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• W2027095540 abstract "Background: Iron intoxication causes acute nephrotoxicity in animals and humans. Sesame oil, a healthful food, increases resistance to lipid peroxidation and protects against multiple organ injury in various animal models. The authors examined the prophylactic and therapeutic effects of a subcutaneous injection of sesame oil against iron‐induced acute renal injury in mice. Methods: Iron intoxication in mice was induced with an intraperitoneal injection (2 mg/kg) of ferric‐nitrilotriacetate (Fe‐NTA). Various doses of sesame oil (0, 1, 2, and 4 mL/kg, subcutaneously) were given immediately after (prophylactic) or 30 minutes after (therapeutic) the Fe‐NTA injection. Renal injury was assessed by the rise in serum blood urea nitrogen (BUN) and creatinine (CRE) levels 3 hours after the Fe‐NTA injection. Results: One hour after the Fe‐NTA injection, serum BUN and CRE levels were significantly higher in Fe‐NTA‐treated mice than in saline‐treated controls; 3 and 6 hours after the Fe‐NTA injection, they were dose‐dependently and significantly lower in all sesame oil–treated groups than in the group treated only with Fe‐NTA and saline. Conclusion: A subcutaneous injection of sesame oil had both prophylactic and therapeutic effects against iron‐induced acute renal injury in mice." @default.
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• W2027095540 date "2011-10-30" @default.
• W2027095540 modified "2023-10-02" @default.
• W2027095540 title "Prophylactic and Therapeutic Effects of a Subcutaneous Injection of Sesame Oil Against Iron-Induced Acute Renal Injury in Mice" @default.
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• W2027095540 doi "https://doi.org/10.1177/0148607111415530" @default.
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