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• W2027075319 abstract "The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer genome. We uncovered two distinct mechanisms by which NKX3-1 controls the AR transcriptional network in prostate cancer. First, NKX3-1 and AR directly regulate each other in a feed-forward regulatory loop. Second, NKX3-1 collaborates with AR and FoxA1 to mediate genes in advanced and recurrent prostate carcinoma. NKX3-1- and AR-coregulated genes include those found in the “protein trafficking” process, which integrates oncogenic signaling pathways. Moreover, we demonstrate that NKX3-1, AR, and FoxA1 promote prostate cancer cell survival by directly upregulating RAB3B, a member of the RAB GTPase family. Finally, we show that RAB3B is overexpressed in prostate cancer patients, suggesting that RAB3B together with AR, FoxA1, and NKX3-1 are important regulators of prostate cancer progression. Collectively, our work highlights a novel hierarchical transcriptional regulatory network between NKX3-1, AR, and the RAB GTPase signaling pathway that is critical for the genetic-molecular-phenotypic paradigm in androgen-dependent prostate cancer." @default.
• W2027075319 created "2016-06-24" @default.
• W2027075319 creator A5012563463 @default.
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• W2027075319 date "2012-01-01" @default.
• W2027075319 modified "2023-10-18" @default.
• W2027075319 title "Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival" @default.
• W2027075319 cites W1493920337 @default.
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• W2027075319 cites W1970374717 @default.
• W2027075319 cites W1978833929 @default.
• W2027075319 cites W1980955330 @default.
• W2027075319 cites W1982057232 @default.
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• W2027075319 cites W1990529844 @default.
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• W2027075319 cites W2005658600 @default.
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• W2027075319 cites W2008663430 @default.
• W2027075319 cites W2012924225 @default.
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• W2027075319 cites W2023862781 @default.
• W2027075319 cites W2027515382 @default.
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• W2027075319 doi "https://doi.org/10.1128/mcb.05958-11" @default.
• W2027075319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3255774" @default.
• W2027075319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22083957" @default.
• W2027075319 hasPublicationYear "2012" @default.
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