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- W2027000515 abstract "Letters1 January 1977Anti-Cephalothin Antibody and Coombs'-Positive Hemolytic AnemiaRONALD N. RUBIN, M.D., EDWARD R. BURKA, M.D.RONALD N. RUBIN, M.D.Search for more papers by this author, EDWARD R. BURKA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-64 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCephalothin therapy is associated with a positive direct antiglobulin test in 3% to 65% of patients receiving this drug (1, 2). Most often the responsible mechanism is nonimmune adsorption of serum proteins to cephalothin-exposed erythrocytes (3). Cephalothin-related hemolysis has been reported and is associated with specific anticephalothin antibodies (4, 5). We describe here a case of cephalothin-related Coombs' positive hemolytic anemia in which IgG antibody has been identified in the patient's serum and on erythrocytes.A 64-year-old white man was admitted to Thomas Jefferson University Hospital on 3 August 1975, for evaluation of chills...References1. MOLTHANREIDENBERGEICHMAN LMM: Positive direct Coombs tests due to cephalothin. N Engl J Med 277:123-125, 1967 CrossrefMedlineGoogle Scholar2. SPATHGARRATTYPETZ PGL: Studies on the immune response to penicillin and cephalothin in humans. II. Immunohematologic reactions to cephalothin administration. J Immunol 107:860-869, 1971 MedlineGoogle Scholar3. GARRATTYPETZ GL: Drug-induced hemolytic anemia. Am J Med 58:398-407, 1975 CrossrefMedlineGoogle Scholar4. GRALNICKMCGINNISSELTON HMW: Hemolytic anemia associated with cephalothin. JAMA 217:1193-1197, 1971 CrossrefMedlineGoogle Scholar5. JEANNETDAYERFARQUET MJJ: Cephalothin-induced immune hemolytic anemia. Acta Haematol (Basel) 55:109-117, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD N. RUBIN, M.D.; EDWARD R. BURKA, M.D.Affiliations: Cardeza Foundation for Hematologic Research Thomas Jefferson University Hospital 1015 Walnut Street Philadelphia, PA 19107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCephalothin and CefazolinThe Changing Spectrum of Drug-Induced Immune Hemolytic AnemiaDrug-Induced Immune Hemolytic AnemiaReview: drug-induced immune hemolytic anemia—the last decadeSerology of antibodies to second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin testsCefotetan-induced immune hemolytic anemia due to the drug-adsorption mechanismImmune Cytopenia Associated With AntibioticsCephalosporin-induced hemolysis: A case report and review of the literatureDifferential stimulation of lymphocyte cell growth in vitro by cephalosporinsSuppression of Lymphocytes by CephalosporinsSuppression of lymphocyte responses by cephalosporinsPenicillins, cephalosporins and tetracyclines 1 January 1977Volume 86, Issue 1Page: 64-65KeywordsAntibody therapyDrug therapyHemolytic anemiaSerum proteins ePublished: 1 December 2008 Issue Published: 1 January 1977 PDF downloadLoading ..." @default.
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- W2027000515 title "Anti-Cephalothin Antibody and Coombs'-Positive Hemolytic Anemia" @default.
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