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- W2026881175 endingPage "e104420" @default.
- W2026881175 startingPage "e104420" @default.
- W2026881175 abstract "The analgesic effect of delta-opioid receptor (DOR) ligands in neuropathic pain is not diminished in contrast to other opioid receptor ligands, which lose their effectiveness as analgesics. In this study, we examine whether this effect is related to nerve injury-induced microglial activation. We therefore investigated the influence of minocycline-induced inhibition of microglial activation on the analgesic effects of opioid receptor agonists: morphine, DAMGO, U50,488H, DPDPE, Deltorphin II and SNC80 after chronic constriction injury (CCI) to the sciatic nerve in rats. Pre-emptive and repeated administration of minocycline (30 mg/kg, i.p.) over 7 days significantly reduced allodynia and hyperalgesia as measured on day 7 after CCI. The antiallodynic and antihyperalgesic effects of intrathecally (i.t.) administered morphine (10-20 µg), DAMGO (1-2 µg) and U50,488H (25-50 µg) were significantly potentiated in rats after minocycline, but no such changes were observed after DPDPE (10-20 µg), deltorphin II (1.5-15 µg) and SNC80 (10-20 µg) administration. Additionally, nerve injury-induced down-regulation of all types of opioid receptors in the spinal cord and dorsal root ganglia was not influenced by minocycline, which indicates that the effects of opioid ligands are dependent on other changes, presumably neuroimmune interactions. Our study of rat primary microglial cell culture using qRT-PCR, Western blotting and immunocytochemistry confirmed the presence of mu-opioid receptors (MOR) and kappa-opioid receptors (KOR), further we provide the first evidence for the lack of DOR on microglial cells. In summary, DOR analgesia is different from analgesia induced by MOR and KOR receptors because it does not dependent on injury-induced microglial activation. DOR agonists appear to be the best candidates for new drugs to treat neuropathic pain." @default.
- W2026881175 created "2016-06-24" @default.
- W2026881175 creator A5003101597 @default.
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- W2026881175 creator A5054954393 @default.
- W2026881175 creator A5068565210 @default.
- W2026881175 creator A5074476887 @default.
- W2026881175 date "2014-08-08" @default.
- W2026881175 modified "2023-10-16" @default.
- W2026881175 title "Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain" @default.
- W2026881175 cites W1543274849 @default.
- W2026881175 cites W1545606956 @default.
- W2026881175 cites W1784442090 @default.
- W2026881175 cites W1841237986 @default.
- W2026881175 cites W1964575045 @default.
- W2026881175 cites W1965572881 @default.
- W2026881175 cites W1969138450 @default.
- W2026881175 cites W1969562369 @default.
- W2026881175 cites W1969763864 @default.
- W2026881175 cites W1971283543 @default.
- W2026881175 cites W1972510628 @default.
- W2026881175 cites W1979859079 @default.
- W2026881175 cites W1984550437 @default.
- W2026881175 cites W1985919021 @default.
- W2026881175 cites W1988602754 @default.
- W2026881175 cites W1989435502 @default.
- W2026881175 cites W1992206444 @default.
- W2026881175 cites W1995471440 @default.
- W2026881175 cites W2000076382 @default.
- W2026881175 cites W2003028048 @default.
- W2026881175 cites W2003438800 @default.
- W2026881175 cites W2004572321 @default.
- W2026881175 cites W2005174659 @default.
- W2026881175 cites W2006050476 @default.
- W2026881175 cites W2008247302 @default.
- W2026881175 cites W2010469304 @default.
- W2026881175 cites W2011661257 @default.
- W2026881175 cites W2011724047 @default.
- W2026881175 cites W2011973300 @default.
- W2026881175 cites W2012310516 @default.
- W2026881175 cites W2012350074 @default.
- W2026881175 cites W2012966353 @default.
- W2026881175 cites W2012974254 @default.
- W2026881175 cites W2016448869 @default.
- W2026881175 cites W2016560481 @default.
- W2026881175 cites W2021793024 @default.
- W2026881175 cites W2024360454 @default.
- W2026881175 cites W2025046733 @default.
- W2026881175 cites W2026601485 @default.
- W2026881175 cites W2027591014 @default.
- W2026881175 cites W2029121478 @default.
- W2026881175 cites W2029190354 @default.
- W2026881175 cites W2030194369 @default.
- W2026881175 cites W2033283481 @default.
- W2026881175 cites W2034756951 @default.
- W2026881175 cites W2035370590 @default.
- W2026881175 cites W2038958959 @default.
- W2026881175 cites W2040725197 @default.
- W2026881175 cites W2041008164 @default.
- W2026881175 cites W2045112376 @default.
- W2026881175 cites W2049141458 @default.
- W2026881175 cites W2053855385 @default.
- W2026881175 cites W2054119130 @default.
- W2026881175 cites W2056959062 @default.
- W2026881175 cites W2057386002 @default.
- W2026881175 cites W2058020736 @default.
- W2026881175 cites W2058713047 @default.
- W2026881175 cites W2059393503 @default.
- W2026881175 cites W2059646315 @default.
- W2026881175 cites W2064241749 @default.
- W2026881175 cites W2065720725 @default.
- W2026881175 cites W2065950517 @default.
- W2026881175 cites W2067356106 @default.
- W2026881175 cites W2067931227 @default.
- W2026881175 cites W2069609049 @default.
- W2026881175 cites W2070312747 @default.
- W2026881175 cites W2071488336 @default.
- W2026881175 cites W2073947022 @default.
- W2026881175 cites W2075525256 @default.
- W2026881175 cites W2077185029 @default.
- W2026881175 cites W2078463677 @default.
- W2026881175 cites W2082534109 @default.
- W2026881175 cites W2086139880 @default.
- W2026881175 cites W2086719493 @default.
- W2026881175 cites W2086990722 @default.
- W2026881175 cites W2087454739 @default.
- W2026881175 cites W2088168096 @default.
- W2026881175 cites W2088752266 @default.
- W2026881175 cites W2090623519 @default.
- W2026881175 cites W2091172151 @default.
- W2026881175 cites W2092501785 @default.
- W2026881175 cites W2095551725 @default.
- W2026881175 cites W2096686163 @default.
- W2026881175 cites W2110648322 @default.
- W2026881175 cites W2111504943 @default.
- W2026881175 cites W2111920109 @default.
- W2026881175 cites W2113617025 @default.