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• W202708052 abstract "Despite treatment intensification for patients with head and neck squamous cell carcinoma (HNSCC), including altered radiation fractionation and the addition of chemotherapy to radiation, physicians and patients still face the challenge of recurrent or second tumors arising within or in close proximity to previously irradiated tissues. At 5 years after therapy, locoregional recurrences developed in 16%-25% of patients treated with definitive chemoradiation for larynx preservation (1) or with postoperative chemoradiation for high-risk HNSCC (2,3), and in 17%-52% of patients treated with definitive chemoradiation for locally advanced unresectable disease (4,5). Locally recurrent tumors may arise from residual neoplastic cells that survive initial treatment, perhaps because of biological parameters and tumor molecular profiles (6) associated with radiosensitivity (7). Insufficiencies in initial radiation treatment parameters, such as radiation dose, volume, fractionation, and treatment duration, were noted in a high percentage of patients enrolled on a small phase I trial of reirradiation (8) and are other potential sources of recurrence. Second cancers may arise from underlying field cancerization (9) as a radiation-induced malignancy or as a de novo process. A second HNSCC arising in the vicinity of the prior tumor may be indistinguishable from a local recurrence of the primary tumor (10). Approximately 15% of patients have developed a second primary cancer within 5 years of radiation alone for HNSCC, and approximately one-quarter of these are in the head and neck (11). Rationale for Retreatment Because locoregional tumor progression is the predominant cause of death in patients with head and neck cancer (12), achieving local control in patients with recurrent disease may impact survival. Indeed, results of a randomized trial in patients with recurrent HNSCC undergoing macroscopic complete salvage surgery found improved local control and disease-free survival in those receiving postoperative reirradiation with chemotherapy compared to observation (13). In that trial, retrospective analysis of a single institution experience found improved overall survival when local tumor control was achieved in patients reirradiated for recurrent head and neck cancer (14). In patients with recurrent or second primary tumors of the head and neck, local tumor growth is a potential source of great morbidity to include pain, disfigurement, bleeding, infection, and alteration of speech and swallowing. In a report of 150 patients reirradiated for head and neck cancer using stereotactic body radiotherapy (SBRT) with or without cetuximab, patient-reported quality of life, after an initial 1-month decline following reirradiation, noted progressive improvements in swallowing, speech, saliva, activity, and recreation, underlining the importance of local tumor control on patient quality of life (15)." @default.
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• W202708052 date "2014-01-01" @default.
• W202708052 modified "2023-09-26" @default.
• W202708052 title "RETREATMENT OF RECURRENT HEAD AND NECK CANCER AFTER PRIOR DEFINITIVE RADIATION" @default.
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• W202708052 cites W1991594828 @default.
• W202708052 cites W1991949008 @default.
• W202708052 cites W1992300421 @default.
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• W202708052 cites W2064454516 @default.
• W202708052 cites W2065900444 @default.
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