FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027172013> ?p ?o ?g. }

• W2027172013 endingPage "764" @default.
• W2027172013 startingPage "756" @default.
• W2027172013 abstract "FAM20C is a secretory kinase responsible for the phosphorylation of multiple secreted proteins in mammalian cells; it has been shown to phosphorylate serine residues within a variety of different bone proteins. In this work we demonstrate that FAM20C also phosphorylates threonines, specifically those within the N-terminal domain of the neuroendocrine chaperone 7B2. Analysis of the primary sequence of 7B2 revealed that three threonine residues in its N-terminal domain are located within FAM20C consensus motifs: Thr73, Thr99, and Thr111. The individual substitution of Thr73 and Thr111 residues by neutral alanines caused a marked decrease in the total phosphorylation of 7B2. Furthermore, the phosphomimetic substitution of Thr111 by Glu clearly diminished the ability of 7B2 to activate pro-prohormone convertase 2 (PC2) in 7B2-lacking SK-N-MC neuroblastoma cells, suggesting that the phosphorylation of this residue critically impacts the 7B2-proPC2 interaction. However, the phosphomimetic mutation did not alter 7B2's ability to function as an antiaggregant for human islet amyloid polypeptide. FAM20C-mediated phosphorylation of a common alternatively spliced variant of human 7B2 that lacks Ala100 (thus eliminating the Thr99 phosphorylation consensus site) was similar to the Ala-containing protein, but this variant did not activate proPC2 as efficiently as the Ala-containing protein. Although threonines within 7B2 were phosphorylated efficiently, FAM20C was incapable of performing the well-known regulatory threonine phosphorylation of the molecular chaperone binding immunoglobulin protein. Taken together, these results indicate that FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing." @default.
• W2027172013 created "2016-06-24" @default.
• W2027172013 creator A5034099378 @default.
• W2027172013 creator A5053750979 @default.
• W2027172013 date "2015-05-01" @default.
• W2027172013 modified "2023-10-16" @default.
• W2027172013 title "Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation" @default.
• W2027172013 cites W1500851053 @default.
• W2027172013 cites W1503639662 @default.
• W2027172013 cites W1512050447 @default.
• W2027172013 cites W1517461798 @default.
• W2027172013 cites W1546139069 @default.
• W2027172013 cites W1550508087 @default.
• W2027172013 cites W1606943476 @default.
• W2027172013 cites W17493816 @default.
• W2027172013 cites W1966603503 @default.
• W2027172013 cites W1972711677 @default.
• W2027172013 cites W1980312793 @default.
• W2027172013 cites W1980785678 @default.
• W2027172013 cites W1981780687 @default.
• W2027172013 cites W1983579422 @default.
• W2027172013 cites W1988119351 @default.
• W2027172013 cites W1989738914 @default.
• W2027172013 cites W1993718695 @default.
• W2027172013 cites W1996160739 @default.
• W2027172013 cites W2004354005 @default.
• W2027172013 cites W2008150799 @default.
• W2027172013 cites W2011714902 @default.
• W2027172013 cites W2020447501 @default.
• W2027172013 cites W2025399103 @default.
• W2027172013 cites W2027903664 @default.
• W2027172013 cites W2033785962 @default.
• W2027172013 cites W2040328099 @default.
• W2027172013 cites W2043051186 @default.
• W2027172013 cites W2047652128 @default.
• W2027172013 cites W2052035252 @default.
• W2027172013 cites W2058116732 @default.
• W2027172013 cites W2062578000 @default.
• W2027172013 cites W2063587524 @default.
• W2027172013 cites W2067941297 @default.
• W2027172013 cites W2072410706 @default.
• W2027172013 cites W2085733779 @default.
• W2027172013 cites W2085997090 @default.
• W2027172013 cites W2086053237 @default.
• W2027172013 cites W2095535542 @default.
• W2027172013 cites W2102392672 @default.
• W2027172013 cites W2115070143 @default.
• W2027172013 cites W2129105465 @default.
• W2027172013 cites W2144040584 @default.
• W2027172013 cites W2156135176 @default.
• W2027172013 cites W2157658519 @default.
• W2027172013 cites W2158561816 @default.
• W2027172013 cites W2165725943 @default.
• W2027172013 cites W2168386087 @default.
• W2027172013 cites W2169477593 @default.
• W2027172013 cites W2192080449 @default.
• W2027172013 cites W4240896746 @default.
• W2027172013 doi "https://doi.org/10.1210/me.2014-1394" @default.
• W2027172013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4415208" @default.
• W2027172013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25811241" @default.
• W2027172013 hasPublicationYear "2015" @default.
• W2027172013 type Work @default.
• W2027172013 sameAs 2027172013 @default.
• W2027172013 citedByCount "8" @default.
• W2027172013 countsByYear W20271720132015 @default.
• W2027172013 countsByYear W20271720132016 @default.
• W2027172013 countsByYear W20271720132018 @default.
• W2027172013 countsByYear W20271720132019 @default.
• W2027172013 countsByYear W20271720132021 @default.
• W2027172013 crossrefType "journal-article" @default.
• W2027172013 hasAuthorship W2027172013A5034099378 @default.
• W2027172013 hasAuthorship W2027172013A5053750979 @default.
• W2027172013 hasBestOaLocation W20271720131 @default.
• W2027172013 hasConcept C104551158 @default.
• W2027172013 hasConcept C11960822 @default.
• W2027172013 hasConcept C142724271 @default.
• W2027172013 hasConcept C184235292 @default.
• W2027172013 hasConcept C2775880066 @default.
• W2027172013 hasConcept C2775962898 @default.
• W2027172013 hasConcept C2776414213 @default.
• W2027172013 hasConcept C2780090379 @default.
• W2027172013 hasConcept C2910756308 @default.
• W2027172013 hasConcept C55493867 @default.
• W2027172013 hasConcept C71315377 @default.
• W2027172013 hasConcept C71924100 @default.
• W2027172013 hasConcept C86803240 @default.
• W2027172013 hasConcept C87325107 @default.
• W2027172013 hasConcept C95444343 @default.
• W2027172013 hasConcept C97029542 @default.
• W2027172013 hasConceptScore W2027172013C104551158 @default.
• W2027172013 hasConceptScore W2027172013C11960822 @default.
• W2027172013 hasConceptScore W2027172013C142724271 @default.
• W2027172013 hasConceptScore W2027172013C184235292 @default.
• W2027172013 hasConceptScore W2027172013C2775880066 @default.
• W2027172013 hasConceptScore W2027172013C2775962898 @default.
• W2027172013 hasConceptScore W2027172013C2776414213 @default.
• W2027172013 hasConceptScore W2027172013C2780090379 @default.
• W2027172013 hasConceptScore W2027172013C2910756308 @default.

• next