FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027105684> ?p ?o ?g. }

• W2027105684 endingPage "770" @default.
• W2027105684 startingPage "762" @default.
• W2027105684 abstract "The authors evaluated the neurobehavioral and neuropathologic sequelae after traumatic brain injury (TBI) in transgenic (TG) mice expressing truncated high molecular weight neurofilament (NF) protein fused to beta-galactosidase (NFH-LacZ), which develop Lewy body-like NF-rich inclusions throughout the CNS. TG mice and their wild-type (WT) littermates were subjected to controlled cortical impact brain injury (TG, n=19; WT, n=17) or served as uninjured controls (TG, n =11; WT, n =11). During a 3-week period, mice were evaluated with an array of neuromotor function tests including neuroscore, beam balance, and both fast and slow acceleration rotarod. Brain-injured WT and TG mice showed significant motor dysfunction until 15 days and 21 days post-injury, respectively ( P < .025). Compared with brain-injured WT mice, brain-injured TG mice had significantly greater motor dysfunction as assessed by neuroscore ( P < .01) up to and including 15 days post-injury. Similarly, brain-injured TG mice performed significantly worse than brain-injured WT mice on slow acceleration rotarod at 2, 8, and 15 days post-injury ( P < .05), and beam balance over 2 weeks post-injury ( P < .01). Histopathologic analysis showed significantly greater tissue loss in the injured hemisphere in TG mice at 4 weeks post-injury ( P < .01). Together these data show that NFH-LacZ TG mice are more behaviorally and histologically vulnerable to TBI than WT mice, suggesting that the presence of NF-rich inclusions may exacerbate neuromotor dysfunction and cell death after TBI." @default.
• W2027105684 created "2016-06-24" @default.
• W2027105684 creator A5006990426 @default.
• W2027105684 creator A5010152737 @default.
• W2027105684 creator A5021394368 @default.
• W2027105684 creator A5061860555 @default.
• W2027105684 creator A5073052039 @default.
• W2027105684 creator A5079564982 @default.
• W2027105684 creator A5084326649 @default.
• W2027105684 date "1999-07-01" @default.
• W2027105684 modified "2023-10-11" @default.
• W2027105684 title "Increased Vulnerability of NFH-LacZ Transgenic Mouse to Traumatic Brain Injury-Induced Behavioral Deficits and Cortical Damage" @default.
• W2027105684 cites W1609471181 @default.
• W2027105684 cites W1878737378 @default.
• W2027105684 cites W1960315548 @default.
• W2027105684 cites W1963903234 @default.
• W2027105684 cites W1982184322 @default.
• W2027105684 cites W1983490728 @default.
• W2027105684 cites W1984305500 @default.
• W2027105684 cites W1986234504 @default.
• W2027105684 cites W1993446537 @default.
• W2027105684 cites W1997326980 @default.
• W2027105684 cites W2008712625 @default.
• W2027105684 cites W2010725749 @default.
• W2027105684 cites W2011208889 @default.
• W2027105684 cites W2011575330 @default.
• W2027105684 cites W2011781307 @default.
• W2027105684 cites W2013473672 @default.
• W2027105684 cites W2016870828 @default.
• W2027105684 cites W2018465654 @default.
• W2027105684 cites W2018888883 @default.
• W2027105684 cites W2020380428 @default.
• W2027105684 cites W2026237811 @default.
• W2027105684 cites W2033344414 @default.
• W2027105684 cites W2033365056 @default.
• W2027105684 cites W2039618243 @default.
• W2027105684 cites W2042985028 @default.
• W2027105684 cites W2045776001 @default.
• W2027105684 cites W2051600991 @default.
• W2027105684 cites W2054848243 @default.
• W2027105684 cites W2065042412 @default.
• W2027105684 cites W2067629356 @default.
• W2027105684 cites W2068225967 @default.
• W2027105684 cites W2071434138 @default.
• W2027105684 cites W2083589438 @default.
• W2027105684 cites W2083916407 @default.
• W2027105684 cites W2083952664 @default.
• W2027105684 cites W2093387485 @default.
• W2027105684 cites W2094926613 @default.
• W2027105684 cites W2101818929 @default.
• W2027105684 cites W2116087886 @default.
• W2027105684 cites W2117830068 @default.
• W2027105684 cites W2130866079 @default.
• W2027105684 cites W2148464749 @default.
• W2027105684 cites W2152315537 @default.
• W2027105684 cites W2158799442 @default.
• W2027105684 cites W2165113979 @default.
• W2027105684 cites W2171602378 @default.
• W2027105684 cites W2222580064 @default.
• W2027105684 cites W43432051 @default.
• W2027105684 doi "https://doi.org/10.1097/00004647-199907000-00006" @default.
• W2027105684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10413031" @default.
• W2027105684 hasPublicationYear "1999" @default.
• W2027105684 type Work @default.
• W2027105684 sameAs 2027105684 @default.
• W2027105684 citedByCount "45" @default.
• W2027105684 countsByYear W20271056842012 @default.
• W2027105684 countsByYear W20271056842013 @default.
• W2027105684 countsByYear W20271056842014 @default.
• W2027105684 countsByYear W20271056842015 @default.
• W2027105684 countsByYear W20271056842022 @default.
• W2027105684 crossrefType "journal-article" @default.
• W2027105684 hasAuthorship W2027105684A5006990426 @default.
• W2027105684 hasAuthorship W2027105684A5010152737 @default.
• W2027105684 hasAuthorship W2027105684A5021394368 @default.
• W2027105684 hasAuthorship W2027105684A5061860555 @default.
• W2027105684 hasAuthorship W2027105684A5073052039 @default.
• W2027105684 hasAuthorship W2027105684A5079564982 @default.
• W2027105684 hasAuthorship W2027105684A5084326649 @default.
• W2027105684 hasBestOaLocation W20271056841 @default.
• W2027105684 hasConcept C102230213 @default.
• W2027105684 hasConcept C104317684 @default.
• W2027105684 hasConcept C118552586 @default.
• W2027105684 hasConcept C126322002 @default.
• W2027105684 hasConcept C134018914 @default.
• W2027105684 hasConcept C141035611 @default.
• W2027105684 hasConcept C142724271 @default.
• W2027105684 hasConcept C2777981454 @default.
• W2027105684 hasConcept C2781017439 @default.
• W2027105684 hasConcept C2985495968 @default.
• W2027105684 hasConcept C55493867 @default.
• W2027105684 hasConcept C71924100 @default.
• W2027105684 hasConcept C86803240 @default.
• W2027105684 hasConceptScore W2027105684C102230213 @default.
• W2027105684 hasConceptScore W2027105684C104317684 @default.
• W2027105684 hasConceptScore W2027105684C118552586 @default.
• W2027105684 hasConceptScore W2027105684C126322002 @default.
• W2027105684 hasConceptScore W2027105684C134018914 @default.

• next