Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026861019> ?p ?o ?g. }
- W2026861019 endingPage "2194" @default.
- W2026861019 startingPage "2184" @default.
- W2026861019 abstract "The T cell stimulatory activity of peptides is known to be associated with the cell surface stability and lifetime of the peptide-MHC (pepMHC) complex. In this report, soluble high-affinity T cell receptors (TCRs) that are specific for pepMHC complexes recognized by the mouse CD8+ clone 2C were used to monitor the cell surface lifetimes of synthetic agonist peptides. In the 2C system, Ld-binding peptide p2Ca (LSPFPFDL) has up to 10,000-fold lower activity than peptide QL9 (QLSPFPFDL) even though the 2C TCR binds to p2Ca–Ld and QL9–Ld complexes with similar affinities. Unexpectedly, p2Ca–Ld complexes were found to have a longer cell surface lifetime than QL9–Ld complexes. However, the strong agonist activity of QL9 correlated with its ability to participate in efficient intracellular delivery followed by cell surface expression of the peptide, resulting in high and persistent surface levels of QL9–Ld. The ability of target cells to take up and present QL9 was observed with TAP-deficient cells and TAP-positive cells, including dendritic cells. The process was brefeldin A-sensitive, indicating a requirement for transport of the pepMHC through the ER and/or golgi. Thus, strong T cell stimulatory activity of some pepMHC complexes can be accomplished not only through long cell surface lifetimes of the ligand, but through a mechanism that leads to delayed presentation of the exogenous antigen after intracellular uptake." @default.
- W2026861019 created "2016-06-24" @default.
- W2026861019 creator A5012750709 @default.
- W2026861019 creator A5037320538 @default.
- W2026861019 creator A5069353340 @default.
- W2026861019 creator A5088135588 @default.
- W2026861019 date "2007-03-01" @default.
- W2026861019 modified "2023-10-14" @default.
- W2026861019 title "Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity" @default.
- W2026861019 cites W1512916041 @default.
- W2026861019 cites W1525871963 @default.
- W2026861019 cites W1536244885 @default.
- W2026861019 cites W1541379626 @default.
- W2026861019 cites W1568419891 @default.
- W2026861019 cites W1596782482 @default.
- W2026861019 cites W1893784195 @default.
- W2026861019 cites W1941694730 @default.
- W2026861019 cites W1964934179 @default.
- W2026861019 cites W1975213486 @default.
- W2026861019 cites W1976112622 @default.
- W2026861019 cites W1977812921 @default.
- W2026861019 cites W1984678830 @default.
- W2026861019 cites W1991578992 @default.
- W2026861019 cites W1992253391 @default.
- W2026861019 cites W1993607703 @default.
- W2026861019 cites W1996123391 @default.
- W2026861019 cites W1996832497 @default.
- W2026861019 cites W1997131546 @default.
- W2026861019 cites W1998048927 @default.
- W2026861019 cites W2001656273 @default.
- W2026861019 cites W2007211891 @default.
- W2026861019 cites W2010014769 @default.
- W2026861019 cites W2013555955 @default.
- W2026861019 cites W2017816736 @default.
- W2026861019 cites W2019993505 @default.
- W2026861019 cites W2042411369 @default.
- W2026861019 cites W2044009370 @default.
- W2026861019 cites W2047224828 @default.
- W2026861019 cites W2047747639 @default.
- W2026861019 cites W2049394859 @default.
- W2026861019 cites W2052383501 @default.
- W2026861019 cites W2064056403 @default.
- W2026861019 cites W2064773757 @default.
- W2026861019 cites W2065042783 @default.
- W2026861019 cites W2068872497 @default.
- W2026861019 cites W2079847375 @default.
- W2026861019 cites W2088127446 @default.
- W2026861019 cites W2089010131 @default.
- W2026861019 cites W2089666002 @default.
- W2026861019 cites W2094213517 @default.
- W2026861019 cites W2110365405 @default.
- W2026861019 cites W2112997727 @default.
- W2026861019 cites W2115603980 @default.
- W2026861019 cites W2127888216 @default.
- W2026861019 cites W2133696052 @default.
- W2026861019 cites W2139229993 @default.
- W2026861019 cites W2140018744 @default.
- W2026861019 cites W2140844094 @default.
- W2026861019 cites W2150632173 @default.
- W2026861019 cites W2152830055 @default.
- W2026861019 cites W2154971211 @default.
- W2026861019 cites W2161596564 @default.
- W2026861019 cites W2166676682 @default.
- W2026861019 cites W2168400876 @default.
- W2026861019 doi "https://doi.org/10.1016/j.molimm.2006.11.016" @default.
- W2026861019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2547883" @default.
- W2026861019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17169430" @default.
- W2026861019 hasPublicationYear "2007" @default.
- W2026861019 type Work @default.
- W2026861019 sameAs 2026861019 @default.
- W2026861019 citedByCount "12" @default.
- W2026861019 countsByYear W20268610192012 @default.
- W2026861019 countsByYear W20268610192013 @default.
- W2026861019 countsByYear W20268610192019 @default.
- W2026861019 crossrefType "journal-article" @default.
- W2026861019 hasAuthorship W2026861019A5012750709 @default.
- W2026861019 hasAuthorship W2026861019A5037320538 @default.
- W2026861019 hasAuthorship W2026861019A5069353340 @default.
- W2026861019 hasAuthorship W2026861019A5088135588 @default.
- W2026861019 hasBestOaLocation W20268610192 @default.
- W2026861019 hasConcept C119062480 @default.
- W2026861019 hasConcept C147483822 @default.
- W2026861019 hasConcept C1491633281 @default.
- W2026861019 hasConcept C154317977 @default.
- W2026861019 hasConcept C167672396 @default.
- W2026861019 hasConcept C170493617 @default.
- W2026861019 hasConcept C170627219 @default.
- W2026861019 hasConcept C185592680 @default.
- W2026861019 hasConcept C19317047 @default.
- W2026861019 hasConcept C202751555 @default.
- W2026861019 hasConcept C203014093 @default.
- W2026861019 hasConcept C2776090121 @default.
- W2026861019 hasConcept C2778938600 @default.
- W2026861019 hasConcept C2779281246 @default.
- W2026861019 hasConcept C2781373781 @default.
- W2026861019 hasConcept C552990157 @default.
- W2026861019 hasConcept C55493867 @default.
- W2026861019 hasConcept C79879829 @default.