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- W2027030400 abstract "In establishing the pharmacological profile of Byrsocarpus coccineus, we investigated the CNS effects of the aqueous leaf extract using the Y-maze, hexobarbitone sleeping time and hole board models in mice. In the Y-maze test, Byrsocarpus coccineus, BC (50–100mg/kg, p.o.) produced significant (P<0.05) increases in the time spent in the open arm at post-treatment times of 30–90min. Peak effect was elicited at 100mg/kg 30min post-treatment, with mice spending 2.63±0.21min in the open arm vs. 0.62±0.21min for control. This effect was significantly higher than that of diazepam, 1mg/kg p.o. (2.00±0.20min). At doses of 200 and 400mg/kg, the effect of BC in increasing the time spent in the open arm diminished with the effect at the higher dose (1.24±0.29min) being not significantly different from the control. In the hexobarbitone sleeping time test, BC (50–100mg/kg) increased the onset and decreased the duration of sleep, with effects only being significant at 100mg/kg (onset=7.00±1.18min and duration=10.00±1.84min vs. onset=3.43±0.81min and duration=20.71±2.34min for control). At doses of 200 and 400mg/kg, BC decreased onset and significantly increased sleeping time with the effect at the higher dose (onset=3.29±0.61min and duration=39.86±3.78min) being significantly lower than that of diazepam, 3mg/kg p.o., in respect of duration of sleep only (onset=3.14±0.26min and duration=87.29±9.87min). In the modified hole board experiment, BC (50–100mg/kg) caused an increase in both exploratory activity and locomotion, while at 200 and 400mg/kg the reverse was the case. These effects were not significant. Diazepam, 1mg/kg p.o., caused a non-significant increase in exploratory activity and a significant increase in locomotion (25.71±4.44 sectional crossings in 5min vs. 10.86±2.30 sectional crossings in 5min for control). Results obtained suggest that the aqueous leaf extract of Byrsocarpus coccineus possess a dose determined anxiolytic – sedative activity with no effect on exploratory activity and locomotion." @default.
- W2027030400 created "2016-06-24" @default.
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- W2027030400 date "2007-01-01" @default.
- W2027030400 modified "2023-10-18" @default.
- W2027030400 title "Effects of Byrsocarpus coccineus (Connaraceae) extract on the central nervous system (CNS)" @default.
- W2027030400 doi "https://doi.org/10.1055/s-2007-986762" @default.
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