FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027111357> ?p ?o ?g. }

• W2027111357 endingPage "1428" @default.
• W2027111357 startingPage "1421" @default.
• W2027111357 abstract "Animal cells disassemble and reassemble their nuclear envelopes (NEs) upon each division [1Burke B. Ellenberg J. Remodelling the walls of the nucleus.Nat. Rev. Mol. Cell Biol. 2002; 3: 487-497Crossref PubMed Scopus (187) Google Scholar, 2Güttinger S. Laurell E. Kutay U. Orchestrating nuclear envelope disassembly and reassembly during mitosis.Nat. Rev. Mol. Cell Biol. 2009; 10: 178-191Crossref PubMed Scopus (342) Google Scholar]. Nuclear envelope breakdown (NEBD) serves as a major regulatory mechanism by which mixing of cytoplasmic and nuclear compartments drives the complete reorganization of cellular architecture, committing the cell for division [2Güttinger S. Laurell E. Kutay U. Orchestrating nuclear envelope disassembly and reassembly during mitosis.Nat. Rev. Mol. Cell Biol. 2009; 10: 178-191Crossref PubMed Scopus (342) Google Scholar, 3Hetzer M.W. The nuclear envelope.Cold Spring Harb. Perspect. Biol. 2010; 2: a000539Crossref Scopus (211) Google Scholar]. Breakdown is initiated by phosphorylation-driven partial disassembly of the nuclear pore complexes (NPCs), increasing their permeability but leaving the overall NE structure intact [4Dultz E. Zanin E. Wurzenberger C. Braun M. Rabut G. Sironi L. Ellenberg J. Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells.J. Cell Biol. 2008; 180: 857-865Crossref PubMed Scopus (189) Google Scholar, 5Laurell E. Beck K. Krupina K. Theerthagiri G. Bodenmiller B. Horvath P. Aebersold R. Antonin W. Kutay U. Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.Cell. 2011; 144: 539-550Abstract Full Text Full Text PDF PubMed Scopus (186) Google Scholar, 6Lénárt P. Rabut G. Daigle N. Hand A.R. Terasaki M. Ellenberg J. Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes.J. Cell Biol. 2003; 160: 1055-1068Crossref PubMed Scopus (120) Google Scholar, 7Terasaki M. Campagnola P. Rolls M.M. Stein P.A. Ellenberg J. Hinkle B. Slepchenko B. A new model for nuclear envelope breakdown.Mol. Biol. Cell. 2001; 12: 503-510Crossref PubMed Scopus (74) Google Scholar]. Subsequently, the NE is rapidly broken into membrane fragments, defining the transition from prophase to prometaphase and resulting in complete mixing of cyto- and nucleoplasm [6Lénárt P. Rabut G. Daigle N. Hand A.R. Terasaki M. Ellenberg J. Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes.J. Cell Biol. 2003; 160: 1055-1068Crossref PubMed Scopus (120) Google Scholar, 8Beaudouin J. Gerlich D. Daigle N. Eils R. Ellenberg J. Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina.Cell. 2002; 108: 83-96Abstract Full Text Full Text PDF PubMed Scopus (354) Google Scholar]. However, the mechanism underlying this rapid NE fragmentation remains largely unknown. Here, we show that NE fragmentation during NEBD in starfish oocytes is driven by an Arp2/3 complex-nucleated F-actin “shell” that transiently polymerizes on the inner surface of the NE. Blocking the formation of this F-actin shell prevents membrane fragmentation and delays entry of large cytoplasmic molecules into the nucleus. We observe spike-like protrusions extending from the F-actin shell that appear to “pierce” the NE during the fragmentation process. Finally, we show that NE fragmentation is essential for successful reproduction, because blocking this process in meiosis leads to formation of aneuploid eggs." @default.
• W2027111357 created "2016-06-24" @default.
• W2027111357 creator A5012753088 @default.
• W2027111357 creator A5029903707 @default.
• W2027111357 creator A5049171298 @default.
• W2027111357 creator A5062419034 @default.
• W2027111357 creator A5074649116 @default.
• W2027111357 creator A5079061958 @default.
• W2027111357 creator A5079519058 @default.
• W2027111357 creator A5081278298 @default.
• W2027111357 creator A5087067085 @default.
• W2027111357 date "2014-06-01" @default.
• W2027111357 modified "2023-09-25" @default.
• W2027111357 title "An Arp2/3 Nucleated F-Actin Shell Fragments Nuclear Membranes at Nuclear Envelope Breakdown in Starfish Oocytes" @default.
• W2027111357 cites W1963929154 @default.
• W2027111357 cites W1968272833 @default.
• W2027111357 cites W2026260372 @default.
• W2027111357 cites W2038011290 @default.
• W2027111357 cites W2042487912 @default.
• W2027111357 cites W2045957964 @default.
• W2027111357 cites W2047724766 @default.
• W2027111357 cites W2052744662 @default.
• W2027111357 cites W2065719801 @default.
• W2027111357 cites W2068701052 @default.
• W2027111357 cites W2075871987 @default.
• W2027111357 cites W2079688311 @default.
• W2027111357 cites W2094115656 @default.
• W2027111357 cites W2098278940 @default.
• W2027111357 cites W2104608706 @default.
• W2027111357 cites W2106675234 @default.
• W2027111357 cites W2121410884 @default.
• W2027111357 doi "https://doi.org/10.1016/j.cub.2014.05.019" @default.
• W2027111357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24909322" @default.
• W2027111357 hasPublicationYear "2014" @default.
• W2027111357 type Work @default.
• W2027111357 sameAs 2027111357 @default.
• W2027111357 citedByCount "56" @default.
• W2027111357 countsByYear W20271113572014 @default.
• W2027111357 countsByYear W20271113572015 @default.
• W2027111357 countsByYear W20271113572016 @default.
• W2027111357 countsByYear W20271113572017 @default.
• W2027111357 countsByYear W20271113572018 @default.
• W2027111357 countsByYear W20271113572019 @default.
• W2027111357 countsByYear W20271113572020 @default.
• W2027111357 countsByYear W20271113572021 @default.
• W2027111357 countsByYear W20271113572022 @default.
• W2027111357 countsByYear W20271113572023 @default.
• W2027111357 crossrefType "journal-article" @default.
• W2027111357 hasAuthorship W2027111357A5012753088 @default.
• W2027111357 hasAuthorship W2027111357A5029903707 @default.
• W2027111357 hasAuthorship W2027111357A5049171298 @default.
• W2027111357 hasAuthorship W2027111357A5062419034 @default.
• W2027111357 hasAuthorship W2027111357A5074649116 @default.
• W2027111357 hasAuthorship W2027111357A5079061958 @default.
• W2027111357 hasAuthorship W2027111357A5079519058 @default.
• W2027111357 hasAuthorship W2027111357A5081278298 @default.
• W2027111357 hasAuthorship W2027111357A5087067085 @default.
• W2027111357 hasBestOaLocation W20271113571 @default.
• W2027111357 hasConcept C104317684 @default.
• W2027111357 hasConcept C126725582 @default.
• W2027111357 hasConcept C1491633281 @default.
• W2027111357 hasConcept C18903297 @default.
• W2027111357 hasConcept C190062978 @default.
• W2027111357 hasConcept C2778175403 @default.
• W2027111357 hasConcept C29512474 @default.
• W2027111357 hasConcept C54355233 @default.
• W2027111357 hasConcept C85813293 @default.
• W2027111357 hasConcept C86339819 @default.
• W2027111357 hasConcept C86803240 @default.
• W2027111357 hasConcept C93304396 @default.
• W2027111357 hasConcept C94912109 @default.
• W2027111357 hasConcept C95444343 @default.
• W2027111357 hasConceptScore W2027111357C104317684 @default.
• W2027111357 hasConceptScore W2027111357C126725582 @default.
• W2027111357 hasConceptScore W2027111357C1491633281 @default.
• W2027111357 hasConceptScore W2027111357C18903297 @default.
• W2027111357 hasConceptScore W2027111357C190062978 @default.
• W2027111357 hasConceptScore W2027111357C2778175403 @default.
• W2027111357 hasConceptScore W2027111357C29512474 @default.
• W2027111357 hasConceptScore W2027111357C54355233 @default.
• W2027111357 hasConceptScore W2027111357C85813293 @default.
• W2027111357 hasConceptScore W2027111357C86339819 @default.
• W2027111357 hasConceptScore W2027111357C86803240 @default.
• W2027111357 hasConceptScore W2027111357C93304396 @default.
• W2027111357 hasConceptScore W2027111357C94912109 @default.
• W2027111357 hasConceptScore W2027111357C95444343 @default.
• W2027111357 hasIssue "12" @default.
• W2027111357 hasLocation W20271113571 @default.
• W2027111357 hasLocation W20271113572 @default.
• W2027111357 hasLocation W20271113573 @default.
• W2027111357 hasLocation W20271113574 @default.
• W2027111357 hasOpenAccess W2027111357 @default.
• W2027111357 hasPrimaryLocation W20271113571 @default.
• W2027111357 hasRelatedWork W2036312848 @default.
• W2027111357 hasRelatedWork W2149328454 @default.
• W2027111357 hasRelatedWork W2168863040 @default.
• W2027111357 hasRelatedWork W2278670241 @default.
• W2027111357 hasRelatedWork W4200019266 @default.

• next