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• W2027030436 abstract "In this issue, Cole et al (1) report on the performance of a photon-counting digital mammography system (PCM) compared to a more established conventional full-field digital mammography (FFDM) system under clinically relevant image interpretation conditions involving 16 radiologists. The study was aimed at demonstrating noninferiority of PCM compared to the FFDM reference standard. In this study, the performance of two distinctly different digital mammography systems was evaluated using an enriched population that included 133 women, 67 of whom had a recent conventional FFDM procedure and prospective PCM in this presumed normal group, and 66 women with actionable findings from mammography who had prospective PCM and FFDM. This group yielded 49 cancers and 17 benign findings. The strategy of using a cancer-enriched population in such noninferiority studies that assess one imaging technology versus another that serves as the reference standard provides a powerful and efficient tool for the assessment of the performance of the candidate modality. The analysis of performance in this study included relative sensitivity, probability of malignancy assessment, specificity and lesion level analysis, and radiation dose. FFDM has emerged as the new standard that has essentially replaced screen-film mammography. The development and clinical deployment of FFDM had to overcome formidable challenges from the perspective of technological and clinical implementation. Full confidence in the superiorityof this technology over film-screen was not established until the results of several clinical investigations were published (2–4). Presently, FFDM systems from about a dozen different manufacturers are commercially available and are in widespread use; some of this equipment is already in the second or third generation. At the time of this report, 86% of all mammography units in the United States are digital (5) and nearly 100% conversion to digital is expected in the next two years." @default.
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• W2027030436 title "Photon-Counting Digital Mammography" @default.
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• W2027030436 doi "https://doi.org/10.1016/j.acra.2012.05.007" @default.
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