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- W2026949173 abstract "Shared candidate gene regions point to a link between autistic disorders and attention-deficit/hyperactivity disorder (ADHD). Although they represent nosologically different diagnoses, the disorders do show some shared symptoms, above all inattention. For both disorders, the association with the serotonergic system is a focus of current research.The current work provides an overview of serotonergic mechanisms in ADHD and autistic disorders as well as the resulting pharmacogenetic approaches.No uniform picture emerges either for ADHD or for autistic disorders. In pharmacogenetic terms, there are some isolated studies on associations between serotonergic mechanisms and pharmacotherapy. For the area of autism, such studies are still lacking.The presented serotonergic mechanisms show relationships of this polymorphism to ADHD and autistic disorders, but they do not result in a uniform picture. The overlaps can best be explained by a dimensional classification approach. As yet, only a small number of studies on attentional disorders in autism and ADHD using shared samples have been carried out. With regard to diagnostics and therapy, analyses on the etiology of the attentional disorder of ADHD and autism are required." @default.
- W2026949173 created "2016-06-24" @default.
- W2026949173 creator A5087305199 @default.
- W2026949173 creator A5089791563 @default.
- W2026949173 date "2007-01-01" @default.
- W2026949173 modified "2023-10-16" @default.
- W2026949173 title "What Do We Know about the Serotonergic Genetic Heterogeneity in Attention-Deficit/Hyperactivity and Autistic Disorders?" @default.
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- W2026949173 doi "https://doi.org/10.1159/000105531" @default.
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