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- W2027140152 abstract "Bone-marrow samples were collected from 48 CAEV-seropositive, symptomless goats (30 kids, 18 adults). The samples were formalin-fixed and processed for histological examination. In addition, all samples were examined immunohistochemically with a monoclonal antibody (1A7) against the p27 capsid protein of maedi-visna virus, an antibody which cross-reacts with the Ca-p27 of CAEV. Samples from 16 goats (10/30 kids, 6/18 adults) showed positive immunolabelling of bone-marrow stromal cells (fibrocytes, endothelial cells and adipocytes) and of scattered macrophages, whereas haematopoietic cells were negative. The detection of viral Ca-p27 protein in bone-marrow fibrocytes was consistent with previous in-vitro studies which indicated that such cells are semi-permissive for CAEV infection. It is speculated that bone-marrow stromal cells represent a viral reservoir in symptomless animals." @default.
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- W2027140152 date "2005-08-01" @default.
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- W2027140152 title "Immunohistochemical Detection of the p27 Capsid Protein of Caprine Arthritis–Encephalitis Virus (CAEV) in Bone-marrow Cells of Seropositive Goats" @default.
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- W2027140152 doi "https://doi.org/10.1016/j.jcpa.2005.01.009" @default.
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