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- W2027137131 abstract "Fcγ receptor (FcγR)-dependent immunoregulation by murine heat-aggregated (HAgg) IgG subclasses on the bacterial lipopolysaccharide (LPS)-induced plaque forming cell (PFC) response to trinotrophenylated sheep red blood cell (TNP-SRBC) antigen and the competitive effect by Fcγ2bR-protein on the down regulation by HAgg-IgG2b were studied in murine T-cell-deprived spleen cell cultures. HAgg-IgG1 and HAgg-IgG3 enhanced the PFC response, but HAgg-IgG2b strongly suppressed the LPS-induced PFC response. HAgg-IgG1 could not compete with the suppressive effect of HAgg-IgG2b. The HAgg-IgG2b seemed to act on both macrophages (Mφ) and B-cells, because the cell cultures that had been reconstituted with HAgg-IgG2b-pretreated Mφ and untreated B-cells and vice versa showed poor PFC responses. The suppression induced by HAgg-IgG2b on the LPS-induced PFC response in the T-cell-deprived cultures was abolished by the addition of phospholipase C (PLC)-treated Fcγ2bR protein at the early stage of the culture. The mechanisms by which HAgg-IgG2b suppress the LPS-induced PFC response and PLC-treated Fcγ2bR protein restores this response were discussed." @default.
- W2027137131 created "2016-06-24" @default.
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- W2027137131 date "1990-01-01" @default.
- W2027137131 modified "2023-09-27" @default.
- W2027137131 title "IgG2b-dependent down regulation of the LPS-induced PFC-response and its blockade by Fcγ2bR protein" @default.
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- W2027137131 doi "https://doi.org/10.1016/0192-0561(90)90083-y" @default.
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