Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026996968> ?p ?o ?g. }
- W2026996968 endingPage "80" @default.
- W2026996968 startingPage "66" @default.
- W2026996968 abstract "Lectins are a heterogeneous group of proteins found in plants, animals and microorganisms, which possess at least one non-catalytic domain that binds reversibly to specific mono- or oligosaccharides. The range of lectins and respective biological activities is unsurprising given the immense diversity and complexity of glycan structures and the multiple modes of interaction with proteins. Recombinant DNA technology has been traditionally used for cloning and characterizing newly discovered lectins. It has also been employed as a means of producing pure and sequence-defined lectins for different biotechnological applications. This review focuses on the production of recombinant lectins in heterologous organisms, and highlighting the Escherichia coli and Pichia pastoris expression systems, which are the most employed. The choice of expression host depends on the lectin. Non-glycosylated recombinant lectins are produced in E. coli and post-translational modified recombinant lectins are produced in eukaryotic organisms, namely P. pastoris and non-microbial hosts such as mammalian cells. Emphasis is given to the applications of the recombinant lectins especially (a) in cancer diagnosis and/or therapeutics, (b) as anti-microbial, anti-viral, and anti-insect molecules or (c) in microarrays for glycome profiling. Most reported applications are from recombinant plant lectins. These applications benefit from the tailor-made design associated with recombinant production and will aid in unraveling the complex biological mechanisms of glycan-interactions, bringing recombinant lectins to the forefront of glycobiology. In conclusion, recombinant lectins are developing into valuable biosynthetic tools for biomedical research." @default.
- W2026996968 created "2016-06-24" @default.
- W2026996968 creator A5004106469 @default.
- W2026996968 creator A5031274455 @default.
- W2026996968 creator A5041700821 @default.
- W2026996968 date "2012-04-24" @default.
- W2026996968 modified "2023-09-29" @default.
- W2026996968 title "Recombinant lectins: an array of tailor-made glycan-interaction biosynthetic tools" @default.
- W2026996968 cites W119062889 @default.
- W2026996968 cites W143313177 @default.
- W2026996968 cites W1481355576 @default.
- W2026996968 cites W1544637792 @default.
- W2026996968 cites W1696872742 @default.
- W2026996968 cites W171962313 @default.
- W2026996968 cites W1778363845 @default.
- W2026996968 cites W1803686092 @default.
- W2026996968 cites W1963814231 @default.
- W2026996968 cites W1965152800 @default.
- W2026996968 cites W1966121685 @default.
- W2026996968 cites W1970157167 @default.
- W2026996968 cites W1970688271 @default.
- W2026996968 cites W1972478322 @default.
- W2026996968 cites W1973658789 @default.
- W2026996968 cites W1974358140 @default.
- W2026996968 cites W1974825004 @default.
- W2026996968 cites W1974982914 @default.
- W2026996968 cites W1975648382 @default.
- W2026996968 cites W1978350138 @default.
- W2026996968 cites W1978663986 @default.
- W2026996968 cites W1979916844 @default.
- W2026996968 cites W1980153360 @default.
- W2026996968 cites W1982296419 @default.
- W2026996968 cites W1985562190 @default.
- W2026996968 cites W1985730191 @default.
- W2026996968 cites W1986593268 @default.
- W2026996968 cites W1986753899 @default.
- W2026996968 cites W1988336236 @default.
- W2026996968 cites W1991661108 @default.
- W2026996968 cites W1991890196 @default.
- W2026996968 cites W1994125686 @default.
- W2026996968 cites W1999768858 @default.
- W2026996968 cites W2002119390 @default.
- W2026996968 cites W2007822974 @default.
- W2026996968 cites W2007858645 @default.
- W2026996968 cites W2009447145 @default.
- W2026996968 cites W2009895455 @default.
- W2026996968 cites W2010980655 @default.
- W2026996968 cites W2010999015 @default.
- W2026996968 cites W2013053730 @default.
- W2026996968 cites W2015585084 @default.
- W2026996968 cites W2017526934 @default.
- W2026996968 cites W2017821695 @default.
- W2026996968 cites W2019635937 @default.
- W2026996968 cites W2019869944 @default.
- W2026996968 cites W2024956600 @default.
- W2026996968 cites W2025968892 @default.
- W2026996968 cites W2026022607 @default.
- W2026996968 cites W2026318024 @default.
- W2026996968 cites W2026568060 @default.
- W2026996968 cites W2027652648 @default.
- W2026996968 cites W2029185450 @default.
- W2026996968 cites W2030070877 @default.
- W2026996968 cites W2031026602 @default.
- W2026996968 cites W2031852128 @default.
- W2026996968 cites W2036178456 @default.
- W2026996968 cites W2039350840 @default.
- W2026996968 cites W2046605974 @default.
- W2026996968 cites W2048644291 @default.
- W2026996968 cites W2048787646 @default.
- W2026996968 cites W2049322319 @default.
- W2026996968 cites W2050036613 @default.
- W2026996968 cites W2055498841 @default.
- W2026996968 cites W2057808590 @default.
- W2026996968 cites W2059267863 @default.
- W2026996968 cites W2062348697 @default.
- W2026996968 cites W2063554961 @default.
- W2026996968 cites W2063691016 @default.
- W2026996968 cites W2064092953 @default.
- W2026996968 cites W2064602273 @default.
- W2026996968 cites W2069716385 @default.
- W2026996968 cites W2071494868 @default.
- W2026996968 cites W2072542018 @default.
- W2026996968 cites W2073272616 @default.
- W2026996968 cites W2074419567 @default.
- W2026996968 cites W2075247459 @default.
- W2026996968 cites W2076667550 @default.
- W2026996968 cites W2077695597 @default.
- W2026996968 cites W2078464545 @default.
- W2026996968 cites W2080491926 @default.
- W2026996968 cites W2080653832 @default.
- W2026996968 cites W2086638135 @default.
- W2026996968 cites W2088328100 @default.
- W2026996968 cites W2098059264 @default.
- W2026996968 cites W2099169175 @default.
- W2026996968 cites W2101755213 @default.
- W2026996968 cites W2102427512 @default.
- W2026996968 cites W2103818937 @default.
- W2026996968 cites W2105376959 @default.