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• W2026989597 abstract "Interleukin-4 (IL-4) plays a central role in the pathogenesis of allergic inflammation by inducing Ig class switch to IgE. IL-4 is also the most potent factor that drives naive T helper (Th) cells to differentiate to the Th2 phenotype. Recently, efforts have been made to explore the molecular basis of the Th2-specific IL-4 expression in CD4 T cells. Transcription factors, such as GATA-3, NF-IL6 and c-Maf, were found to be preferentially expressed in Th2 cells and to play an important role in regulation of the IL-4 promoter activity. Yet, other transcription factors may be indirectly involved in Th2-specific expression of IL-4 even though they are present in both Th1 and Th2 cells. In conclusion, Th2-specific expression of the IL-4 gene appears to be controlled by a multi-factor-system." @default.
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• W2026989597 date "1997-12-01" @default.
• W2026989597 modified "2023-09-26" @default.
• W2026989597 title "What Controls Tissue-specific Expression of the IL-4 Gene?" @default.
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• W2026989597 doi "https://doi.org/10.1016/s0171-2985(97)80038-1" @default.
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