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• W2026865013 endingPage "53" @default.
• W2026865013 startingPage "25" @default.
• W2026865013 abstract "The heart is the first embryonic organ to function. Early in development, the heart shows autorhythmycity and peristaltoid contraction waves [1, 2]. Contraction requires the expression of a specific set of proteins that form the contractile apparatus, i.e. the sarcomere. The contraction–relaxation cycle of the sarcomeric apparatus is mediated by changing local concentrations of free calcium. This function is achieved by another set of specific proteins, located in the sarcoplasmic reticulum and in the sarcolemma.Fascinating questions that are still poorly understood are how the cardiogenic lineage becomes established to form the peristaltoid contracting tube without valves and how this tube becomes transformed into the synchronous-contracting four-chambered heart with unidirectional valves. It is well documented that the expression of the different isoforms of contractile proteins changes considerably during these stages (for a review see [3]). However, a detailed analysis of the changes in the patterns of gene expression in relation to cardiac morphogenesis is lacking. In the present review we try to fill this gap. We have centred our attention on gene products (mRNA and protein) expressed in the working myocardium of mammals and birds. No distinction has been made when mRNA and protein display the same pattern of expression, however we have highlighted those cases where the pattern of expression differs between mRNA and protein. The development and expression pattern of genes of the conduction system of the heart merits an independent review [4](Moorman et al., Circ. Res., in press). Data referring to other experimental models as Drosophila , Xenopus or zebrafish ( Danio rerio ) are included only if they are helpful for our general understanding. Often only gene expression in the presumptive atria and/or presumptive ventricles is mentioned, whereas understanding the functional significance of the patterns of gene expression requires knowledge of the entire pattern including the … * Corresponding author. Tel.: +31 (20) 5664928; fax: +31 (20) 6976177; e-mail: a.f.moorman@amc.uva.nl" @default.
• W2026865013 created "2016-06-24" @default.
• W2026865013 creator A5002005916 @default.
• W2026865013 creator A5052827329 @default.
• W2026865013 creator A5081010221 @default.
• W2026865013 date "1998-04-01" @default.
• W2026865013 modified "2023-09-23" @default.
• W2026865013 title "Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model" @default.
• W2026865013 cites W104685696 @default.
• W2026865013 cites W105678245 @default.
• W2026865013 cites W112230570 @default.
• W2026865013 cites W1241436880 @default.
• W2026865013 cites W1492839186 @default.
• W2026865013 cites W1493851469 @default.
• W2026865013 cites W1499775870 @default.
• W2026865013 cites W1501827434 @default.
• W2026865013 cites W1511737308 @default.
• W2026865013 cites W1513222164 @default.
• W2026865013 cites W1520012696 @default.
• W2026865013 cites W1520989958 @default.
• W2026865013 cites W1524149821 @default.
• W2026865013 cites W1525891657 @default.
• W2026865013 cites W1531986635 @default.
• W2026865013 cites W1539005426 @default.
• W2026865013 cites W1555620308 @default.
• W2026865013 cites W1557719847 @default.
• W2026865013 cites W1568842777 @default.
• W2026865013 cites W1574806752 @default.
• W2026865013 cites W1577509897 @default.
• W2026865013 cites W1582533342 @default.
• W2026865013 cites W1590009622 @default.
• W2026865013 cites W1596115288 @default.
• W2026865013 cites W1597808722 @default.
• W2026865013 cites W1598771652 @default.
• W2026865013 cites W1605519274 @default.
• W2026865013 cites W1609528353 @default.
• W2026865013 cites W1681826624 @default.
• W2026865013 cites W1834902511 @default.
• W2026865013 cites W1835642409 @default.
• W2026865013 cites W1849676176 @default.
• W2026865013 cites W1872338654 @default.
• W2026865013 cites W1880935934 @default.
• W2026865013 cites W1906832763 @default.
• W2026865013 cites W1931621770 @default.
• W2026865013 cites W1953411904 @default.
• W2026865013 cites W1960160851 @default.
• W2026865013 cites W1964375423 @default.
• W2026865013 cites W1965509658 @default.
• W2026865013 cites W1967529494 @default.
• W2026865013 cites W1969447878 @default.
• W2026865013 cites W1969891023 @default.
• W2026865013 cites W1970004542 @default.
• W2026865013 cites W1971977081 @default.
• W2026865013 cites W1972613882 @default.
• W2026865013 cites W1974164855 @default.
• W2026865013 cites W1974596653 @default.
• W2026865013 cites W1974703394 @default.
• W2026865013 cites W1979163680 @default.
• W2026865013 cites W1979405033 @default.
• W2026865013 cites W1980141913 @default.
• W2026865013 cites W1982210988 @default.
• W2026865013 cites W1982424110 @default.
• W2026865013 cites W1983089518 @default.
• W2026865013 cites W1983637156 @default.
• W2026865013 cites W1984554418 @default.
• W2026865013 cites W1986309977 @default.
• W2026865013 cites W1986639792 @default.
• W2026865013 cites W1986819632 @default.
• W2026865013 cites W1986930981 @default.
• W2026865013 cites W1987901968 @default.
• W2026865013 cites W1988445456 @default.
• W2026865013 cites W1989077450 @default.
• W2026865013 cites W1989640224 @default.
• W2026865013 cites W1990511686 @default.
• W2026865013 cites W1991690216 @default.
• W2026865013 cites W1991703781 @default.
• W2026865013 cites W1992023637 @default.
• W2026865013 cites W1993423515 @default.
• W2026865013 cites W1993862102 @default.
• W2026865013 cites W1994241975 @default.
• W2026865013 cites W1995640088 @default.
• W2026865013 cites W1997303582 @default.
• W2026865013 cites W1997971733 @default.
• W2026865013 cites W1998340594 @default.
• W2026865013 cites W1999758837 @default.
• W2026865013 cites W2000093536 @default.
• W2026865013 cites W2000141012 @default.
• W2026865013 cites W2000676318 @default.
• W2026865013 cites W2001260034 @default.
• W2026865013 cites W2001475413 @default.
• W2026865013 cites W2004537703 @default.
• W2026865013 cites W2004983957 @default.
• W2026865013 cites W2006852013 @default.
• W2026865013 cites W2010332455 @default.
• W2026865013 cites W2010494450 @default.
• W2026865013 cites W2012463306 @default.
• W2026865013 cites W2012563752 @default.
• W2026865013 cites W2013741570 @default.

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