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- W2027004252 abstract "The genomic RNA of Qβ virus is replicated by Qβ replicase, a template-dependent RNA polymerase complex. Qβ replicase has an intrinsic template-independent RNA 3′-adenylation activity, which is required for efficient viral RNA amplification in the host cells. However, the mechanism of the template-independent 3′-adenylation of RNAs by Qβ replicase has remained elusive. We determined the structure of a complex that includes Qβ replicase, a template RNA, a growing RNA complementary to the template RNA, and ATP. The structure represents the terminal stage of RNA polymerization and reveals that the shape and size of the nucleotide-binding pocket becomes available for ATP accommodation after the 3′-penultimate template-dependent C-addition. The stacking interaction between the ATP and the neighboring Watson-Crick base pair, between the 5′-G in the template and the 3′-C in the growing RNA, contributes to the nucleotide specificity. Thus, the template for the template-independent 3′-adenylation by Qβ replicase is the RNA and protein ribonucleoprotein complex." @default.
- W2027004252 created "2016-06-24" @default.
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- W2027004252 creator A5036917638 @default.
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- W2027004252 date "2012-10-01" @default.
- W2027004252 modified "2023-09-30" @default.
- W2027004252 title "Mechanism for Template-Independent Terminal Adenylation Activity of Qβ Replicase" @default.
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- W2027004252 doi "https://doi.org/10.1016/j.str.2012.07.004" @default.
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