FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026978096> ?p ?o ?g. }

• W2026978096 endingPage "386" @default.
• W2026978096 startingPage "375" @default.
• W2026978096 abstract "Background: Stromelysin belongs to a family of zinc-dependent endopeptidases referred to as matrix metalloproteinases (MMPs, matrixins) because of their capacity for selective degradation of various components of the extracellular matrix. Matrixins play key roles in diseases as diverse as arthritis and cancer and hence are important targets for therapeutic intervention.Results The crystal structure of the stromelysin catalytic domain (SCD) with bound hydroxamate inhibitor, solved by multiple isomorphous replacement, shows a deep S1′ specificity pocket which explains differences in inhibitor binding between the collagenases and stromelysin. The binding of calcium ions by loops at the two ends of a β-strand which marks the boundary of the active site provides a structural rationale for the importance of these cations for stability and catalytic activity. Major differences between the matrixins are clustered in two regions forming the entrance to the active site and hence may be determinants of substrate selectivity.Conclusion Structural comparisons of SCD with representative members of the metalloproteinase superfamily clearly highlight the conservation of key secondary structural elements, in spite of major variations in the sequences including insertions and deletions of functional domains. However, the three-dimensional structure of SCD, which is generally closely related to the collagenases, shows significant differences not only in the peripheral regions but also in the specificity pockets; these latter differences should facilitate the rational design of specific inhibitors." @default.
• W2026978096 created "2016-06-24" @default.
• W2026978096 creator A5001029093 @default.
• W2026978096 creator A5008564508 @default.
• W2026978096 creator A5036676601 @default.
• W2026978096 creator A5043483484 @default.
• W2026978096 creator A5053480075 @default.
• W2026978096 creator A5057108969 @default.
• W2026978096 creator A5070728610 @default.
• W2026978096 creator A5074849589 @default.
• W2026978096 creator A5078656952 @default.
• W2026978096 creator A5088905337 @default.
• W2026978096 date "1996-04-01" @default.
• W2026978096 modified "2023-10-02" @default.
• W2026978096 title "X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily" @default.
• W2026978096 cites W1487053853 @default.
• W2026978096 cites W1488746545 @default.
• W2026978096 cites W1493755221 @default.
• W2026978096 cites W1494656326 @default.
• W2026978096 cites W1505402212 @default.
• W2026978096 cites W1660900149 @default.
• W2026978096 cites W1668309971 @default.
• W2026978096 cites W1700189391 @default.
• W2026978096 cites W1835135188 @default.
• W2026978096 cites W1844893699 @default.
• W2026978096 cites W1951248594 @default.
• W2026978096 cites W1963698879 @default.
• W2026978096 cites W1966041739 @default.
• W2026978096 cites W1968539554 @default.
• W2026978096 cites W1979390430 @default.
• W2026978096 cites W1988860642 @default.
• W2026978096 cites W1991063206 @default.
• W2026978096 cites W1997670079 @default.
• W2026978096 cites W1998491594 @default.
• W2026978096 cites W2001641653 @default.
• W2026978096 cites W2012149653 @default.
• W2026978096 cites W2013083986 @default.
• W2026978096 cites W2019838731 @default.
• W2026978096 cites W2024876937 @default.
• W2026978096 cites W2028129929 @default.
• W2026978096 cites W2028231353 @default.
• W2026978096 cites W2036805996 @default.
• W2026978096 cites W2037412273 @default.
• W2026978096 cites W2041233605 @default.
• W2026978096 cites W2041533977 @default.
• W2026978096 cites W2044425673 @default.
• W2026978096 cites W2048659997 @default.
• W2026978096 cites W2049115197 @default.
• W2026978096 cites W2049521571 @default.
• W2026978096 cites W2049589142 @default.
• W2026978096 cites W2051737636 @default.
• W2026978096 cites W2053150534 @default.
• W2026978096 cites W2057200339 @default.
• W2026978096 cites W2058878095 @default.
• W2026978096 cites W2062784484 @default.
• W2026978096 cites W2065385636 @default.
• W2026978096 cites W2069118847 @default.
• W2026978096 cites W2074016505 @default.
• W2026978096 cites W2086165974 @default.
• W2026978096 cites W2094357306 @default.
• W2026978096 cites W2109658199 @default.
• W2026978096 cites W2115732278 @default.
• W2026978096 cites W2128516811 @default.
• W2026978096 cites W2147145439 @default.
• W2026978096 cites W2158198055 @default.
• W2026978096 cites W2159692814 @default.
• W2026978096 cites W4254275792 @default.
• W2026978096 doi "https://doi.org/10.1016/s0969-2126(96)00043-3" @default.
• W2026978096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8740360" @default.
• W2026978096 hasPublicationYear "1996" @default.
• W2026978096 type Work @default.
• W2026978096 sameAs 2026978096 @default.
• W2026978096 citedByCount "102" @default.
• W2026978096 countsByYear W20269780962012 @default.
• W2026978096 countsByYear W20269780962013 @default.
• W2026978096 countsByYear W20269780962014 @default.
• W2026978096 countsByYear W20269780962015 @default.
• W2026978096 countsByYear W20269780962016 @default.
• W2026978096 countsByYear W20269780962017 @default.
• W2026978096 countsByYear W20269780962018 @default.
• W2026978096 countsByYear W20269780962020 @default.
• W2026978096 crossrefType "journal-article" @default.
• W2026978096 hasAuthorship W2026978096A5001029093 @default.
• W2026978096 hasAuthorship W2026978096A5008564508 @default.
• W2026978096 hasAuthorship W2026978096A5036676601 @default.
• W2026978096 hasAuthorship W2026978096A5043483484 @default.
• W2026978096 hasAuthorship W2026978096A5053480075 @default.
• W2026978096 hasAuthorship W2026978096A5057108969 @default.
• W2026978096 hasAuthorship W2026978096A5070728610 @default.
• W2026978096 hasAuthorship W2026978096A5074849589 @default.
• W2026978096 hasAuthorship W2026978096A5078656952 @default.
• W2026978096 hasAuthorship W2026978096A5088905337 @default.
• W2026978096 hasBestOaLocation W20269780961 @default.
• W2026978096 hasConcept C107824862 @default.
• W2026978096 hasConcept C109523444 @default.
• W2026978096 hasConcept C181199279 @default.
• W2026978096 hasConcept C185592680 @default.
• W2026978096 hasConcept C2778394429 @default.

• next