FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026963485> ?p ?o ?g. }

• W2026963485 endingPage "1155" @default.
• W2026963485 startingPage "1148" @default.
• W2026963485 abstract "Midthoracic spinal cord injury (SCI) is associated with enhanced cardiac sympathetic activity and reduced cardiac parasympathetic activity. The enhanced cardiac sympathetic activity is associated with sympathetic structural plasticity within the stellate ganglia, spinal cord segments T 1 –T 4 , and heart. However, changes to cardiac parasympathetic centers rostral to an experimental SCI are relatively unknown. Importantly, reduced vagal activity is a predictor of high mortality. Furthermore, this autonomic dysregulation promotes progressive left ventricular (LV) structural remodeling. Accordingly, we hypothesized that midthoracic spinal cord injury is associated with structural plasticity in premotor (preganglionic parasympathetic neurons) cardioinhibitory vagal neurons located within the nucleus ambiguus as well as LV structural remodeling. To test this hypothesis, dendritic arborization and morphology (cholera toxin B immunohistochemistry and Sholl analysis) of cardiac projecting premotor cardioinhibitory vagal neurons located within the nucleus ambiguus were determined in intact (sham transected) and thoracic level 5 transected (T 5 X) rats. In addition, LV chamber size, wall thickness, and collagen content (Masson trichrome stain and structural analysis) were determined. Midthoracic SCI was associated with structural changes within the nucleus ambiguus and heart. Specifically, following T 5 spinal cord transection, there was a significant increase in cardiac parasympathetic preganglionic neuron dendritic arborization, soma area, maximum dendritic length, and number of intersections/animal. This parasympathetic structural remodeling was associated with a profound LV structural remodeling. Specifically, T 5 spinal cord transection increased LV chamber area, reduced LV wall thickness, and increased collagen content. Accordingly, results document a dynamic interaction between the heart and its parasympathetic innervation." @default.
• W2026963485 created "2016-06-24" @default.
• W2026963485 creator A5004180204 @default.
• W2026963485 creator A5066666096 @default.
• W2026963485 creator A5085603529 @default.
• W2026963485 date "2014-05-01" @default.
• W2026963485 modified "2023-09-30" @default.
• W2026963485 title "Structural remodeling of the heart and its premotor cardioinhibitory vagal neurons following T₅ spinal cord transection" @default.
• W2026963485 cites W1499093845 @default.
• W2026963485 cites W1545494857 @default.
• W2026963485 cites W1551323416 @default.
• W2026963485 cites W1605889901 @default.
• W2026963485 cites W1793704470 @default.
• W2026963485 cites W1794305500 @default.
• W2026963485 cites W1820192366 @default.
• W2026963485 cites W1967337107 @default.
• W2026963485 cites W1971269825 @default.
• W2026963485 cites W1976312625 @default.
• W2026963485 cites W1977714799 @default.
• W2026963485 cites W1978626633 @default.
• W2026963485 cites W1984837480 @default.
• W2026963485 cites W1986660749 @default.
• W2026963485 cites W1986696484 @default.
• W2026963485 cites W1991802902 @default.
• W2026963485 cites W1995269583 @default.
• W2026963485 cites W2002261021 @default.
• W2026963485 cites W2002406661 @default.
• W2026963485 cites W2006503119 @default.
• W2026963485 cites W2008125380 @default.
• W2026963485 cites W2009630172 @default.
• W2026963485 cites W2011393212 @default.
• W2026963485 cites W2015224281 @default.
• W2026963485 cites W2015286983 @default.
• W2026963485 cites W2018625297 @default.
• W2026963485 cites W2020569278 @default.
• W2026963485 cites W2021518416 @default.
• W2026963485 cites W2023586459 @default.
• W2026963485 cites W2024413208 @default.
• W2026963485 cites W2029492124 @default.
• W2026963485 cites W2037112143 @default.
• W2026963485 cites W2040671543 @default.
• W2026963485 cites W2040937463 @default.
• W2026963485 cites W2053491059 @default.
• W2026963485 cites W2055670853 @default.
• W2026963485 cites W2056169505 @default.
• W2026963485 cites W2056665255 @default.
• W2026963485 cites W2057869445 @default.
• W2026963485 cites W2060067875 @default.
• W2026963485 cites W2062414497 @default.
• W2026963485 cites W2063280447 @default.
• W2026963485 cites W2065920701 @default.
• W2026963485 cites W2068884498 @default.
• W2026963485 cites W2069211850 @default.
• W2026963485 cites W2070370785 @default.
• W2026963485 cites W2076973182 @default.
• W2026963485 cites W2080846812 @default.
• W2026963485 cites W2083792839 @default.
• W2026963485 cites W2086736256 @default.
• W2026963485 cites W2089099371 @default.
• W2026963485 cites W2093987643 @default.
• W2026963485 cites W2098484701 @default.
• W2026963485 cites W2108128316 @default.
• W2026963485 cites W2109855905 @default.
• W2026963485 cites W2110269539 @default.
• W2026963485 cites W2113732155 @default.
• W2026963485 cites W2115213903 @default.
• W2026963485 cites W2123181530 @default.
• W2026963485 cites W2128948878 @default.
• W2026963485 cites W2136601553 @default.
• W2026963485 cites W2136642260 @default.
• W2026963485 cites W2137625635 @default.
• W2026963485 cites W2141020047 @default.
• W2026963485 cites W2143048949 @default.
• W2026963485 cites W2143425349 @default.
• W2026963485 cites W2143745654 @default.
• W2026963485 cites W2145912168 @default.
• W2026963485 cites W2154545174 @default.
• W2026963485 cites W2156784577 @default.
• W2026963485 cites W2179717202 @default.
• W2026963485 cites W2396446279 @default.
• W2026963485 cites W2411015360 @default.
• W2026963485 cites W2411799647 @default.
• W2026963485 cites W4211110090 @default.
• W2026963485 doi "https://doi.org/10.1152/japplphysiol.01285.2013" @default.
• W2026963485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4097824" @default.
• W2026963485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24610530" @default.
• W2026963485 hasPublicationYear "2014" @default.
• W2026963485 type Work @default.
• W2026963485 sameAs 2026963485 @default.
• W2026963485 citedByCount "18" @default.
• W2026963485 countsByYear W20269634852015 @default.
• W2026963485 countsByYear W20269634852016 @default.
• W2026963485 countsByYear W20269634852017 @default.
• W2026963485 countsByYear W20269634852018 @default.
• W2026963485 countsByYear W20269634852019 @default.
• W2026963485 countsByYear W20269634852020 @default.
• W2026963485 countsByYear W20269634852021 @default.
• W2026963485 countsByYear W20269634852022 @default.

• next