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• W2026856784 abstract "Dehydrogenase (cortisol to cortisone) and oxoreductase (cortisone to cortisol) activities of porcine placental 11β-hydroxysteroid dehydrogenase (11β-HSD) were measured in tissue fragment cultures on day 75 of gestation. Dehydrogenase activity was over fivefold greater than oxoreductase activity (p < .001). There were positive linear associations (p < .01) between net dehydrogenase activity (dehydrogenase minus oxoreductase) and fetal weight, fetal length, and placental weight. These data indicate a predominance of placental 11β-HSD dehydrogenase activity at this gestational stage that would insure a net conversion of cortisol to cortisone as it traverses the placenta. The data further suggest that 11β-HSD activities may provide an optimal glucocorticoid environment that is supportive of enhanced fetal and placental growth." @default.
• W2026856784 created "2016-06-24" @default.
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• W2026856784 date "2000-02-01" @default.
• W2026856784 modified "2023-10-15" @default.
• W2026856784 title "Dehydrogenase and oxoreductase activities of porcine placental 11β-hydroxysteroid dehydrogenase" @default.
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• W2026856784 doi "https://doi.org/10.1016/s0024-3205(99)00669-4" @default.
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