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- W2027141959 abstract "To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk.Case-control study, comparing 203 children with spina bifida to 583 controls.Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alone was associated with an odds ratio for spina bifida of 1.57 (95% confidence interval [CI], 1.02-2.38). For the 844ins68 allele of cystathionine-beta-synthase alone, the odds ratio was 0.83 (95% CI, 0.39-1.64). For the joint genotype, the odds ratio was 3.69 (95% CI, 1.04-13.50).Interactions between common alleles of folate genes might contribute to the risk for spina bifida." @default.
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- W2027141959 date "2002-05-01" @default.
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- W2027141959 title "Spina bifida and folate-related genes: A study of gene-gene interactions" @default.
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- W2027141959 doi "https://doi.org/10.1097/00125817-200205000-00005" @default.
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