FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026871647> ?p ?o ?g. }

• W2026871647 endingPage "2935" @default.
• W2026871647 startingPage "2924" @default.
• W2026871647 abstract "The accurate replication and transmission of genetic information is critical in the life of an organism. During its entire lifespan, the genetic information is constantly under attack from endogenous and exogenous sources of damage. To ensure that the content of its genetic information is faithfully preserved for synthesis and transmission, eukaryotic cells have developed a complex system of genomic quality control. Key players in this process are DNA polymerases, the enzymes responsible for synthesizing the DNA, because errors introduced into the genome by polymerase can result in mutations. We use DNA polymerase beta (pol beta) as a model system to investigate mechanisms of preserving fidelity during nucleotide incorporation. In the study described here, we characterized the role that loop II of pol beta plays in maintaining the activity and fidelity of pol beta. We report here that the absence or shortening of loop II compromises the catalytic activity of pol beta. Our data also show that loop variants of a specific length have a lower fidelity when compared to the wild-type polymerase. Taken together, our results indicate that loop II is important for the catalytic activity and fidelity of pol beta." @default.
• W2026871647 created "2016-06-24" @default.
• W2026871647 creator A5031828516 @default.
• W2026871647 creator A5037218927 @default.
• W2026871647 creator A5052135283 @default.
• W2026871647 date "2007-04-16" @default.
• W2026871647 modified "2023-10-17" @default.
• W2026871647 title "Loop II of DNA polymerase beta is important for polymerization activity and fidelity" @default.
• W2026871647 cites W1517059827 @default.
• W2026871647 cites W1545021361 @default.
• W2026871647 cites W1590831713 @default.
• W2026871647 cites W1927048408 @default.
• W2026871647 cites W1963962795 @default.
• W2026871647 cites W1964673927 @default.
• W2026871647 cites W1968835388 @default.
• W2026871647 cites W1971602039 @default.
• W2026871647 cites W1972821008 @default.
• W2026871647 cites W1983927556 @default.
• W2026871647 cites W1986752150 @default.
• W2026871647 cites W1989755486 @default.
• W2026871647 cites W1990710864 @default.
• W2026871647 cites W1992600590 @default.
• W2026871647 cites W1994530601 @default.
• W2026871647 cites W1999423188 @default.
• W2026871647 cites W2000605935 @default.
• W2026871647 cites W2004066268 @default.
• W2026871647 cites W2004499709 @default.
• W2026871647 cites W2005762143 @default.
• W2026871647 cites W2012091906 @default.
• W2026871647 cites W2016721913 @default.
• W2026871647 cites W2019918748 @default.
• W2026871647 cites W2026830245 @default.
• W2026871647 cites W2030867144 @default.
• W2026871647 cites W2031608406 @default.
• W2026871647 cites W2033002752 @default.
• W2026871647 cites W2035426334 @default.
• W2026871647 cites W2037240454 @default.
• W2026871647 cites W2044064237 @default.
• W2026871647 cites W2050495185 @default.
• W2026871647 cites W2063055181 @default.
• W2026871647 cites W2063716792 @default.
• W2026871647 cites W2072148275 @default.
• W2026871647 cites W2072779476 @default.
• W2026871647 cites W2073403193 @default.
• W2026871647 cites W2074838235 @default.
• W2026871647 cites W2082963155 @default.
• W2026871647 cites W2086294668 @default.
• W2026871647 cites W2097997319 @default.
• W2026871647 cites W2107232477 @default.
• W2026871647 cites W2124632687 @default.
• W2026871647 cites W2130233138 @default.
• W2026871647 cites W2134259738 @default.
• W2026871647 cites W2141280535 @default.
• W2026871647 cites W2149922717 @default.
• W2026871647 cites W2150411863 @default.
• W2026871647 cites W2157114285 @default.
• W2026871647 cites W2158742644 @default.
• W2026871647 cites W2162528126 @default.
• W2026871647 cites W2174994538 @default.
• W2026871647 doi "https://doi.org/10.1093/nar/gkm126" @default.
• W2026871647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1888816" @default.
• W2026871647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17439962" @default.
• W2026871647 hasPublicationYear "2007" @default.
• W2026871647 type Work @default.
• W2026871647 sameAs 2026871647 @default.
• W2026871647 citedByCount "12" @default.
• W2026871647 countsByYear W20268716472012 @default.
• W2026871647 countsByYear W20268716472013 @default.
• W2026871647 countsByYear W20268716472014 @default.
• W2026871647 countsByYear W20268716472019 @default.
• W2026871647 crossrefType "journal-article" @default.
• W2026871647 hasAuthorship W2026871647A5031828516 @default.
• W2026871647 hasAuthorship W2026871647A5037218927 @default.
• W2026871647 hasAuthorship W2026871647A5052135283 @default.
• W2026871647 hasBestOaLocation W20268716471 @default.
• W2026871647 hasConcept C104317684 @default.
• W2026871647 hasConcept C131140672 @default.
• W2026871647 hasConcept C134935766 @default.
• W2026871647 hasConcept C153911025 @default.
• W2026871647 hasConcept C156719811 @default.
• W2026871647 hasConcept C187206112 @default.
• W2026871647 hasConcept C199360897 @default.
• W2026871647 hasConcept C2756471 @default.
• W2026871647 hasConcept C2776174256 @default.
• W2026871647 hasConcept C2778462844 @default.
• W2026871647 hasConcept C41008148 @default.
• W2026871647 hasConcept C49105822 @default.
• W2026871647 hasConcept C54355233 @default.
• W2026871647 hasConcept C552990157 @default.
• W2026871647 hasConcept C70721500 @default.
• W2026871647 hasConcept C73573662 @default.
• W2026871647 hasConcept C76535049 @default.
• W2026871647 hasConcept C82381507 @default.
• W2026871647 hasConcept C86803240 @default.
• W2026871647 hasConcept C88354546 @default.
• W2026871647 hasConceptScore W2026871647C104317684 @default.
• W2026871647 hasConceptScore W2026871647C131140672 @default.
• W2026871647 hasConceptScore W2026871647C134935766 @default.

• next