Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026931707> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2026931707 endingPage "60" @default.
- W2026931707 startingPage "55" @default.
- W2026931707 abstract "To document over-expression of protooncogenes in tumors, it is necessary to determine the level of expression in the progenitor normal tissue. These studies compare the levels of nuclear transcription of a series of growth-factor related genes and protooncogenes in human glioblastoma cell lines with those in three normal glial cell populations. The unusual finding was that levels in the three normal glial cell populations varied considerably for several genes and thus overexpression of a specific gene in a tumor cell when compared to just one normal glial cell population would not necessarily represent overexpression. In this study, we compared the level of 17 genes in 7 tumors to the highest level of each gene found in any of three normal glial cell populations. Over-expression of PDGF-B in 47 glioblastoma cell lines, EGFR in 17, neu in 17 IGF-2 in 17 and ros in 27 was observed. The variation observed in the normal glial cell populations emphasizes the possibility that the normal glial cell populations represent different glial cell lineages and/or stages of differentiation and that the tumors could have arisen from different normal glial cells. Matching lineages of normal and tumor cells, probably by monoclonal antibody reactions, may be required to accurately define over-expression." @default.
- W2026931707 created "2016-06-24" @default.
- W2026931707 creator A5026958024 @default.
- W2026931707 creator A5028915531 @default.
- W2026931707 creator A5029714215 @default.
- W2026931707 creator A5048535578 @default.
- W2026931707 date "1992-07-01" @default.
- W2026931707 modified "2023-09-23" @default.
- W2026931707 title "Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells" @default.
- W2026931707 cites W1526030166 @default.
- W2026931707 cites W1942629554 @default.
- W2026931707 cites W1973071934 @default.
- W2026931707 cites W1993914847 @default.
- W2026931707 cites W1998684684 @default.
- W2026931707 cites W2021253208 @default.
- W2026931707 cites W2043487198 @default.
- W2026931707 cites W2055259320 @default.
- W2026931707 cites W2059668898 @default.
- W2026931707 cites W2061820313 @default.
- W2026931707 cites W2072140252 @default.
- W2026931707 cites W2078351568 @default.
- W2026931707 cites W2140375000 @default.
- W2026931707 cites W2142207835 @default.
- W2026931707 cites W2150268629 @default.
- W2026931707 doi "https://doi.org/10.1016/0304-3835(92)90213-f" @default.
- W2026931707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1324785" @default.
- W2026931707 hasPublicationYear "1992" @default.
- W2026931707 type Work @default.
- W2026931707 sameAs 2026931707 @default.
- W2026931707 citedByCount "12" @default.
- W2026931707 crossrefType "journal-article" @default.
- W2026931707 hasAuthorship W2026931707A5026958024 @default.
- W2026931707 hasAuthorship W2026931707A5028915531 @default.
- W2026931707 hasAuthorship W2026931707A5029714215 @default.
- W2026931707 hasAuthorship W2026931707A5048535578 @default.
- W2026931707 hasConcept C104317684 @default.
- W2026931707 hasConcept C144024400 @default.
- W2026931707 hasConcept C1491633281 @default.
- W2026931707 hasConcept C149923435 @default.
- W2026931707 hasConcept C150194340 @default.
- W2026931707 hasConcept C169760540 @default.
- W2026931707 hasConcept C189014844 @default.
- W2026931707 hasConcept C201750760 @default.
- W2026931707 hasConcept C2780884517 @default.
- W2026931707 hasConcept C28328180 @default.
- W2026931707 hasConcept C2908647359 @default.
- W2026931707 hasConcept C529278444 @default.
- W2026931707 hasConcept C54355233 @default.
- W2026931707 hasConcept C62112901 @default.
- W2026931707 hasConcept C81885089 @default.
- W2026931707 hasConcept C86803240 @default.
- W2026931707 hasConcept C95444343 @default.
- W2026931707 hasConceptScore W2026931707C104317684 @default.
- W2026931707 hasConceptScore W2026931707C144024400 @default.
- W2026931707 hasConceptScore W2026931707C1491633281 @default.
- W2026931707 hasConceptScore W2026931707C149923435 @default.
- W2026931707 hasConceptScore W2026931707C150194340 @default.
- W2026931707 hasConceptScore W2026931707C169760540 @default.
- W2026931707 hasConceptScore W2026931707C189014844 @default.
- W2026931707 hasConceptScore W2026931707C201750760 @default.
- W2026931707 hasConceptScore W2026931707C2780884517 @default.
- W2026931707 hasConceptScore W2026931707C28328180 @default.
- W2026931707 hasConceptScore W2026931707C2908647359 @default.
- W2026931707 hasConceptScore W2026931707C529278444 @default.
- W2026931707 hasConceptScore W2026931707C54355233 @default.
- W2026931707 hasConceptScore W2026931707C62112901 @default.
- W2026931707 hasConceptScore W2026931707C81885089 @default.
- W2026931707 hasConceptScore W2026931707C86803240 @default.
- W2026931707 hasConceptScore W2026931707C95444343 @default.
- W2026931707 hasIssue "1" @default.
- W2026931707 hasLocation W20269317071 @default.
- W2026931707 hasLocation W20269317072 @default.
- W2026931707 hasOpenAccess W2026931707 @default.
- W2026931707 hasPrimaryLocation W20269317071 @default.
- W2026931707 hasRelatedWork W133445481 @default.
- W2026931707 hasRelatedWork W2009966535 @default.
- W2026931707 hasRelatedWork W2066519212 @default.
- W2026931707 hasRelatedWork W2083693850 @default.
- W2026931707 hasRelatedWork W2169438904 @default.
- W2026931707 hasRelatedWork W2363880822 @default.
- W2026931707 hasRelatedWork W2374592133 @default.
- W2026931707 hasRelatedWork W2999831276 @default.
- W2026931707 hasRelatedWork W3213450778 @default.
- W2026931707 hasRelatedWork W4307860292 @default.
- W2026931707 hasVolume "65" @default.
- W2026931707 isParatext "false" @default.
- W2026931707 isRetracted "false" @default.
- W2026931707 magId "2026931707" @default.
- W2026931707 workType "article" @default.