FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027027613> ?p ?o ?g. }

• W2027027613 endingPage "2138" @default.
• W2027027613 startingPage "2133" @default.
• W2027027613 abstract "Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes. The enzymatic activity was first identified over four decades ago, and is deficient in the inherited lipid storage disorder, Farber Lipogranulomatosis (Farber disease). Importantly, AC not only hydrolyzes ceramide into sphingosine, but also can synthesize ceramide from sphingosine and free fatty acids in vitro and in situ. This “reverse” enzymatic activity occurs at a distinct pH from the hydrolysis (“forward”) reaction (6.0 vs. 4.5, respectively), suggesting that the enzyme may have diverse functions within cells dependent on its subcellular location and the local pH. Most information concerning the role of AC in human disease stems from work on Farber disease. This lipid storage disease is caused by mutations in the gene encoding AC, leading to a profound reduction in enzymatic activity. Recent studies have also shown that AC activity is aberrantly expressed in several human cancers, and that the enzyme may be a useful cancer drug target. For example, AC inhibitors have been used to slow the growth of cancer cells, alone or in combination with other established, anti-oncogenic treatments. Aberrant AC activity also has been described in Alzheimer's disease, and overexpression of AC may prevent insulin resistant (Type II) diabetes induced by free fatty acids. Current information concerning the biology of this enzyme and its role in human disease is reviewed within." @default.
• W2027027613 created "2016-06-24" @default.
• W2027027613 creator A5010341943 @default.
• W2027027613 creator A5034341624 @default.
• W2027027613 date "2006-12-01" @default.
• W2027027613 modified "2023-10-17" @default.
• W2027027613 title "Acid ceramidase and human disease" @default.
• W2027027613 cites W120197159 @default.
• W2027027613 cites W1517500969 @default.
• W2027027613 cites W1552641940 @default.
• W2027027613 cites W1570743730 @default.
• W2027027613 cites W1647156299 @default.
• W2027027613 cites W1969307681 @default.
• W2027027613 cites W1979201237 @default.
• W2027027613 cites W1981033063 @default.
• W2027027613 cites W1983347881 @default.
• W2027027613 cites W1984745753 @default.
• W2027027613 cites W1988374405 @default.
• W2027027613 cites W1988475564 @default.
• W2027027613 cites W1993612779 @default.
• W2027027613 cites W1994091700 @default.
• W2027027613 cites W1995687483 @default.
• W2027027613 cites W2001946573 @default.
• W2027027613 cites W2007222184 @default.
• W2027027613 cites W2008085628 @default.
• W2027027613 cites W2009155924 @default.
• W2027027613 cites W2010393408 @default.
• W2027027613 cites W2017231139 @default.
• W2027027613 cites W2017393429 @default.
• W2027027613 cites W2021259615 @default.
• W2027027613 cites W202230465 @default.
• W2027027613 cites W2025338956 @default.
• W2027027613 cites W2028579839 @default.
• W2027027613 cites W2033666577 @default.
• W2027027613 cites W2039321321 @default.
• W2027027613 cites W2063653985 @default.
• W2027027613 cites W2064601706 @default.
• W2027027613 cites W2072666407 @default.
• W2027027613 cites W2091800193 @default.
• W2027027613 cites W2093923977 @default.
• W2027027613 cites W2109222567 @default.
• W2027027613 cites W2110663159 @default.
• W2027027613 cites W2112733125 @default.
• W2027027613 cites W2115137049 @default.
• W2027027613 cites W2123149430 @default.
• W2027027613 cites W2148916302 @default.
• W2027027613 cites W4248474603 @default.
• W2027027613 doi "https://doi.org/10.1016/j.bbamem.2006.08.019" @default.
• W2027027613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17064658" @default.
• W2027027613 hasPublicationYear "2006" @default.
• W2027027613 type Work @default.
• W2027027613 sameAs 2027027613 @default.
• W2027027613 citedByCount "175" @default.
• W2027027613 countsByYear W20270276132012 @default.
• W2027027613 countsByYear W20270276132013 @default.
• W2027027613 countsByYear W20270276132014 @default.
• W2027027613 countsByYear W20270276132015 @default.
• W2027027613 countsByYear W20270276132016 @default.
• W2027027613 countsByYear W20270276132017 @default.
• W2027027613 countsByYear W20270276132018 @default.
• W2027027613 countsByYear W20270276132019 @default.
• W2027027613 countsByYear W20270276132020 @default.
• W2027027613 countsByYear W20270276132021 @default.
• W2027027613 countsByYear W20270276132022 @default.
• W2027027613 countsByYear W20270276132023 @default.
• W2027027613 crossrefType "journal-article" @default.
• W2027027613 hasAuthorship W2027027613A5010341943 @default.
• W2027027613 hasAuthorship W2027027613A5034341624 @default.
• W2027027613 hasBestOaLocation W20270276131 @default.
• W2027027613 hasConcept C170493617 @default.
• W2027027613 hasConcept C180899940 @default.
• W2027027613 hasConcept C181199279 @default.
• W2027027613 hasConcept C185592680 @default.
• W2027027613 hasConcept C190283241 @default.
• W2027027613 hasConcept C2777851122 @default.
• W2027027613 hasConcept C2778703144 @default.
• W2027027613 hasConcept C543025807 @default.
• W2027027613 hasConcept C55493867 @default.
• W2027027613 hasConcept C61705674 @default.
• W2027027613 hasConcept C86803240 @default.
• W2027027613 hasConceptScore W2027027613C170493617 @default.
• W2027027613 hasConceptScore W2027027613C180899940 @default.
• W2027027613 hasConceptScore W2027027613C181199279 @default.
• W2027027613 hasConceptScore W2027027613C185592680 @default.
• W2027027613 hasConceptScore W2027027613C190283241 @default.
• W2027027613 hasConceptScore W2027027613C2777851122 @default.
• W2027027613 hasConceptScore W2027027613C2778703144 @default.
• W2027027613 hasConceptScore W2027027613C543025807 @default.
• W2027027613 hasConceptScore W2027027613C55493867 @default.
• W2027027613 hasConceptScore W2027027613C61705674 @default.
• W2027027613 hasConceptScore W2027027613C86803240 @default.
• W2027027613 hasIssue "12" @default.
• W2027027613 hasLocation W20270276131 @default.
• W2027027613 hasLocation W20270276132 @default.
• W2027027613 hasOpenAccess W2027027613 @default.
• W2027027613 hasPrimaryLocation W20270276131 @default.
• W2027027613 hasRelatedWork W104784336 @default.
• W2027027613 hasRelatedWork W1567111656 @default.

• next