FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026959134> ?p ?o ?g. }

• W2026959134 endingPage "195" @default.
• W2026959134 startingPage "189" @default.
• W2026959134 abstract "Human estrogen receptor α (ERα)-mediated transcription activation was evaluated in the yeast Saccharomyces cerevisiae using both the native ERα and a G400V variant. A previous study [1] demonstrated that coexpression of human SRC-1, a potent stimulator of ERα function in mammalian cells, potentiated ERα-mediated gene expression in yeast over five-fold in an E2-dependent manner. In the present study, two additional human coactivator proteins were shown to potentiate ERα-mediated gene expression in yeast. SRC2 potentiated transactivation two- to three-fold while SRC3 potentiated transactivation five- to eight-fold. Both human coactivators potentiated both the native ERα and the G400V variant in an E2-dependent manner. The effect of a human corepressor protein was also evaluated in yeast. Repressor of estrogen receptor activity (REA) did not affect E2-induced transactivation by ERα (either isoform). However, in a strain that coexpressed human SRC1, REA reduced E2-induced transactivation to that observed with ERα alone. Furthermore, repression of SRC1 potentiation was specific for the native ERα since REA had no effect on SRC1 potentiation of the G400V variant. Additionally, REA repression was specific for SRC1 since potentiation of ERα (either isoform) transactivation by SRC2 and SRC3 was unaffected by coexpression of REA. These results support previous observations in mammalian cells that REA does not prevent ERα from binding to DNA but does inhibit potentiation of ERα-mediated transactivation by SRC1. The results in the present study further characterize REA-mediated repression, and demonstrate the utility of this yeast system for dissecting molecular mechanisms involved in regulating gene transactivation by human ERα." @default.
• W2026959134 created "2016-06-24" @default.
• W2026959134 creator A5042751590 @default.
• W2026959134 date "2007-02-01" @default.
• W2026959134 modified "2023-10-18" @default.
• W2026959134 title "Regulation of human estrogen receptor α-mediated gene transactivation in Saccharomyces cerevisiae by human coactivator and corepressor proteins" @default.
• W2026959134 cites W1493268813 @default.
• W2026959134 cites W1501286679 @default.
• W2026959134 cites W1562107474 @default.
• W2026959134 cites W1562960938 @default.
• W2026959134 cites W1613446635 @default.
• W2026959134 cites W1966475217 @default.
• W2026959134 cites W1973782344 @default.
• W2026959134 cites W1979439941 @default.
• W2026959134 cites W1987183940 @default.
• W2026959134 cites W1993423079 @default.
• W2026959134 cites W1998637238 @default.
• W2026959134 cites W2000456081 @default.
• W2026959134 cites W2002878871 @default.
• W2026959134 cites W2003027153 @default.
• W2026959134 cites W2012155675 @default.
• W2026959134 cites W2016203922 @default.
• W2026959134 cites W2022110250 @default.
• W2026959134 cites W2045389096 @default.
• W2026959134 cites W2052203027 @default.
• W2026959134 cites W2054188881 @default.
• W2026959134 cites W2057755467 @default.
• W2026959134 cites W2060128629 @default.
• W2026959134 cites W2068113812 @default.
• W2026959134 cites W2072508661 @default.
• W2026959134 cites W2074402209 @default.
• W2026959134 cites W2081905101 @default.
• W2026959134 cites W2094230077 @default.
• W2026959134 cites W2097921658 @default.
• W2026959134 cites W2110992142 @default.
• W2026959134 cites W2143241514 @default.
• W2026959134 cites W2144011606 @default.
• W2026959134 cites W2148208243 @default.
• W2026959134 doi "https://doi.org/10.1016/j.jsbmb.2006.11.001" @default.
• W2026959134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17194583" @default.
• W2026959134 hasPublicationYear "2007" @default.
• W2026959134 type Work @default.
• W2026959134 sameAs 2026959134 @default.
• W2026959134 citedByCount "5" @default.
• W2026959134 countsByYear W20269591342015 @default.
• W2026959134 crossrefType "journal-article" @default.
• W2026959134 hasAuthorship W2026959134A5042751590 @default.
• W2026959134 hasConcept C104317684 @default.
• W2026959134 hasConcept C121608353 @default.
• W2026959134 hasConcept C1292079 @default.
• W2026959134 hasConcept C146777309 @default.
• W2026959134 hasConcept C153911025 @default.
• W2026959134 hasConcept C195598365 @default.
• W2026959134 hasConcept C203966977 @default.
• W2026959134 hasConcept C530470458 @default.
• W2026959134 hasConcept C54355233 @default.
• W2026959134 hasConcept C55493867 @default.
• W2026959134 hasConcept C63932345 @default.
• W2026959134 hasConcept C77445288 @default.
• W2026959134 hasConcept C84606932 @default.
• W2026959134 hasConcept C86339819 @default.
• W2026959134 hasConcept C86803240 @default.
• W2026959134 hasConcept C95444343 @default.
• W2026959134 hasConceptScore W2026959134C104317684 @default.
• W2026959134 hasConceptScore W2026959134C121608353 @default.
• W2026959134 hasConceptScore W2026959134C1292079 @default.
• W2026959134 hasConceptScore W2026959134C146777309 @default.
• W2026959134 hasConceptScore W2026959134C153911025 @default.
• W2026959134 hasConceptScore W2026959134C195598365 @default.
• W2026959134 hasConceptScore W2026959134C203966977 @default.
• W2026959134 hasConceptScore W2026959134C530470458 @default.
• W2026959134 hasConceptScore W2026959134C54355233 @default.
• W2026959134 hasConceptScore W2026959134C55493867 @default.
• W2026959134 hasConceptScore W2026959134C63932345 @default.
• W2026959134 hasConceptScore W2026959134C77445288 @default.
• W2026959134 hasConceptScore W2026959134C84606932 @default.
• W2026959134 hasConceptScore W2026959134C86339819 @default.
• W2026959134 hasConceptScore W2026959134C86803240 @default.
• W2026959134 hasConceptScore W2026959134C95444343 @default.
• W2026959134 hasIssue "2" @default.
• W2026959134 hasLocation W20269591341 @default.
• W2026959134 hasLocation W20269591342 @default.
• W2026959134 hasOpenAccess W2026959134 @default.
• W2026959134 hasPrimaryLocation W20269591341 @default.
• W2026959134 hasRelatedWork W1967984358 @default.
• W2026959134 hasRelatedWork W2004305725 @default.
• W2026959134 hasRelatedWork W2052719208 @default.
• W2026959134 hasRelatedWork W2068733538 @default.
• W2026959134 hasRelatedWork W2074087098 @default.
• W2026959134 hasRelatedWork W2111611782 @default.
• W2026959134 hasRelatedWork W2127532387 @default.
• W2026959134 hasRelatedWork W2140892602 @default.
• W2026959134 hasRelatedWork W2390995778 @default.
• W2026959134 hasRelatedWork W4284879194 @default.
• W2026959134 hasVolume "103" @default.
• W2026959134 isParatext "false" @default.
• W2026959134 isRetracted "false" @default.
• W2026959134 magId "2026959134" @default.

• next