs 2026854589 @default.
- W2026854589 citedByCount "11" @default.
- W2026854589 crossrefType "journal-article" @default.
- W2026854589 hasAuthorship W2026854589A5033640333 @default.
- W2026854589 hasAuthorship W2026854589A5035855064 @default.
- W2026854589 hasAuthorship W2026854589A5038099252 @default.
- W2026854589 hasAuthorship W2026854589A5043141026 @default.
- W2026854589 hasConcept C104826730 @default.
- W2026854589 hasConcept C108477463 @default.
- W2026854589 hasConcept C122191521 @default.
- W2026854589 hasConcept C134337899 @default.
- W2026854589 hasConcept C151730666 @default.
- W2026854589 hasConcept C181199279 @default.
- W2026854589 hasConcept C185592680 @default.
- W2026854589 hasConcept C188027245 @default.
- W2026854589 hasConcept C2777774944 @default.
- W2026854589 hasConcept C49760210 @default.
- W2026854589 hasConcept C55493867 @default.
- W2026854589 hasConcept C86803240 @default.
- W2026854589 hasConceptScore W2026854589C104826730 @default.
- W2026854589 hasConceptScore W2026854589C108477463 @default.
- W2026854589 hasConceptScore W2026854589C122191521 @default.
- W2026854589 hasConceptScore W2026854589C134337899 @default.
- W2026854589 hasConceptScore W2026854589C151730666 @default.
- W2026854589 hasConceptScore W2026854589C181199279 @default.
- W2026854589 hasConceptScore W2026854589C185592680 @default.
- W2026854589 hasConceptScore W2026854589C188027245 @default.
- W2026854589 hasConceptScore W2026854589C2777774944 @default.
- W2026854589 hasConceptScore W2026854589C49760210 @default.
- W2026854589 hasConceptScore W2026854589C55493867 @default.
- W2026854589 hasConceptScore W2026854589C86803240 @default.
- W2026854589 hasIssue "1" @default.
- W2026854589 hasLocation W20268545891 @default.
- W2026854589 hasLocation W20268545892 @default.
- W2026854589 hasOpenAccess W2026854589 @default.
- W2026854589 hasPrimaryLocation W20268545891 @default.
- W2026854589 hasRelatedWork W1609981460 @default.
- W2026854589 hasRelatedWork W1986347639 @default.
- W2026854589 hasRelatedWork W1988423298 @default.
- W2026854589 hasRelatedWork W1991636608 @default.
- W2026854589 hasRelatedWork W2026854589 @default.
- W2026854589 hasRelatedWork W2076070160 @default.
- W2026854589 hasRelatedWork W2080509753 @default.
- W2026854589 hasRelatedWork W3012601050 @default.
- W2026854589 hasRelatedWork W4246626510 @default.
- W2026854589 hasRelatedWork W4252172762 @default.
- W2026854589 hasVolume "183" @default.
- W2026854589 isParatext "false" @default.
- W2026854589 isRetracted "false" @default.
- W2026854589 magId "2026854589" @default.
- W2026854589 workType "article" @default.