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- W2027136741 abstract "ABSTRACT — Long-term treatment of parkinsonian patients with levodopa (plus decarboxylase inhibitor) leads to decreasing levodopa efficacy and increasing side-effects. Then main therapeutic problems are on-off phenomena, end-of-dose akinesia and levodopa-induced dyskinesias. Deprenyl, a selective MAO-B inhibitor, has produced good therapeutic effects in combination either with levodopa alone or with levodopa plus decarboxylase inhibitor in the treatment of end-of-dose akinesia and on-off phenomena. In an open trial with 48 parkinsonian patients deprenyl was added to previous levodopa plus decarboxylase-inhibitor therapy. Good effects were achieved in respect of mild on-off phenomena and end-of-dose akinesia, minor success in the alleviation of dyskinesia and depression. In four further patients with a post-traumatic parkinsonian syndrome, no improvement of rigidospasticity and vigilance was demonstrable." @default.
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- W2027136741 date "1983-07-01" @default.
- W2027136741 modified "2023-09-23" @default.
- W2027136741 title "Deprenyl (selegiline) in combination treatment of Parkinson's disease" @default.
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- W2027136741 doi "https://doi.org/10.1111/j.1600-0404.1983.tb01526.x" @default.
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