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• W2026996919 abstract "This work is a modified version of the Casey Holter Memorial prize essay presented to the Society for Research into Hydrocephalus and Spina Bifida, June 29th 2007, Heidelberg, Germany. It describes the origin and consequences of the Chiari malformation, and proposes that hydrocephalus is caused by inadequate central nervous system (CNS) venous drainage. A new hypothesis regarding the pathogenesis, anencephaly and spina bifida is described.Any volume increase in the central nervous system can increase venous pressure. This occurs because veins are compressible and a CNS volume increase may result in reduced venous blood flow. This has the potential to cause progressive increase in cerebrospinal fluid (CSF) volume. Venous insufficiency may be caused by any disease that reduces space for venous volume. The flow of CSF has a beneficial effect on venous drainage. In health it moderates central nervous system pressure by moving between the head and spine. Conversely, obstruction to CSF flow causes localised pressure increases, which have an adverse effect on venous drainage.The Chiari malformation is associated with hindbrain herniation, which may be caused by low spinal pressure relative to cranial pressure. In these instances, there are hindbrain-related symptoms caused by cerebellar and brainstem compression. When spinal injury occurs as a result of a Chiari malformation, the primary pathology is posterior fossa hypoplasia, resulting in raised spinal pressure. The small posterior fossa prevents the flow of CSF from the spine to the head as blood enters the central nervous system during movement. Consequently, intermittent increases in spinal pressure caused by movement, result in injury to the spinal cord. It is proposed that posterior fossa hypoplasia, which has origins in fetal life, causes syringomyelia after birth and leads to damage to the spinal cord in spina bifida. It is proposed that hydrocephalus may occur as a result of posterior fossa hypoplasia, where raised pressure occurs as a result of obstruction to flow of CSF from the head to the spine, and cerebral injury with raised pressure occurs in anencephaly by this mechanism.The current view of dysraphism is that low central nervous system pressure and exposure to amniotic fluid, damage the central nervous system. The hypothesis proposed in this essay supports the view that spina bifida is a manifestation of progressive hydrocephalus in the fetus. It is proposed that that mesodermal growth insufficiency influences both neural tube closure and central nervous system pressure, leading to dysraphism." @default.
• W2026996919 created "2016-06-24" @default.
• W2026996919 creator A5018115258 @default.
• W2026996919 date "2008-04-11" @default.
• W2026996919 modified "2023-10-01" @default.
• W2026996919 title "A unifying hypothesis for hydrocephalus, Chiari malformation, syringomyelia, anencephaly and spina bifida" @default.
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• W2026996919 cites W1965924530 @default.
• W2026996919 cites W1972697119 @default.
• W2026996919 cites W1973349845 @default.
• W2026996919 cites W1974426595 @default.
• W2026996919 cites W1979058607 @default.
• W2026996919 cites W1981273072 @default.
• W2026996919 cites W1982474448 @default.
• W2026996919 cites W1988280787 @default.
• W2026996919 cites W1994243010 @default.
• W2026996919 cites W2000466566 @default.
• W2026996919 cites W2001015064 @default.
• W2026996919 cites W2005234383 @default.
• W2026996919 cites W2006790294 @default.
• W2026996919 cites W2012396836 @default.
• W2026996919 cites W2028720542 @default.
• W2026996919 cites W2032091477 @default.
• W2026996919 cites W2033949364 @default.
• W2026996919 cites W2036941731 @default.
• W2026996919 cites W2046078338 @default.
• W2026996919 cites W2046710855 @default.
• W2026996919 cites W2047019995 @default.
• W2026996919 cites W2047438092 @default.
• W2026996919 cites W2059112126 @default.
• W2026996919 cites W2059269849 @default.
• W2026996919 cites W2059385068 @default.
• W2026996919 cites W2059878203 @default.
• W2026996919 cites W2065329442 @default.
• W2026996919 cites W2065686315 @default.
• W2026996919 cites W2068469125 @default.
• W2026996919 cites W2072788885 @default.
• W2026996919 cites W2078709480 @default.
• W2026996919 cites W2083316173 @default.
• W2026996919 cites W2085497155 @default.
• W2026996919 cites W2087055502 @default.
• W2026996919 cites W2092388905 @default.
• W2026996919 cites W2097546287 @default.
• W2026996919 cites W2101359291 @default.
• W2026996919 cites W2101567007 @default.
• W2026996919 cites W2101910462 @default.
• W2026996919 cites W2107615644 @default.
• W2026996919 cites W2111698734 @default.
• W2026996919 cites W2111795523 @default.
• W2026996919 cites W2115071553 @default.
• W2026996919 cites W2122263843 @default.
• W2026996919 cites W2122696720 @default.
• W2026996919 cites W2123955832 @default.
• W2026996919 cites W2126602013 @default.
• W2026996919 cites W2130929362 @default.
• W2026996919 cites W2136669156 @default.
• W2026996919 cites W2138792985 @default.
• W2026996919 cites W2139254424 @default.
• W2026996919 cites W2139627594 @default.
• W2026996919 cites W2144083195 @default.
• W2026996919 cites W2144350594 @default.
• W2026996919 cites W2149517580 @default.
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• W2026996919 cites W2152020610 @default.
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• W2026996919 cites W2167121627 @default.
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• W2026996919 cites W2911264056 @default.
• W2026996919 cites W3168218752 @default.
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• W2026996919 doi "https://doi.org/10.1186/1743-8454-5-7" @default.
• W2026996919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2365936" @default.
• W2026996919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18405364" @default.
• W2026996919 hasPublicationYear "2008" @default.
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