FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027091569> ?p ?o ?g. }

• W2027091569 endingPage "32" @default.
• W2027091569 startingPage "24" @default.
• W2027091569 abstract "Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder characterized by renal, hepatic and pancreatic cyst formation and cardiovascular complications. The condition is caused by mutations in the PKD1 or PKD2 gene. In mice with reduced expression of Pkd1, dissecting aneurysms with prominent media thickening have been seen. To study the effect of selective disruption of Pkd1 in vascular smooth muscle cells (SMCs), we have generated mice in which a floxed part of the Pkd1 gene was deleted by Cre under the control of the SM22 promotor (SM22-Pkd1(del/del) mice). Cre activity was confirmed by X-gal staining using lacZ expressing Cre reporter mice (R26R), and quantitative PCR indicated that in the aorta Pkd1 gene expression was strongly reduced, whereas Pkd2 levels remained unaltered. Histopathological analysis revealed cyst formation in pancreas, liver and kidneys as the result of extravascular Cre activity in pancreatic ducts, bile ducts and in the glomerular Bowman's capsule. Remarkably, we did not find any spontaneous gross structural blood vessel abnormalities in mice with somatic Pkd1 gene disruption in SMCs or simultaneous disruption of Pkd1 in SMCs and endothelial cells (ECs). Extensive isometric myographic analysis of the aorta did not reveal differences in response to KCl, acetylcholine, phenylephrin or serotonin, except for a significant increase in contractility induced by phenylephrin on arteries from 40 weeks old Pkd1(del/+) germ-line mice. However, SM22-Pkd1(del/del) mice showed significantly reduced decrease in heart rate on angiotensin II-induced hypertension. The present findings further demonstrate in vivo, that adaptation to hypertension is altered in SM22-Pkd1(del/del) mice." @default.
• W2027091569 created "2016-06-24" @default.
• W2027091569 creator A5002328386 @default.
• W2027091569 creator A5004743827 @default.
• W2027091569 creator A5013947762 @default.
• W2027091569 creator A5017879337 @default.
• W2027091569 creator A5039745921 @default.
• W2027091569 creator A5044560024 @default.
• W2027091569 creator A5045169208 @default.
• W2027091569 creator A5071022940 @default.
• W2027091569 creator A5072311778 @default.
• W2027091569 creator A5075814478 @default.
• W2027091569 creator A5079331578 @default.
• W2027091569 creator A5084192875 @default.
• W2027091569 creator A5088875022 @default.
• W2027091569 date "2011-01-01" @default.
• W2027091569 modified "2023-10-17" @default.
• W2027091569 title "Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension" @default.
• W2027091569 cites W1768274470 @default.
• W2027091569 cites W1894009041 @default.
• W2027091569 cites W1965166158 @default.
• W2027091569 cites W1969084423 @default.
• W2027091569 cites W1970445852 @default.
• W2027091569 cites W1975348834 @default.
• W2027091569 cites W1978777641 @default.
• W2027091569 cites W1994751739 @default.
• W2027091569 cites W1999374220 @default.
• W2027091569 cites W2000170902 @default.
• W2027091569 cites W2005702003 @default.
• W2027091569 cites W2017506108 @default.
• W2027091569 cites W2030927065 @default.
• W2027091569 cites W2042443829 @default.
• W2027091569 cites W2051209896 @default.
• W2027091569 cites W2053151867 @default.
• W2027091569 cites W2080853555 @default.
• W2027091569 cites W2093401766 @default.
• W2027091569 cites W2095137594 @default.
• W2027091569 cites W2096541584 @default.
• W2027091569 cites W2098567649 @default.
• W2027091569 cites W2103557245 @default.
• W2027091569 cites W2111016195 @default.
• W2027091569 cites W2113588019 @default.
• W2027091569 cites W2115962978 @default.
• W2027091569 cites W2121190335 @default.
• W2027091569 cites W2123474135 @default.
• W2027091569 cites W2124806953 @default.
• W2027091569 cites W2125720034 @default.
• W2027091569 cites W2128694053 @default.
• W2027091569 cites W2130211846 @default.
• W2027091569 cites W2130294960 @default.
• W2027091569 cites W2130477574 @default.
• W2027091569 cites W2135154052 @default.
• W2027091569 cites W2141313696 @default.
• W2027091569 cites W2145925521 @default.
• W2027091569 cites W2146969129 @default.
• W2027091569 cites W2159166763 @default.
• W2027091569 cites W2162583404 @default.
• W2027091569 cites W2163406006 @default.
• W2027091569 cites W2167467350 @default.
• W2027091569 cites W2171821069 @default.
• W2027091569 cites W2282558901 @default.
• W2027091569 cites W2398643839 @default.
• W2027091569 cites W3021964512 @default.
• W2027091569 doi "https://doi.org/10.1038/labinvest.2010.159" @default.
• W2027091569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20856231" @default.
• W2027091569 hasPublicationYear "2011" @default.
• W2027091569 type Work @default.
• W2027091569 sameAs 2027091569 @default.
• W2027091569 citedByCount "32" @default.
• W2027091569 countsByYear W20270915692012 @default.
• W2027091569 countsByYear W20270915692013 @default.
• W2027091569 countsByYear W20270915692014 @default.
• W2027091569 countsByYear W20270915692015 @default.
• W2027091569 countsByYear W20270915692016 @default.
• W2027091569 countsByYear W20270915692017 @default.
• W2027091569 countsByYear W20270915692018 @default.
• W2027091569 countsByYear W20270915692019 @default.
• W2027091569 countsByYear W20270915692020 @default.
• W2027091569 countsByYear W20270915692021 @default.
• W2027091569 countsByYear W20270915692022 @default.
• W2027091569 countsByYear W20270915692023 @default.
• W2027091569 crossrefType "journal-article" @default.
• W2027091569 hasAuthorship W2027091569A5002328386 @default.
• W2027091569 hasAuthorship W2027091569A5004743827 @default.
• W2027091569 hasAuthorship W2027091569A5013947762 @default.
• W2027091569 hasAuthorship W2027091569A5017879337 @default.
• W2027091569 hasAuthorship W2027091569A5039745921 @default.
• W2027091569 hasAuthorship W2027091569A5044560024 @default.
• W2027091569 hasAuthorship W2027091569A5045169208 @default.
• W2027091569 hasAuthorship W2027091569A5071022940 @default.
• W2027091569 hasAuthorship W2027091569A5072311778 @default.
• W2027091569 hasAuthorship W2027091569A5075814478 @default.
• W2027091569 hasAuthorship W2027091569A5079331578 @default.
• W2027091569 hasAuthorship W2027091569A5084192875 @default.
• W2027091569 hasAuthorship W2027091569A5088875022 @default.
• W2027091569 hasBestOaLocation W20270915691 @default.
• W2027091569 hasConcept C100773827 @default.
• W2027091569 hasConcept C126322002 @default.

• next