Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027145792> ?p ?o ?g. }
- W2027145792 endingPage "337" @default.
- W2027145792 startingPage "332" @default.
- W2027145792 abstract "Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with in vivo microdialysis before and after a challenge with systemic D-amphetamine (1.0 mg/kg, i.p.). Prior to challenge, basal extracellular concentrations of DA in the N.Acc. did not differ in VTA amphetamine- and saline-preexposed animals. Following challenge, however, both groups showed an increase in N.Acc. DA but this was significantly greater (2-fold) in VTA amphetamine-preexposed animals. These latter animals also showed significantly higher DA metabolite levels in comparison to saline-preexposed animals prior to (DOPAC) as well as after challenge (HVA). These findings extend those of behavioral experiments showing that intra-VTA amphetamine produces sensitized locomotor responding to drug challenge (J. Pharmacol. Exp. Ther., 245 (1988) 1095-1102; Brain Res., 516 (1990) 99-106; Ann. NY Acad. Sci., 654 (1992) 444-447) and demonstrate that amphetamine applied to the somatodendritic region of mesolimbic DA neurons sensitizes these neurons as evidenced by their enhanced N.Acc. DA response to a systemic amphetamine challenge." @default.
- W2027145792 created "2016-06-24" @default.
- W2027145792 creator A5045976914 @default.
- W2027145792 date "1993-03-01" @default.
- W2027145792 modified "2023-10-16" @default.
- W2027145792 title "Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat" @default.
- W2027145792 cites W1576599655 @default.
- W2027145792 cites W1977353048 @default.
- W2027145792 cites W1980695662 @default.
- W2027145792 cites W1980839482 @default.
- W2027145792 cites W1982383406 @default.
- W2027145792 cites W1983302605 @default.
- W2027145792 cites W1985113861 @default.
- W2027145792 cites W1985484876 @default.
- W2027145792 cites W1986671246 @default.
- W2027145792 cites W1998420008 @default.
- W2027145792 cites W2000667455 @default.
- W2027145792 cites W2003446256 @default.
- W2027145792 cites W2008780733 @default.
- W2027145792 cites W2009243814 @default.
- W2027145792 cites W2012113795 @default.
- W2027145792 cites W2017659194 @default.
- W2027145792 cites W2030708327 @default.
- W2027145792 cites W2035611467 @default.
- W2027145792 cites W2037506390 @default.
- W2027145792 cites W2066105521 @default.
- W2027145792 cites W2075060283 @default.
- W2027145792 cites W2077324024 @default.
- W2027145792 cites W2080774795 @default.
- W2027145792 cites W2081979454 @default.
- W2027145792 cites W2082072754 @default.
- W2027145792 cites W2084954062 @default.
- W2027145792 cites W2085665176 @default.
- W2027145792 cites W2087020488 @default.
- W2027145792 cites W2089123987 @default.
- W2027145792 cites W2093006029 @default.
- W2027145792 cites W2101034745 @default.
- W2027145792 cites W4319293053 @default.
- W2027145792 doi "https://doi.org/10.1016/0006-8993(93)91761-g" @default.
- W2027145792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8386970" @default.
- W2027145792 hasPublicationYear "1993" @default.
- W2027145792 type Work @default.
- W2027145792 sameAs 2027145792 @default.
- W2027145792 citedByCount "157" @default.
- W2027145792 countsByYear W20271457922012 @default.
- W2027145792 countsByYear W20271457922013 @default.
- W2027145792 countsByYear W20271457922015 @default.
- W2027145792 countsByYear W20271457922016 @default.
- W2027145792 countsByYear W20271457922017 @default.
- W2027145792 countsByYear W20271457922018 @default.
- W2027145792 countsByYear W20271457922019 @default.
- W2027145792 countsByYear W20271457922020 @default.
- W2027145792 countsByYear W20271457922021 @default.
- W2027145792 crossrefType "journal-article" @default.
- W2027145792 hasAuthorship W2027145792A5045976914 @default.
- W2027145792 hasConcept C126322002 @default.
- W2027145792 hasConcept C134018914 @default.
- W2027145792 hasConcept C137183658 @default.
- W2027145792 hasConcept C170493617 @default.
- W2027145792 hasConcept C185592680 @default.
- W2027145792 hasConcept C2775841634 @default.
- W2027145792 hasConcept C2775864247 @default.
- W2027145792 hasConcept C2775905480 @default.
- W2027145792 hasConcept C2776552330 @default.
- W2027145792 hasConcept C2777193897 @default.
- W2027145792 hasConcept C2777397205 @default.
- W2027145792 hasConcept C2780948874 @default.
- W2027145792 hasConcept C50156730 @default.
- W2027145792 hasConcept C513476851 @default.
- W2027145792 hasConcept C55493867 @default.
- W2027145792 hasConcept C71924100 @default.
- W2027145792 hasConcept C98274493 @default.
- W2027145792 hasConceptScore W2027145792C126322002 @default.
- W2027145792 hasConceptScore W2027145792C134018914 @default.
- W2027145792 hasConceptScore W2027145792C137183658 @default.
- W2027145792 hasConceptScore W2027145792C170493617 @default.
- W2027145792 hasConceptScore W2027145792C185592680 @default.
- W2027145792 hasConceptScore W2027145792C2775841634 @default.
- W2027145792 hasConceptScore W2027145792C2775864247 @default.
- W2027145792 hasConceptScore W2027145792C2775905480 @default.
- W2027145792 hasConceptScore W2027145792C2776552330 @default.
- W2027145792 hasConceptScore W2027145792C2777193897 @default.
- W2027145792 hasConceptScore W2027145792C2777397205 @default.
- W2027145792 hasConceptScore W2027145792C2780948874 @default.
- W2027145792 hasConceptScore W2027145792C50156730 @default.
- W2027145792 hasConceptScore W2027145792C513476851 @default.
- W2027145792 hasConceptScore W2027145792C55493867 @default.
- W2027145792 hasConceptScore W2027145792C71924100 @default.
- W2027145792 hasConceptScore W2027145792C98274493 @default.
- W2027145792 hasIssue "2" @default.
- W2027145792 hasLocation W20271457921 @default.
- W2027145792 hasLocation W20271457922 @default.
- W2027145792 hasOpenAccess W2027145792 @default.
- W2027145792 hasPrimaryLocation W20271457921 @default.
- W2027145792 hasRelatedWork W1974817806 @default.
- W2027145792 hasRelatedWork W1975723323 @default.
- W2027145792 hasRelatedWork W1976047443 @default.
- W2027145792 hasRelatedWork W2001174391 @default.